In this section
@article{Shirakawa:1994:10.1038/ng0694-125,
author = {Shirakawa, T and Li, A and Dubowitz, M and Dekker, JW and Shaw, AE and Faux, JA and Ra, C and Cookson, WO and Hopkin, JM},
doi = {10.1038/ng0694-125},
journal = {Nat Genet},
pages = {125--129},
title = {Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.},
url = {http://dx.doi.org/10.1038/ng0694-125},
volume = {7},
year = {1994}
}
TY - JOUR
AB - The beta-subunit of the high-affinity IgE receptor (Fc epsilon RI-beta) on chromosome 11 is maternally linked to atopy, the state of enhanced IgE responsiveness underlying allergic asthma and rhinitis. We have identified a common variant of Fc epsilon RI-beta, lle181Leu within the 4th transmembrane domain. Leu181 shows significant association with positive IgE responses in a random patient sample. Amongst 60 unrelated nuclear families with allergic asthmatic probands, Leu181 is identified in 10 (17%), is maternally inherited in each, and shows a strong association with atopy. Our data indicate that Fc epsilon RI-beta, subject to maternal modification, may be the atopy-causing locus on chromosome 11q.
AU - Shirakawa,T
AU - Li,A
AU - Dubowitz,M
AU - Dekker,JW
AU - Shaw,AE
AU - Faux,JA
AU - Ra,C
AU - Cookson,WO
AU - Hopkin,JM
DO - 10.1038/ng0694-125
EP - 129
PY - 1994///
SN - 1061-4036
SP - 125
TI - Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor.
T2 - Nat Genet
UR - http://dx.doi.org/10.1038/ng0694-125
UR - https://www.ncbi.nlm.nih.gov/pubmed/7920628
VL - 7
ER -
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