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  • Journal article
    Moffatt MF, James A, Ryan G, Musk AW, Cookson WOet al., 1999,

    Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample.

    , Thorax, Vol: 54, Pages: 757-761, ISSN: 0040-6376

    BACKGROUND: Tumour necrosis factor (TNF) is a potent pro-inflammatory cytokine which is prominent in asthmatic airways. TNF shows genetic variations in secretion which are linked to polymorphisms in the TNF gene complex and the surrounding major histocompatibility (MHC) locus. These polymorphisms do not seem to be themselves functionally important. In these circumstances, the identification of disease associated haplotypes (combination of alleles on individual chromosomes) may narrow the search for polymorphisms which alter gene function. METHODS: TNF-308, LTalpha NcoI, and HLA-DRB1 polymorphisms were investigated for association with asthma, bronchial responsiveness, and medication use in 1004 subjects in 230 families from a general population sample. RESULTS: The common LTalpha NcoI*1/TNF-308*2/HLA-DRB1*03 haplotype, which was present in 11% of unrelated individuals, was weakly associated with asthma (OR = 1.38, p = 0.016, corrected for familial correlation). The rarer LTalpha NcoI*1/TNF-308*2/HLA-DRB1*02 haplotype, which was found in 0.6% of unrelated subjects, was more strongly associated with asthma (OR = 6.68, p = 0.002). This haplotype also showed association with bronchial hyperresponsiveness (OR = 21.9, p = 0. 0000) and the use of inhaled or oral steroids (OR 8.0, p = 0.04). CONCLUSIONS: The results of this study show only two extended TNF/HLA-DR haplotypes to be associated with asthma. The search for functional alleles responsible for an increased risk of asthma should concentrate on the LTalpha NcoI*1/TNF-308*2/HLA-DRB1*02 haplotype.
  • Journal article
    Fisher MC, White TJ, Taylor JW, 1999,

    Primers for genotyping single nucleotide polymorphisms and microsatellites in the pathogenic fungus <i>Coccidioides immitis</i>

    , MOLECULAR ECOLOGY, Vol: 8, Pages: 1082-1084, ISSN: 0962-1083
  • Journal article
    Segers GC, Hamada W, Oliver RP, Spanu PDet al., 1999,

    Isolation and characterisation of five different hydrophobin-encoding cDNAs from the fungal tomato pathogen <i>Cladosporium fulvum</i>

    , MOLECULAR AND GENERAL GENETICS, Vol: 261, Pages: 644-652, ISSN: 0026-8925
  • Journal article
    Anderson GG, Cookson WO, 1999,

    Recent advances in the genetics of allergy and asthma.

    , Mol Med Today, Vol: 5, Pages: 264-273, ISSN: 1357-4310

    Asthma is a common condition that results from the interaction of an unknown number of genes with environmental factors. About 10% of children have asthma, usually as part of a syndrome of atopy, which is characterized by the presence of allergy, asthma, seasonal rhinitis and eczema, and tends to occur in familial clusters. The incidence of asthma is lower in adults (5%) and a significant proportion is seen without an atopic background. The prevalence of asthma has increased substantially over the past decades, particularly in the western world. Allergy and asthma are not inherited as single-gene disorders and do not show a simple pattern of inheritance. Environmental and genetic factors interact in a complex fashion to produce disease susceptibility and expression. Here, we describe the recent advances in the understanding of the inherited susceptibility to asthma and atopy and discuss their potential implications.
  • Journal article
    Hutchings H, Stahmann KP, Roels S, Espeso EA, Timberlake WE, Arst HN, Tilburn Jet al., 1999,

    The multiply-regulated <i>gabA</i> gene encoding the GABA permease of <i>Aspergillus nidulans</i>:: a score of exons

    , MOLECULAR MICROBIOLOGY, Vol: 32, Pages: 557-568, ISSN: 0950-382X
  • Journal article
    Moffatt MF, Cookson WO, 1999,

    Gene therapy for peanut allergy.

    , Nat Med, Vol: 5, Pages: 380-381, ISSN: 1078-8956
  • Journal article
    Alton EWFW, Stern M, Farley R, Jaffe A, Chadwick SL, Phillips J, Davies J, Smith SN, Browning J, Davies MG, Hodson ME, Durham SR, Li D, Jeffery PK, Scallan M, Balfour R, Eastman SJ, Cheng SH, Smith AE, Meeker D, Geddes DMet al., 1999,

    Cationic lipid-mediated <i>CFTR</i> gene transfer to the lungs and nose of patients with cystic fibrosis:: a double-blind placebo-controlled trial

    , LANCET, Vol: 353, Pages: 947-954, ISSN: 0140-6736
  • Journal article
    Dizier MH, James A, Faux J, Moffatt MF, Musk AW, Cookson W, Demenais Fet al., 1999,

    Segregation analysis of the specific response to allergens: A recessive major gene controls the specific IgE response to timothy grass pollen

    , Genetic Epidemiology, Vol: 16, Pages: 305-315, ISSN: 0741-0395

    Segregation analysis of the specific response to allergens (SRA) was performed in a sample of 234 randomly selected Australian families using the regressive models. Various SRA phenotypes were considered using broad and narrow definitions of these phenotypes, according to the type of test used, skin test or RAST test, and the specificity of the response to allergen. Strong evidence for familial dependencies among blood relatives was shown for most SRA phenotypes, especially when using a broad definition. There was no evidence for a Mendelian factor accounting for the familial transmission of these broadest phenotypes, which may involve multiple factors preventing the clear detection of a major effect with Mendelian transmission. However, segregation of a Mendelian recessive major gene was detected for one SRA sub- phenotype, the IgE response to a single allergen, Timothy grass pollen, measured by the RAST test. Identification of a specific SRA phenotype controlled by a major gene may have important implications for further linkage studies.
  • Journal article
    Ito K, Adcock I, Barnes PJ, 1999,

    Different histone acetylation induced by glucocorticoids and IL-1β in human epithelial cells (A549)

    , AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 159, Pages: A442-A442, ISSN: 1073-449X
  • Journal article
    Davies J, Dewar A, Bush A, Pitt T, Gruenert D, Geddes DM, Alton EWFWet al., 1999,

    Reduction in the adherence of <i>Pseudomonas aeruginosa</i> to native cystic fibrosis epithelium with anti-asialoGM1 antibody and neuraminidase inhibition

    , EUROPEAN RESPIRATORY JOURNAL, Vol: 13, Pages: 565-570, ISSN: 0903-1936

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