Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Conference paper
    Moffatt MF, Cookson WOCM, 1997,

    Linkage and candidate gene studies in asthma

    , Pages: S110-S112, ISSN: 1073-449X
    • Cite
    • Citations: 25
  • Journal article
    Sidhu PS, Desai SR, 1997,

    A simple and reproducible method for assessing intimal-medial thickness of the common carotid artery

    , BRITISH JOURNAL OF RADIOLOGY, Vol: 70, Pages: 85-89, ISSN: 0007-1285
  • Journal article
    Desai SR, Hansell DM, 1997,

    Lung imaging in the adult respiratory distress syndrome: Current practice and new insights

    , INTENSIVE CARE MEDICINE, Vol: 23, Pages: 7-15, ISSN: 0342-4642
    • Cite
    • Citations: 29
  • Journal article
    Davies J, Trindale M, Wallis C, Rosenthal M, Bush Aet al., 1997,

    The clinical use of rhDNAse

    , PEDIATRIC PULMONOLOGY, Pages: 273-274, ISSN: 8755-6863
  • Journal article
    Moffatt MF, Schou C, Faux JA, Cookson WOet al., 1997,

    Germline TCR-A restriction of immunoglobulin E responses to allergen.

    , Immunogenetics, Vol: 46, Pages: 226-230, ISSN: 0093-7711

    Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1(*)2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1(*)1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1(*)2 and HLA-DRB1(*)1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen.
  • Journal article
    Bismarck A, Tahhan R, Springer J, Schulz A, Klapotke TM, Zell H, Michaeli Wet al., 1997,

    Influence of fluorination on the properties of carbon fibers

    , Journal of Fluorine Chemistry, Vol: 84, Pages: 127-134
  • Journal article
    Davies J, Dewar A, Bush A, Geddes DM, Alton EWFWet al., 1996,

    Pseudomonas aeruginosa adherence to cystic fibrosis respiratory epithelium is reduced by anti-asialo GM1 antibody and neuraminidase inhibition

    , Thorax, Vol: 51, ISSN: 0040-6376

    Pseudomonas aeruginosa (P. aer), the bacterial pathogen responsible for most of the lung damage in cystic fibrosis (CF), adheres in greater numbers to cells of CF origin than to non-CF cells, which in part may explain the close relationship between this infection and CF. We have previously shown that this increased adherence results from the absence of normal CFTR, in that P. aer binding is reduced after in vitro liposome-mediated CFTR gene transfer. Previous studies have demonstrated that P. aer binds to asialylated glycolipids which are present in increased numbers on the surface of CF cells, and that neuraminidase, an exoproduct of P. aer, by cleaving sialic acid from glycolipids, can increase the availability of such binding sites. Mechanisms to reduce the adherence of P. aer to CF cells, thought to be the initial step in the process of infection, could potentially delay or prevent pulmonary colonisation and the deterioration in lung function which ensues. We have studied the possibility of reducing binding to asialo GM1 receptors, both by blocking with anti-asialo GM1 antibody, and with the inhibitor, 2,3-dehydo-2-deoxy-N-acetylneuraminic acid (DANA), to prevent neuraminidase-mediated increase in asialylated glycolipids. Nasal epithelial cells from 9 CF subjects were divided into 3 aliquots: each was exposed to a fixed concentration of a non-mucoid laboratory strain of P. aer (strain K), one aliquot after 1 hour incubation with a polyclonal rabbit anti-asialo GM1 antibody, and another in the presence of 50 μM DANA. A further 3 samples were used to study the affect of a control polyclonal anti-mouse antibody. Bacterial adherence to the apical surface of ciliated epithelial cells was quantified in a blinded fashion by direct visualisation using scanning electron microscopy. Pre-treatment with anti-asialo GM1 antibody resulted in a reduction in bacterial binding to every sample, with a mean reduction of 50% (mean binding /10 cells: baseline 9.7; anti-asialo GM1
  • Journal article
    Sugimoto N, Nakano S, Yoneyama M, Honda Ket al., 1996,

    Improved thermodynamic parameters and helix initiation factor to predict stability of DNA duplexes

    , NUCLEIC ACIDS RESEARCH, Vol: 24, Pages: 4501-4505, ISSN: 0305-1048
    • Cite
    • Citations: 402
  • Journal article
    Fisher MC, Viney ME, 1996,

    Microsatellites of the parasitic nematode Strongyloides ratti

    , MOLECULAR AND BIOCHEMICAL PARASITOLOGY, Vol: 80, Pages: 221-224, ISSN: 0166-6851
  • Journal article
    Daniels SE, Bhattacharrya S, James A, Leaves NI, Young A, Hill MR, Faux JA, Ryan GF, leSouef PN, Lathrop GM, Musk AW, Cookson WOCMet al., 1996,

    A genome-wide search for quantitative trait loci underlying asthma

    , NATURE, Vol: 383, Pages: 247-250, ISSN: 0028-0836
    • Cite
    • Citations: 631

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1255&limit=10&resgrpMemberPubs=true&resgrpMemberPubs=true&page=473&respub-action=search.html Current Millis: 1786361629466 Current Time: Mon Aug 10 12:33:49 BST 2026

General enquiries

 For any enquiries about the Fungal Science Network at Imperial, please contact:

fungalnetwork@imperial.ac.uk