Citation

BibTex format

@article{Evans:2022:10.1016/s2213-2600(22)00127-8,
author = {Evans, RA and Leavy, OC and Richardson, M and Elneima, O and McCauley, HJC and Shikotra, A and Singapuri, A and Sereno, M and Saunders, RM and Harris, VC and Houchen-Wolloff, L and Aul, R and Beirne, P and Bolton, CE and Brown, JS and Choudhury, G and Diar-Bakerly, N and Easom, N and Echevarria, C and Fuld, J and Hart, N and Hurst, J and Jones, MG and Parekh, D and Pfeffer, P and Rahman, NM and Rowland-Jones, SL and Shah, AM and Wootton, DG and Chalder, T and Davies, MJ and De, Soyza A and Geddes, JR and Greenhalf, W and Greening, NJ and Heaney, LG and Heller, S and Howard, LS and Jacob, J and Jenkins, RG and Lord, JM and Man, WD-C and McCann, GP and Neubauer, S and Openshaw, PJM and Porter, JC and Rowland, MJ and Scott, JT and Semple, MG and Singh, SJ and Thomas, DC and Toshner, M and Lewis, KE and Thwaites, RS and Briggs, A and Docherty, AB and Kerr, S and Lone, NI and Quint, J and Sheikh, A and Thorpe, M and Zheng, B and Chalmers, JD and Ho, LP and Horsley, A and Marks, M and Poinas},
doi = {10.1016/s2213-2600(22)00127-8},
journal = {The Lancet Respiratory Medicine},
pages = {761--775},
title = {Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study},
url = {http://dx.doi.org/10.1016/s2213-2600(22)00127-8},
volume = {10},
year = {2022}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BackgroundNo effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge for COVID-19, identify factors associated with patient-perceived recovery, and identify potential therapeutic targets by describing the underlying inflammatory profiles of the previously described recovery clusters at 5 months after hospital discharge.MethodsThe Post-hospitalisation COVID-19 study (PHOSP-COVID) is a prospective, longitudinal cohort study recruiting adults (aged ≥18 years) discharged from hospital with COVID-19 across the UK. Recovery was assessed using patient-reported outcome measures, physical performance, and organ function at 5 months and 1 year after hospital discharge, and stratified by both patient-perceived recovery and recovery cluster. Hierarchical logistic regression modelling was performed for patient-perceived recovery at 1 year. Cluster analysis was done using the clustering large applications k-medoids approach using clinical outcomes at 5 months. Inflammatory protein profiling was analysed from plasma at the 5-month visit. This study is registered on the ISRCTN Registry, ISRCTN10980107, and recruitment is ongoing.Findings2320 participants discharged from hospital between March 7, 2020, and April 18, 2021, were assessed at 5 months after discharge and 807 (32·7%) participants completed both the 5-month and 1-year visits. 279 (35·6%) of these 807 patients were women and 505 (64·4%) were men, with a mean age of 58·7 (SD 12·5) years, and 224 (27·8%) had received invasive mechanical ventilation (WHO class 7–9). The proportion of patients reporting full recovery was unchanged between 5 months (501 [25·5%] of 1965) and 1 year (232 [28·9%] of 804). Factors associated with being less likely to report full recovery at 1 year were female sex (odds ratio 0·68 [95% CI 0·46–0·99]), obes
