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• Journal article
  Ito K, 2025,

  Can inhaled antifungals provide a viable solution for treatment-refractory pulmonary fungal infections?

  , EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, Vol: 23, Pages: 537-540, ISSN: 1478-7210
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• Journal article
  Khan AA, Vernugopan V, Wallis G, Feary Jet al., 2025,

  Artificial stone silicosis presenting as suspected Tuberculosis: A series of 3 cases at a district general hospital

  , Clinical Infection in Practice, Vol: 27

  Silicosis is an ancient condition re-emerging globally due to outbreaks of accelerated disease related to the use of artificial stone. The initial presentations of three patients with silicosis due to artificial stone exposure at a district general hospital in London, all of whom presented with clinical symptoms and radiological features assumed to be tuberculosis, are reported. The associations between silica exposure and this infection are also described. This series aims to highlight that artificial stone silicosis is now a significant occupational lung disease in the UK of which clinicians working in infectious diseases should be aware of.

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• Journal article
  Tanaka A, Filippidis F, El Asmar ML, Reed A, Morley-Smith A, Gerovasili Vet al., 2025,

  Pregnancy outcomes and management in lung and heart transplant recipients: a systematic review

  , JHLT Open, Vol: 9, ISSN: 2950-1334

  Immunosuppression advances have enabled organ transplant recipients to consider parenthood, but pregnancy poses risks to maternal and fetal health. This systematic review examines pregnancy outcomes and immunosuppression management in cardiothoracic transplant recipients. We conducted a literature search of PubMed/Medline, Embase, and Maternity & Infant Care Database in December 2022. We identified 54 relevant studies and data from the Transplant Pregnancy Registry International (TPRI), covering 404 pregnancies from 272 heart recipients (HTR) and 148 pregnancies from 121 lung recipients (LTR). Live births occurred in 74.3% of HTR and 65.5% of LTR pregnancies (22% preterm). Graft dysfunction developed in 11.5% (during) and 12.4% (after) of HTR pregnancies, and 17.6% (during) and 18% (after) of LTR pregnancies. Other complications included hypertension (HTR: 36.9%, LTR: 58.8%), preeclampsia (HTR: 19.7%, LTR: 12.2%), and diabetes (HTR: 11%, LTR: 27%). Mortality was 17.4% for HTR and 26.5% for LTR. Half of HTR and two-thirds of LTR were on Tacrolimus. Common immunosuppression changes included discontinuation of Mycophenolate Mofetil (MMF), Azathioprine, or Sirolimus with corticosteroid dose adjustment. Despite high successful pregnancy rates, HLTR may face substantial risks of graft dysfunction and maternal death post-pregnancy. (182 words)

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• Journal article
  Nishikawa M, Tang W, Kostrzewa M, Rodgus J, Davies F, Liu Y, Jauneikaite E, LarrouyMaumus Get al., 2025,

  Discrimination of Klebsiella pneumoniae and Klebsiella quasipneumoniae by MALDI-TOF mass spectrometry coupled with machine learning

  , MicrobiologyOpen, Vol: 14, ISSN: 2045-8827

  Klebsiella species, including Klebsiella pneumoniae and Klebsiella quasipneumoniae, present significant challenges in clinical microbiology due to their genetic similarity, which complicates accurate species identification using established methods, including matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) on the protein/peptide level. Although the treatment choice for infections caused by these pathogens is often similar, precise species characterization enhances our epidemiological understanding. While whole-genome sequencing can accurately distinguish Klebsiella species accurately, those analyses are time-consuming, requiring specialized expertise, and are not currently used in routine clinical laboratories. Therefore, developing a timely and accurate pathogen characterization method is essential for effective treatment, management, and infection control measures. This study combined MALDI-TOF MS in negative ion mode with machine learning techniques to identify potential lipid biomarkers as a novel method to distinguish between K. pneumoniae and K. quasipneumoniae. Using this method, we identified discriminative features between the species, with peaks at m/z 2157, m/z 1931, m/z 1964, m/z 2042, and m/z 1407 highlighted as potential biomarkers for species identification. Our findings suggest that the lipid profiles of the species obtained from MALDI-TOF MS can serve as effective biomarkers for distinguishing Klebsiella species. Further research should focus on the structural identification of these biomarkers and expand the data set to include more isolates for each of the species. This approach holds promise for developing more cost-effective and rapid diagnostic tools in clinical microbiology, ultimately improving patient outcomes and infection control.

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• Journal article
  Moon Y, Lee Y, Lee HJ, Byrne B, Chae PSet al., 2025,

  Unsymmetric or hybrid detergents for membrane protein structural study

  , Current Opinion in Structural Biology, Vol: 93, ISSN: 0959-440X

  Detergent micelles are widely used as a membrane-mimetic system for membrane protein extraction, isolation and structural study. Many recently developed detergents feature multiple tail and head groups, with architectures that are symmetric (i.e. the same alkyl chain) and non-hybrid (single head group type). Further diversification has involved incorporating structural differences in the tail groups (unsymmetric), head groups (hybrid), or both head and tail groups (unsymmetric hybrid). In this mini-review, we introduce these novel detergents, focusing on the relationships between their structural features, physical properties and performance in membrane protein applications. The detergent design strategy utilizing unsymmetric/hybrid structures expands the detergent repertoire and the detergent structure–property-efficacy relationships presented offer valuable design guidelines, collectively advancing membrane protein research.

