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  • Conference paper
    Cookson WO, 1995,

    11q and high-affinity IgE receptor in asthma and allergy.

    , Pages: 71-73, ISSN: 0954-7894
  • Journal article
    Hill MR, James AL, Faux JA, Ryan G, Hopkin JM, le Söuef P, Musk AW, Cookson WOet al., 1995,

    Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample.

    , BMJ, Vol: 311, Pages: 776-779, ISSN: 0959-8138

    OBJECTIVE: To establish the prevalence of Fc epsilon RI-beta polymorphisms Leu181 and Leu181/Leu183 on chromosome 11q13 in the general population and to examine whether when maternally inherited they confer a risk of atopy. DESIGN: A population based survey for measures of atopy (skin prick test reactions, specific IgE titres, total serum IgE concentration), bronchial hyperresponsiveness, and carriage of Fc epsilon RI-beta Leu181 and Leu181/Leu183. SETTING: The rural coastal town of Busselton, Western Australia. SUBJECTS: 1004 members of 230 two generation families identified through adults aged under 55. RESULTS: Fc epsilon RI-beta Leu181/Leu183 was identified in 45 subjects (4.5%). All 13 children who had inherited the variant maternally were atopic. Six had asthma and nine rhinitis. The odds ratio of a positive skin prick test reaction to house dust mite or grass pollen in these children compared with the other 523 children was 7.37 (95% confidence interval 1.62 to 33.60). The 95% confidence interval for the odds ratio of a positive specific IgE response (radio-allergosorbent test) was 3.00 to infinity, and the odds ratio for bronchial hyperresponsiveness was 3.70 (1.21 to 11.60). By contrast, the eight children who had derived the variant paternally had negative skin prick and radioallergosorbent test results and did not have increased bronchial responsiveness. CONCLUSION: Fc epsilon RI"' beta Leu181/Leu183 when inherited maternally identifies a genetic risk factor for atopy and bronchial hyperresponsiveness.
  • Journal article
    LANGDON T, SHEERINS A, RAVAGNANI A, GIELKENS M, CADDICK MX, ARST HNet al., 1995,

    MUTATIONAL ANALYSIS REVEALS DISPENSABILITY OF THE N-TERMINAL REGION OF THE ASPERGILLUS TRANSCRIPTION FACTOR MEDIATING NITROGEN METABOLITE REPRESSION

    , MOLECULAR MICROBIOLOGY, Vol: 17, Pages: 877-888, ISSN: 0950-382X
  • Journal article
    RAVAGNANI A, ARST HN, 1995,

    QUANTITATION OF OLIGOHISTIDINE FUSION PROTEINS USING NI-63(2+) CHELATION

    , NUCLEIC ACIDS RESEARCH, Vol: 23, Pages: 3069-3070, ISSN: 0305-1048
  • Journal article
    OREJAS M, ESPESO EA, TILBURN J, SARKAR S, ARST HN, PENALVA MAet al., 1995,

    ACTIVATION OF THE ASPERGILLUS PACC TRANSCRIPTION FACTOR IN RESPONSE TO ALKALINE AMBIENT PH REQUIRES PROTEOLYSIS OF THE CARBOXY-TERMINAL MOIETY

    , GENES & DEVELOPMENT, Vol: 9, Pages: 1622-1632, ISSN: 0890-9369
  • Journal article
    DIALLINAS G, GORFINKIEL L, ARST HN, CECCHETTO G, SCAZZOCCHIO Cet al., 1995,

    GENETIC AND MOLECULAR CHARACTERIZATION OF A GENE ENCODING A WIDE SPECIFICITY PURINE PERMEASE OF ASPERGILLUS-NIDULANS REVEALS A NOVEL FAMILY OF TRANSPORTERS CONSERVED IN PROKARYOTES AND EUKARYOTES

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 270, Pages: 8610-8622, ISSN: 0021-9258
  • Journal article
    Clutterbuck AJ, Arst H, 1995,

    Genetic nomenclature guide. Aspergillus nidulans.

    , Trends Genet, Pages: 13-14, ISSN: 0168-9525
  • Journal article
    TILBURN J, SARKAR S, WIDDICK DA, ESPESO EA, OREJAS M, MUNGROO J, PENALVA MA, ARST HNet al., 1995,

    THE ASPERGILLUS PACC ZINC-FINGER TRANSCRIPTION FACTOR MEDIATES REGULATION OF BOTH ACID-EXPRESSED AND ALKALINE-EXPRESSED GENES BY AMBIENT PH

    , EMBO JOURNAL, Vol: 14, Pages: 779-790, ISSN: 0261-4189
  • Journal article
    Hill MR, Cookson WO, 1995,

    Reply to “Atopy in Australia”

    , Nature Genetics, Vol: 10, ISSN: 1061-4036
  • Journal article
    Young RP, Barker RD, Pile KD, Cookson WO, Taylor AJet al., 1995,

    The association of HLA-DR3 with specific IgE to inhaled acid anhydrides.

    , Am J Respir Crit Care Med, Vol: 151, Pages: 219-221, ISSN: 1073-449X

    We have undertaken a case referent study of the association between HLA allele frequency and specific IgE antibody to acid anhydride-human serum albumin (AA-HSA) conjugates among acid anhydride workers. Thirty cases with radio-allergosorbent test score versus AA-HSA conjugates > 2 were compared with 30 referents without specific IgE selected from the same factory sites as the cases and matched for age, sex, duration of exposure, atopic status, and smoking habit. We found a significant excess of HLA-DR3 in the cases with specific IgE to acid anhydrides when compared with the referents (50% versus 14%, Fisher's statistic = 8.4; odds ratio = 6, p = 0.05 corrected). The excess of HLA-DR3 was particularly associated with IgE versus trimellitic anhydride, with HLA-DR3 present in eight of 11 workers with and in two of 14 referents without IgE (Fisher's statistic = 8.5, odds ratio = 16, p = 0.004). The proportion of HLA-DR3 among the phthalic anhydride workers was not different in those with IgE (two of 12) from their referents (two of 14). These findings suggest MHC II proteins are an important determinant of the specificity of the IgE response to an inhaled hapten.

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