AU - Evans,RA
AU - Leavy,OC
AU - Richardson,M
AU - Elneima,O
AU - McCauley,HJC
AU - Shikotra,A
AU - Singapuri,A
AU - Sereno,M
AU - Saunders,RM
AU - Harris,VC
AU - Houchen-Wolloff,L
AU - Aul,R
AU - Beirne,P
AU - Bolton,CE
AU - Brown,JS
AU - Choudhury,G
AU - Diar-Bakerly,N
AU - Easom,N
AU - Echevarria,C
AU - Fuld,J
AU - Hart,N
AU - Hurst,J
AU - Jones,MG
AU - Parekh,D
AU - Pfeffer,P
AU - Rahman,NM
AU - Rowland-Jones,SL
AU - Shah,AM
AU - Wootton,DG
AU - Chalder,T
AU - Davies,MJ
AU - De,Soyza A
AU - Geddes,JR
AU - Greenhalf,W
AU - Greening,NJ
AU - Heaney,LG
AU - Heller,S
AU - Howard,LS
AU - Jacob,J
AU - Jenkins,RG
AU - Lord,JM
AU - Man,WD-C
AU - McCann,GP
AU - Neubauer,S
AU - Openshaw,PJM
AU - Porter,JC
AU - Rowland,MJ
AU - Scott,JT
AU - Semple,MG
AU - Singh,SJ
AU - Thomas,DC
AU - Toshner,M
AU - Lewis,KE
AU - Thwaites,RS
AU - Briggs,A
AU - Docherty,AB
AU - Kerr,S
AU - Lone,NI
AU - Quint,J
AU - Sheikh,A
AU - Thorpe,M
AU - Zheng,B
AU - Chalmers,JD
AU - Ho,LP
AU - Horsley,A
AU - Marks,M
AU - Poinasamy,K
AU - Raman,B
AU - Harrison,EM
AU - Wain,LV
AU - Brightling,CE
AU - Abel,K
AU - Adamali,H
AU - Adeloye,D
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AU - Ainsworth,M
AU - Al-Sheklly,B
AU - Alamoudi,A
AU - Ali,M
AU - Aljaroof,M
AU - All,AM
AU - Allan,L
AU - Allen,RJ
AU - Allerton,L
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AU - Almeida,P
AU - Altmann,D
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AU - Amoils,S
AU - Anderson,D
AU - Antoniades,C
AU - Arbane,G
AU - Arias,A
AU - Armour,C
AU - Armstrong,L
AU - Armstrong,N
AU - Arnold,D
AU - Arnold,H
AU - Ashish,A
AU - Ashworth,A
AU - Ashworth,M
AU - Aslani,S
AU - Assefa-Kebede,H
AU - Atkin,C
AU - Atkin,P
AU - Aung,H
AU - Austin,L
AU - Avram,C
AU - Ayoub,A
AU - Babores,M
AU - Baggott,R
AU - Bagshaw,J
AU - Baguley,D
AU - Bailey,L
AU - Baillie,JK
AU - Bain,S
AU - Bakali,M
AU - Bakau,M
AU - Baldry,E
AU - Baldwin,D
AU - Ballard,C
AU - Banerjee,A
AU - Bang,B
AU - Barker,RE
AU - Barman,L
AU - Barratt,S
AU - Barrett,F
AU - Basire,D
AU - Basu,N
AU - Bates,M
AU - Bates,A
AU - Batterham,R
AU - Baxendale,H
AU - Bayes,H
AU - Beadsworth,M
AU - Beckett,P
AU - Beggs,M
AU - Begum,M
AU - Bell,D
AU - Bell,R
AU - Bennett,K
AU - Beranova,E
AU - Bermperi,A
AU - Berridge,A
AU - Berry,C
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AU - Breen,G
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AU - Bright,E
AU - Brill,S
AU - Brindle,K
AU - Broad,L
AU - Broadley,A
AU - Brookes,C
AU - Broome,M
AU - Brown,A
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AU - Brown,M
AU - Brown,V
AU - Brugha,T
AU - Brunskill,N
DO - 10.1016/s2213-2600(22)00127-8
EP - 775
PY - 2022///
SN - 2213-2600
SP - 761
TI - Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
T2 - The Lancet Respiratory Medicine
UR - http://dx.doi.org/10.1016/s2213-2600(22)00127-8
UR - https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00127-8/fulltext
UR - http://hdl.handle.net/10044/1/97384
VL - 10
ER -