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• Journal article
  SHAH AJ, TILBURN J, ADLARD MW, ARST HNet al., 1991,

  PH REGULATION OF PENICILLIN PRODUCTION IN ASPERGILLUS-NIDULANS

  , FEMS MICROBIOLOGY LETTERS, Vol: 77, Pages: 209-212, ISSN: 0378-1097
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  • Citations: 56
• Journal article
  Shah AJ, Tilburn J, Adlard MW, Arst HNet al., 1991,

  pH regulation of penicillin production in Aspergillus nidulans.

  , FEMS Microbiol Lett, Vol: 61, Pages: 209-212, ISSN: 0378-1097

  As shown by both bioassay and high-performance liquid chromatographic (HPLC) analysis, penicillin G production by Aspergillus nidulans is subject to regulation by the pH of the growth medium. Penicillin titres were highest at alkaline pH and in strains carrying mutations in the regulatory gene pacC which mimics the effects of growth at alkaline pH. They were lowest at acid pH and in strains carrying mutations in the palA, palB, palC, palE or palF genes which mimic the effects of growth at acid pH.

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• Journal article
  Hopkin JM, Cookson WO, Young RP, 1991,

  Asthma, atopy, and genetic linkage.

  , Ann N Y Acad Sci, Vol: 629, Pages: 26-30, ISSN: 0077-8923
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• Journal article
  CADDICK MX, ARST HN, 1990,

  NITROGEN REGULATION IN ASPERGILLUS - ARE 2 FINGERS BETTER THAN ONE

  , GENE, Vol: 95, Pages: 123-127, ISSN: 0378-1119
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  • Citations: 12
• Journal article
  Gardiner M, Sandford A, Deadman M, Poulton J, Cookson W, Reeders S, Jokiaho I, Peltonen L, Eiberg H, Julier Cet al., 1990,

  Batten disease (Spielmeyer-Vogt disease, juvenile onset neuronal ceroid-lipofuscinosis) gene (CLN3) maps to human chromosome 16.

  , Genomics, Vol: 8, Pages: 387-390, ISSN: 0888-7543

  The ceroid-lipofuscinoses are a group of inherited neurodegenerative disorders characterized by the accumulation of autofluorescent lipopigment in neurons and other cell types. The underlying biochemical defect is unknown. Batten disease (Spielmeyer-Vogt disease, juvenile onset neuronal ceroid-lipofuscinosis) displays autosomal recessive inheritance. Genetic linkage studies were undertaken to determine the chromosomal location of the Batten disease mutation (CLN3). Following identification of linkage to the haptoglobin locus, linkage analysis has been carried out in 42 families by using DNA markers for loci on the long arm of human chromosome 16. The maximal lod score between Batten disease and the locus D16S148 calculated for combined sexes is 6.05 at a recombination fraction theta = 0.00. Multilocus analysis using five loci indicated the most likely order to be HP-D16S151-D16S150-CLN3-D16S148-D16S147. The maximal location score for CLN3 was 48 (equivalent to a lod score of 10.4) in that interval within this fixed marker map.

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• Journal article
  SPANU P, FELIX G, BOLLER T, 1990,

  INACTIVATION OF STRESS-INDUCED 1-AMINOCYCLOPROPANE CARBOXYLATE SYNTHASE INVIVO DIFFERS FROM SUBSTRATE-DEPENDENT INACTIVATION INVITRO

  , PLANT PHYSIOLOGY, Vol: 93, Pages: 1482-1485, ISSN: 0032-0889
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  • Citations: 28
• Journal article
  ARST HN, HONDMANN DHA, VISSER J, 1990,

  A TRANSLOCATION ACTIVATING THE CRYPTIC NITROGEN REGULATION GENE AREB INACTIVATES A PREVIOUSLY UNIDENTIFIED GENE INVOLVED IN GLYCEROL UTILIZATION IN ASPERGILLUS-NIDULANS

  , MOLECULAR AND GENERAL GENETICS, Vol: 223, Pages: 134-137, ISSN: 0026-8925
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  • Citations: 15
• Journal article
  ARST HN, TOLLERVEY D, DOWZER CEA, KELLY JMet al., 1990,

  AN INVERSION TRUNCATING THE CREA GENE OF ASPERGILLUS-NIDULANS RESULTS IN CARBON CATABOLITE DEREPRESSION

  , MOLECULAR MICROBIOLOGY, Vol: 4, Pages: 851-854, ISSN: 0950-382X
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  • Citations: 67
• Journal article
  KUDLA B, CADDICK MX, LANGDON T, MARTINEZROSSI NM, BENNETT CF, SIBLEY S, DAVIES RW, ARST HNet al., 1990,

  THE REGULATORY GENE AREA MEDIATING NITROGEN METABOLITE REPRESSION IN ASPERGILLUS-NIDULANS - MUTATIONS AFFECTING SPECIFICITY OF GENE ACTIVATION ALTER A LOOP RESIDUE OF A PUTATIVE ZINC FINGER

  , EMBO JOURNAL, Vol: 9, Pages: 1355-1364, ISSN: 0261-4189
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  • Citations: 399
• Journal article
  de Klerk NH, Musk AW, James A, Glancy JJ, Cookson WOet al., 1990,

  Comparison of chest radiograph reading methods for assessing progress of pneumoconiosis over 10 years in Wittenoom crocidolite workers.

  , Br J Ind Med, Vol: 47, Pages: 127-131, ISSN: 0007-1072

  Thirty three pairs of chest radiographs taken up to 10 years apart were obtained for 33 subjects suffering from asbestosis who had applied for compensation to the Pneumoconiosis Medical Board of Western Australia. Multiple films from the period before the first radiograph in each pair, from the intervening period between the two, and from the period subsequent to the second radiograph were also available and all films were read by two independent readers according to the 1980 ILO classification of pneumoconiosis. Films were read twice as side by side pairs ten years apart, twice as two separate randomly ordered films ten years apart, and once as part of the full series of all available chest radiographs on each subject to assess which method provided the best consistency (between reader variation) and repeatability (within reader variation). Judging by consistency, the full series method performed as well as either of the other methods when assessing radiographic changes and significantly better when assessing the level of profusion of small opacities. There was little to choose between the other two methods either judging by consistency or repeatability, which could not be estimated for the full series method. Use of all available films for a subject is recommended for assessing single films, as in a prevalence study, as well as for documenting change in a longitudinal study.

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