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• Journal article
  Stern M, Phillips J, Jaffe A, Farley R, Chadwick S, Davies J, Smith S, Browning J, Hodson ME, Durham S, Li D, Jeffery P, Scallah M, Balfour R, Cheng S, Smith A, Meeker D, Geddes DM, Alton EWFWet al., 1997,

  A double blind placebo controlled trial of pulmonary and nasal administration of liposome-mediated CFTR gene transfer in CF subjects

  , Thorax, Vol: 52, ISSN: 0040-6376

  We and others have previously shown functional changes folllowing liposome-mediated CFTR gene transfer to the nasal epithelium of CF subjects. We have now studied the safety and efficacy of this approach in the lungs and nose of CF subjects in a double blind placebo controlled study. 8 Subjects were randomised to receive DNA liposome complex or lipid alone by nebulisation into the lungs with 8 further subjects receiving the liposome alone. One week later, the same subjects received the same treatment by nasal administration. Safety was assessed clinically, radiographically, by pulmonary function and histological analysis. Efficacy was assessed by analysis of CFTR DNA, mRNA, in vivo potential difference, SPQ fluorescence, bacterial adherence and mucociliary clearance (nose only). The majority of subjects receiving the active complex noted mild flu-like symptoms which resolved within 36 hours. A proportion of both active and placebo subjects noted mild respiratory symptoms over a period of 12 hours following pulmonary administration. No specific treatment was required for either event. Pulmonary administration resulted in a significant (p<0.05) degree of correction of the chloride abnormality in the active, but not placebo treated subjects. No alterations in the sodium transport were detected. A similar pattern was observed following nasal administration. This study provides proof-of-principle that cationic liposome mediated CFTR gene transfer is able to influence significantly the underlying electrophysiological defect in the lungs of cystic fibrosis patients.

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  • Citations: 4
• Journal article
  Desai SR, Sidhu PS, Dawson JM, 1997,

  An unusual consequence of stereotactic colloid cyst aspiration: case report.

  , Australas Radiol, Vol: 41, Pages: 377-379, ISSN: 0004-8461

  The removal of a colloid cyst of the third ventricle by stereotactic cyst aspiration is frequently performed as an alternative to a transcortical-transventricular or transcallosal operative route. A consequence of a CT-guided stereotactic aspiration, where residual colloid cyst material has been dislodged into the lateral ventricle and likened to an intraventricular mouse, is described.

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• Journal article
  Moffatt MF, Cookson WO, 1997,

  Linkage and candidate gene studies in asthma.

  , Am J Respir Crit Care Med, Vol: 156, Pages: S110-S112, ISSN: 1073-449X
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• Journal article
  Davies J, Bush A, 1997,

  Infection in patients with cystic fibrosis and congenital immune deficiencies

  , CURRENT OPINION IN INFECTIOUS DISEASES, Vol: 10, Pages: 268-274, ISSN: 0951-7375
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  • Citations: 1
• Journal article
  Arst HN, Holden DW, Caddick MX, 1997,

  Evolution of transcription-regulating proteins: caveat lector!

  , GENE, Vol: 173, Pages: S1-S4, ISSN: 0378-1119
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  • Citations: 1
• Journal article
  Spanu P, 1997,

  HCF-1, a hydrophobin from the tomato pathogen Cladosporium fulvum

  , GENE, Vol: 193, Pages: 89-96, ISSN: 0378-1119
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  • Citations: 23
• Journal article
  Ravagnani A, Gorfinkiel L, Langdon T, Diallinas G, Adjadj E, Demais S, Gorton D, Arst HN, Scazzocchio Cet al., 1997,

  Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA

  , EMBO JOURNAL, Vol: 16, Pages: 3974-3986, ISSN: 0261-4189
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  • Citations: 137
• Journal article
  Palmer LJ, Paré PD, Faux JA, Moffatt MF, Daniels SE, LeSouëf PN, Bremner PR, Mockford E, Gracey M, Spargo R, Musk AW, Cookson WOet al., 1997,

  Fc epsilon R1-beta polymorphism and total serum IgE levels in endemically parasitized Australian aborigines.

  , Am J Hum Genet, Vol: 61, Pages: 182-188, ISSN: 0002-9297

  Endemic helminthic infection is a major public-health problem and affects a large proportion of the world's population. In Australia, helminthic infection is endemic in Aboriginal communities living in tropical northern regions of the continent. Such infection is associated with nonspecific (polyclonal) stimulation of IgE synthesis and highly elevated total serum IgE levels. There is evidence that worm-infection variance (i.e., human capacity of resistance) and total serum IgE levels may be related to the presence of a major codominant gene. The beta chain of the high-affinity IgE receptor, Fc epsilon R1-beta, has been previously identified as a candidate for the close genetic linkage of the 11q13 region to IgE responses in several populations. We show a biallelic RsaI polymorphism in Fc epsilon R1-beta to be associated with total serum IgE levels (P = .0001) in a tropical population of endemically parasitized Australian Aborigines (n = 234 subjects). The polymorphism explained 12.4% of the total residual variation in serum total IgE and showed a significant (P = .0000) additive relationship with total serum IgE levels, across the three genotypes. These associations were independent of familial correlations, age, gender, racial admixture, or smoking status. Alleles of a microsatellite repeat in intron 5 of the same gene showed similar associations. The results suggest that variation in Fc epsilon R1-beta may regulate IgE-mediated immune responses in this population.

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• Journal article
  Desai SR, Nicholson AG, Stewart S, Twentyman OM, Flower CDR, Hansell DMet al., 1997,

  Benign pulmonary lymphocytic infiltration and amyloidosis: Computed tomographic and pathologic features in three cases

  , JOURNAL OF THORACIC IMAGING, Vol: 12, Pages: 215-220, ISSN: 0883-5993
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  • Citations: 64
• Journal article
  Davidson SJ, Burman JF, Davies J, Bush Aet al., 1997,

  Cystic fibrosis and factor XII deficiency

  , THROMBOSIS AND HAEMOSTASIS, Pages: PS869-PS869, ISSN: 0340-6245
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