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• Journal article
  Wang X, Sun M-L, Lin L, Ledesma-Amaro R, Wang K, Ji X-Jet al., 2025,

  Engineering strategies for producing medium-long chain dicarboxylic acids in oleaginous yeasts

  , Bioresource Technology, Vol: 430, ISSN: 0960-8524

  Medium-long chain dicarboxylic acids (DCAs, C ≥ 6) are essential chemical raw materials, with wide applications in the chemical, pharmaceutical, material and food industries. However, the traditional chemical synthesis methods cause environmental pollution and are not in line with goals of sustainable development. With the development of synthetic biology, high-value-added DCAs can be biosynthesized from hydrophobic substrates (HSs) using suitable microorganisms. This review first summarizes the biosynthetic pathway of DCAs in oleaginous yeasts and then emphasizes the related engineering strategies for increasing the product yield, including promoter, enzyme, pathway, cell, fermentation, and downstream engineering. In addition, the challenges and development trends in the biosynthesis of DCAs are discussed, in light of the current progress, challenges, and trends in this field. Finally, guidelines for future research are proposed. Overall, this review systematically summarizes recent engineering strategies for DCAs production in oleaginous yeasts and offers valuable insights for future DCAs biosynthesis.

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• Journal article
  Morris AJ, McKinney WP, Roberts SA, Sithamparanathan S, Chaudhry Z, Fisher MCet al., 2025,

  Appearance of environment‐linked azole resistance in the Aspergillus fumigatus complex in New Zealand

  , Mycoses, Vol: 68, ISSN: 0933-7407

  BackgroundUntil 2020, azole resistance in Aspergillus fumigatus complex isolates in New Zealand was due to cyp51A hot spot mutations. This report details the appearance of environment-linked tandem repeat (TR)-related azole resistance genotypes since 2021.MethodsIsolates were tested by broth micro-dilution. Clinical Laboratory Standards Institute criteria were used to define wild type (WT) and non-wild type (non-WT) isolates, which were identified by ß-tubulin gene sequencing and had their cyp51A genotype for azole resistance determined. Whole genome sequencing (WGS) was applied to two patient pairs of sequential WT and non-WT isolates.ResultsFrom January 2021 to June 2024, 15 of 147 (10.2%) A. fumigatus complex isolates were resistant or non-WT for one or more azole agents. Genotyping detected hot spot mutations in four and TR-associated resistance in nine. No mutations were detected in two isolates. Four of the five TR46 mutations were TR46/Y121F/T289A. Three of the four TR34 mutations were different. WGS of the paired isolates showed that the non-WT isolates were distinct. Azole-containing fungicides are available for home use from garden centres. Patients with TR-associated resistance did not have any obvious exposure to azole-containing fungicides. There was no evidence for healthcare-acquired transmission.ConclusionsA. fumigatus sensu stricto isolates with TR-mutations linked to environmental resistance are now present in New Zealand. Those at risk of invasive A. fumigatus infection should receive advice to avoid high-risk exposures. Reintroducing monitoring of azole-containing fungicides is recommended.

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• Journal article
  Lawrence J, O'Hare D, van Batenburg-Sherwood J, d'Arc S, Davies F, Bock L, Sutton JM, Holmes A, Rawson TMet al., 2025,

  Towards real-time in vitro<i> Enterobacteriaceae</i> beta-lactamase quantification using iridium oxide-based biosensors

  , JOURNAL OF INFECTION, Vol: 91, ISSN: 0163-4453
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• Journal article
  Thng KX, Tiew PY, Mac Aogain M, Narayana JK, Jaggi TK, Ivan FX, Shuttleworth M, Long MB, Richardson H, Lind H, Headley DADL, Robertson K, Pollock J, Goeminne PC, Shteinberg M, De Soyza A, Aliberti S, Altenburg J, Haworth CS, Sibila O, Polverino E, Loebinger MR, Ringshausen FC, Lorent N, Dimakou K, Shoemark A, Chalmers JD, Chotirmall SHet al., 2025,

  Sputum metagenomics in bronchiectasis reveals pan-European variation: an EMBARC-BRIDGE study

  , EUROPEAN RESPIRATORY JOURNAL, Vol: 66, ISSN: 0903-1936
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• Journal article
  Matson SM, Molyneaux PL, 2025,

  Blurred Boundaries: Rethinking Disease Classifications in Interstitial Lung Disease Using Molecular Signals.

  , Am J Respir Crit Care Med, Vol: 211, Pages: 1333-1334
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