In this section
@article{Leaves:2002:10.1038/sj.ejhg.5200787,
author = {Leaves, NI and Bhattacharyya, S and Wiltshire, S and Cookson, WOCM},
doi = {10.1038/sj.ejhg.5200787},
journal = {Eur J Hum Genet},
pages = {177--182},
title = {A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.},
url = {http://dx.doi.org/10.1038/sj.ejhg.5200787},
volume = {10},
year = {2002}
}
TY - JOUR
AB - Non-specific bronchial hyper-responsiveness to various inhaled stimuli is a characteristic of asthma. We have previously shown linkage of bronchial responsiveness to methacholine (measured as dose-response slope (DRS)) and the peripheral blood eosinophil count (EOS) to chromosome 7. We have now further investigated these linkages by genotyping 49 microsatellite markers across the DRS locus on chromosome 7. The markers were spaced on average 2.6 cM apart and spanned a sex averaged cumulative genetic distance of 129 cM. Multipoint linkage to DRS was bimodal and dipped at the centromere. The two peaks of linkage were close to markers D7S484 (P=0.0003) and D7S669 (P=0.006) respectively. Separate testing for linkage to paternally and maternally derived alleles showed that the linkage near D7S484 was paternally derived (P<0.00001): maternally derived alleles did not exhibit significant linkage. The results indicate that two disparate loci may be influencing asthma from chromosome 7.
AU - Leaves,NI
AU - Bhattacharyya,S
AU - Wiltshire,S
AU - Cookson,WOCM
DO - 10.1038/sj.ejhg.5200787
EP - 182
PY - 2002///
SN - 1018-4813
SP - 177
TI - A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.
T2 - Eur J Hum Genet
UR - http://dx.doi.org/10.1038/sj.ejhg.5200787
UR - https://www.ncbi.nlm.nih.gov/pubmed/11973621
VL - 10
ER -
For any enquiries about the Fungal Science Network at Imperial, please contact: