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• Journal article
  Mitchell TJ, Walley AJ, Pease JE, Venables PJW, Wiltshire S, Williams TJ, Cookson WOCMet al., 2000,

  Delta 32 deletion of CCR5 gene and association with asthma or atopy

  , LANCET, Vol: 356, Pages: 1491-1492, ISSN: 0140-6736
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  • Citations: 40
• Journal article
  Donnadieu E, Cookson WO, Jouvin MH, Kinet JPet al., 2000,

  Allergy-associated polymorphisms of the Fc epsilon RI beta subunit do not impact its two amplification functions.

  , J Immunol, Vol: 165, Pages: 3917-3922, ISSN: 0022-1767

  Two variants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have been found associated with allergy. We have previously shown that the beta-chain plays at least two distinct amplifier functions. It amplifies Fc epsilon RI surface expression and signaling, resulting in an estimated 12- to 30-fold amplification of downstream events. To test the hypothesis that the I181L-V183L and E237G beta variants may be functionally relevant and could directly contribute to an allergic phenotype, we have evaluated the functional impact of the beta variants on the two amplifier functions of beta. We found that these variants have no direct effect on the beta amplifier functions. However, the possibility remains that these variants are in linkage disequilibrium with other more relevant polymorphisms or are affecting unknown beta-chain functions.

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• Journal article
  Taylor JW, Jacobson DJ, Kroken S, Kasuga T, Geiser DM, Hibbett DS, Fisher MCet al., 2000,

  Phylogenetic species recognition and species concepts in fungi

  , FUNGAL GENETICS AND BIOLOGY, Vol: 31, Pages: 21-32, ISSN: 1087-1845
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  • Citations: 1511
• Journal article
  Cookson WO, Moffatt MF, 2000,

  Genetics of asthma and allergic disease.

  , Hum Mol Genet, Vol: 9, Pages: 2359-2364, ISSN: 0964-6906

  Atopic (allergic) asthma is the most common disease of childhood and is strongly genetic in origin. Many genome-wide screens for asthma and its associated traits have now been carried out, and genetic linkage has been consistently identified in several regions. It is probable that these loci contain major genes influencing atopy and asthma. Candidate genes have already been identified from the cytokine cluster on chromosome 5 and the MHC on chromosome 6. These complex regions contain more than one susceptibility locus for allergic disease. Other regions do not contain obvious candidate genes, and positional cloning of these loci is likely to identify novel disease pathways. Parent-of-origin effects are prominent at some of the loci and some also show linkage to other inflammatory immune diseases. Several single gene disorders are associated with allergic disease and on occasion are also linked to the same chromosomal regions. The positional cloning of asthma genes is now feasible.

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• Journal article
  Lonjou C, Barnes K, Chen H, Cookson WOCM, Deichmann KA, Hall IP, Holloway JW, Laitinen T, Palmer LJ, Wjst M, Morton NEet al., 2000,

  A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG)

  , Proceedings of the National Academy of Sciences of the United States of America, Vol: 97, Pages: 10942-10947, ISSN: 0027-8424

  The central problem of complex inheritance is to map oligogenes for disease susceptibility, integrating linkage and association over samples that differ in several ways. Combination of evidence over multiple samples with 1,037 families supports loci contributing to asthma susceptibility in the cytokine region on 5q [maximum logarithm of odds (lod) = 2.61 near IL-4], but no evidence for atopy. The principal problems with retrospective collaboration on linkage appear to have been solved, providing far more information than a single study. A multipoint lod table evaluated at commonly agreed reference loci is required for both collaboration and metaanalysis, but variations in ascertainment, pedigree structure, phenotype definition, and marker selection are tolerated. These methods are invariant with statistical methods that increase the power of lods and are applicable to all diseases, motivating collaboration rather than competition. In contrast to linkage, positional cloning by allelic association has yet to be extended to multiple samples, a prerequisite for efficient combination with linkage and the greatest current challenge to genetic epidemiology.

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  • Citations: 39
• Journal article
  Cota E, Hamill SJ, Fowler SB, Clarke Jet al., 2000,

  Two proteins with the same structure respond very differently to mutation: The role of plasticity in protein stability

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 302, Pages: 713-725, ISSN: 0022-2836
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  • Citations: 66
• Journal article
  Palmer LJ, Cookson WO, 2000,

  Genomic approaches to understanding asthma.

  , Genome Res, Vol: 10, Pages: 1280-1287, ISSN: 1088-9051

  Asthma is the most common chronic childhood disease in developed nations, and it is a complex disease that has high social and economic costs. Asthma and its associated intermediate phenotypes are under a substantial degree of genetic control. The genetic aetiology of asthma offers a means of better understanding its pathogenesis and, thus, improving preventive strategies, diagnostic tools, and therapies. Considerable effort and expense have been expended in attempts to detect genetic loci contributing to asthma susceptibility, and extensive candidate gene studies and a number of whole-genome screens have been undertaken. This article reviews the current state of knowledge of the genetics of asthma, with a focus on genomic approaches to understanding allergic diseases.

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• Journal article
  Ito K, Barnes PJ, Adcock IM, 2000,

  Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1β-induced histone H4 acetylation on lysines 8 and 12

  , MOLECULAR AND CELLULAR BIOLOGY, Vol: 20, Pages: 6891-6903, ISSN: 0270-7306
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  • Citations: 563
• Journal article
  Byrne B, Abramson J, Jansson M, Holmgren E, Iwata Set al., 2000,

  Fusion protein approach to improve the crystal quality of cytochrome <i>bo</i>₃ ubiquinol oxidase from <i>Escherichia coli</i>

  , BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Vol: 1459, Pages: 449-455, ISSN: 0005-2728
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  • Citations: 9
• Journal article
  Fisher MC, Koenig G, White TJ, Taylor JWet al., 2000,

  A test for concordance between the multilocus genealogies of genes and microsatellites in the pathogenic fungus <i>Coccidioides immitis</i>

  , MOLECULAR BIOLOGY AND EVOLUTION, Vol: 17, Pages: 1164-1174, ISSN: 0737-4038
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  • Citations: 75

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