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• Journal article
  Hill MR, Cookson WO, 1996,

  A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness.

  , Hum Mol Genet, Vol: 5, Pages: 959-962, ISSN: 0964-6906

  The high affinity receptor for IgE (Fc epsilon RI) has a central role in mast cell degranulation and IgE mediated allergy. A systematic search through the coding regions of the beta subunit of Fc epsilon RI (Fc epsilon RI-beta) has identified a novel coding polymorphism in exon seven. An adenine to guanine substitution changes amino acid residue 237 from glutamic acid to glycine (E237G), in the cytoplasmic tail of the protein. E237G is predicted to introduce a hydrophobicity change within the C-terminus of Fc epsilon RI-beta. It is adjacent to the immunoreceptor tyrosine activation motif (ITAM), and may affect the intracellular signalling capacity of Fc epsilon RI. E237G was detected in 53 subjects from an Australian general population sample of 1004 individuals (5.3%). E237G positive subjects had a significantly elevated skin test response to grass (p = 0.0004) and house dust mite (p = 0.04), RAST to grass (p = 0.002) and bronchial reactivity to methacholine (p = 0.0009). The relative risk of individuals with E237G having asthma compared to subjects without the variant was 2.3 (95% CI 1.26-4.19; p = 0.005).

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• Journal article
  Arst HN, Sheerins A, 1996,

  Erratum: Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (Molecular Microbiology (1996) 19 (5), 1019-1024)

  , Molecular Microbiology, Vol: 20, ISSN: 0950-382X
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• Journal article
  Moffatt M, Cookson W, 1996,

  Naked DNA: new shots for allergy?

  , Nat Med, Vol: 2, Pages: 515-516, ISSN: 1078-8956
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• Journal article
  Arst HN, Sheerins A, 1996,

  Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans (vol 19, pg 1019, 1996)

  , MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 901-901, ISSN: 0950-382X
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• Journal article
  Sarkar S, Caddick MX, Bignell E, Tilburn J, Arst HNet al., 1996,

  Regulation of gene expression by ambient pH in Aspergillus: Genes expressed at acid pH

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 24, Pages: 360-363, ISSN: 0300-5127
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  • Citations: 32
• Journal article
  Langdon T, Sheerins A, Ravagnani A, Gielkens M, Caddick MX, Arst HNet al., 1996,

  Erratum: Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (Mol Microbiol. (1995), 17 (5), 877-888)

  , Molecular Microbiology, Vol: 20, ISSN: 0950-382X
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• Journal article
  Langdon T, Sheerins A, Ravagnani A, Gielkens M, Caddick MX, Arst HNet al., 1996,

  Mutational analysis reveals dispensability of the N-terminal region of the Aspergillus transcription factor mediating nitrogen metabolite repression (vol 17, pg 877, 1995)

  , MOLECULAR MICROBIOLOGY, Vol: 20, Pages: 239-239, ISSN: 0950-382X
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  • Citations: 1
• Journal article
  Arst HN, Sheerins A, 1996,

  Translational initiation competence, 'leaky scanning' and translational reinitiation in areA mRNA of Aspergillus nidulans

  , MOLECULAR MICROBIOLOGY, Vol: 19, Pages: 1019-1024, ISSN: 0950-382X
  • Author Web Link
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  • Citations: 23
• Journal article
  Davies J, Rosenthal M, Bush A, 1996,

  Severe small airways disease resistant to medical treatment in a child with cystic fibrosis

  , JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 89, Pages: P172-P173, ISSN: 0141-0768
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  • Citations: 4
• Journal article
  MacCabe AP, vandenHombergh JPTW, Tilburn J, Arst HN, Visser Jet al., 1996,

  Identification, cloning and analysis of the Aspergillus niger gene pacC, a wide domain regulatory gene responsive to ambient pH

  , MOLECULAR AND GENERAL GENETICS, Vol: 250, Pages: 367-374, ISSN: 0026-8925
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  • Citations: 55

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