@article{Durham:1988:10.1016/0091-6749(88)90077-2,
author = {Durham, SR and Craddock, CF and Cookson, WO and Benson, MK},
doi = {10.1016/0091-6749(88)90077-2},
journal = {J Allergy Clin Immunol},
pages = {764--770},
title = {Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses.},
url = {http://dx.doi.org/10.1016/0091-6749(88)90077-2},
volume = {82},
year = {1988}
}

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TY  - JOUR
AB  - Changes in airway responsiveness to histamine after allergen inhalation challenge were studied in 14 nonsmoking atopic adult subjects with asthma. Inhalation challenges with allergen and with phosphate-buffered saline (control challenge) were performed single blind in random order, with an interval of 14 days. The development of a late asthmatic response was accompanied by an increase in airway histamine responsiveness that was significant when it was compared with the airway histamine responsiveness after the control challenge at 3 hours (p less than 0.01), 24 hours (p less than 0.01), and 48 hours (p less than 0.02), with recovery at 2 weeks after allergen inhalation. The 3-hour changes in airway responsiveness occurred independently of changes in airway caliber and correlated with the magnitude of the subsequent late response (r = 0.86; p less than 0.001). These results suggest that the tissue events (possibly airway inflammation) that underlie the late asthmatic response may occur before this response becomes clinically apparent.
AU  - Durham,SR
AU  - Craddock,CF
AU  - Cookson,WO
AU  - Benson,MK
DO  - 10.1016/0091-6749(88)90077-2
EP  - 770
PY  - 1988///
SN  - 0091-6749
SP  - 764
TI  - Increases in airway responsiveness to histamine precede allergen-induced late asthmatic responses.
T2  - J Allergy Clin Immunol
UR  - http://dx.doi.org/10.1016/0091-6749(88)90077-2
UR  - https://www.ncbi.nlm.nih.gov/pubmed/3192861
VL  - 82
ER  - 

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