@article{Sandhu:2023:10.1152/japplphysiol.00744.2022,
author = {Sandhu, D and Redmond, JL and Smith, NMJ and Short, C and Saunders, CJ and Couper, JH and Fullerton, CJ and Richmond, G and Talbot, NP and Davies, JC and Ritchie, GAD and Robbins, PA},
doi = {10.1152/japplphysiol.00744.2022},
journal = {Journal of Applied Physiology},
pages = {205--216},
title = {Computed cardiopulmonography and the idealized lung clearance index, iLCI2.5, in early-stage cystic fibrosis.},
url = {http://dx.doi.org/10.1152/japplphysiol.00744.2022},
volume = {135},
year = {2023}
}

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TY  - JOUR
AB  - This study explored the use of computed cardiopulmonography (CCP) to assess lung function in early-stage cystic fibrosis (CF). CCP has two components. The first is a particularly accurate technique for measuring gas exchange. The second is a computational cardiopulmonary model where patient-specific parameters can be estimated from the measurements of gas exchange. Twenty-five participants (14 healthy controls, 11 early-stage CF) were studied with CCP. They were also studied with a standard clinical protocol to measure the lung clearance index (LCI2.5). Ventilation inhomogeneity, as quantified through CCP parameter σlnCl, was significantly greater (P < 0.005) in CF than in controls, and anatomical deadspace relative to predicted functional residual capacity (DS/FRCpred) was significantly more variable (P < 0.002). Participant-specific parameters were used with the CCP model to calculate idealized values for LCI2.5 (iLCI2.5) where extrapulmonary influences on the LCI2.5, such as breathing pattern, had all been standardized. Both LCI2.5 and iLCI2.5 distinguished clearly between CF and control participants. LCI2.5 values were mostly higher than iLCI2.5 values in a manner dependent on the participant's respiratory rate (r = 0.46, P < 0.05). The within-participant reproducibility for iLCI2.5 appeared better than for LCI2.5, but this did not reach statistical significance (F ratio = 2.2, P = 0.056). Both a sensitivity analysis on iLCI2.5 and a regression analysis on LCI2.5 revealed that these depended primarily on an interactive term between CCP parameters of the form σlnCL(DS/FRC). In conclusion, the LCI2.5 (or iLCI2.5) probably reflects an amalgam of different underlying lung changes in early-stage CF that would require a multiparameter approach, such as potentially CCP, to resolve.NEW & NOTEWORTHY Computed cardiopulmonography is a new technique comprising a highly accurate sensor for measuring respiratory gas exchange coupled with a cardiopulm
AU  - Sandhu,D
AU  - Redmond,JL
AU  - Smith,NMJ
AU  - Short,C
AU  - Saunders,CJ
AU  - Couper,JH
AU  - Fullerton,CJ
AU  - Richmond,G
AU  - Talbot,NP
AU  - Davies,JC
AU  - Ritchie,GAD
AU  - Robbins,PA
DO  - 10.1152/japplphysiol.00744.2022
EP  - 216
PY  - 2023///
SN  - 1522-1601
SP  - 205
TI  - Computed cardiopulmonography and the idealized lung clearance index, iLCI2.5, in early-stage cystic fibrosis.
T2  - Journal of Applied Physiology
UR  - http://dx.doi.org/10.1152/japplphysiol.00744.2022
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37262105
UR  - https://journals.physiology.org/doi/full/10.1152/japplphysiol.00744.2022
UR  - http://hdl.handle.net/10044/1/105382
VL  - 135
ER  - 

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