Results
- Showing results for:
- Reset all filters
Search results
-
Journal articleHallett JP, 2024,
Green chemistry startups: some lessons learned
, GREEN CHEMISTRY, Vol: 27, Pages: 403-412, ISSN: 1463-9262 -
Journal articleRafat AA, Barbara PV, Ullah A, et al., 2024,
Efficient extraction of carboxylated nanocellulose from ionoSolv pulps with alkaline H<sub>2</sub>O<sub>2</sub> assisted oxidation
, CELLULOSE, ISSN: 0969-0239 -
Journal articleGreen S, Broderick H, Wheelhouse KMP, et al., 2024,
Continuous preparation and reaction of nonaflyl azide (NfN3) for the synthesis of organic azides and 1,2,3-triazoles
, Journal of Flow Chemistry, Vol: 14, Pages: 559-568, ISSN: 2062-249XOrganic azides are widely used in organic synthesis. Continuous flow processing can be used to bypass their isolation, and can therefore be useful in mitigating the hazards associated with these potentially toxic and explosive reagents. Nonaflyl azide has been reported as an effective, bench-stable, and relatively safe diazo transfer reagent that can be useful in the preparation of azides from amines and so avoid the use of alkyl halides. Here we demonstrate the synthesis and purification of nonaflyl azide in continuous flow with isolation of the neat, pure reagent by membrane filtration. The neat reagent was used in the preparation of organic azides from primary amines, and then applied to the synthesis of triazoles. A variety of triazoles, including the antiseizure drug Rufinamide, were prepared from primary amines and alkynes via the CuAAC click reaction in a semi-batch parallel array without isolation of alkyl azide intermediates. A telescoped two-stage continuous flow process was also designed and demonstrated to form triazoles via the same CuAAC reaction, which avoids the handling of the intermediate reactive azides.
-
Journal articlePolesca C, Passos H, Nakasu PYS, et al., 2024,
Ionic-liquid-processed keratin-based biocomposite films with cellulose and chitin for sustainable dye removal
, RSC SUSTAINABILITY, Vol: 2, Pages: 2239-2248 -
Journal articleZhu Y, Hallett J, 2024,
Ionic-liquid-based technologies for waste management
, NATURE CHEMICAL ENGINEERING, Vol: 1, Pages: 444-445 -
Journal articleLei Z, Dai C, Hallett J, et al., 2024,
Introduction: Ionic Liquids for Diverse Applications
, CHEMICAL REVIEWS, Vol: 124, Pages: 7533-7535, ISSN: 0009-2665 -
Journal articleFirth AEJ, Nakasu PYS, Fennell PS, et al., 2024,
An Ionic Liquid-Based Biorefinery Approach for Duckweed Utilization.
, ACS Sustain Resour Manag, Vol: 1, Pages: 842-856This study establishes a foundation for the ionic liquid (IL) pretreatment of duckweed biomass. An optimized IL-based process was designed to exploit the unique properties of duckweed including efficient metal removal, potential starch accumulation, and protein accumulation. Two ILs, namely, dimethylethanolammonium formate ([DMEtA][HCOO]) and N,N-dimethylbutylammonium hydrogen sulfate ([DMBA][HSO4]), were investigated for the pretreatment of two duckweed species (Spirodela polyrhiza and Lemna minor). The evaluation focused on starch recovery, sugar release, protein recovery, and metal extraction capabilities. [DMEtA][HCOO] demonstrated near-quantitative starch recoveries at 120 °C, while [DMBA][HSO4] showed similar performance at 90 °C within a reaction time of 2 h. Saccharification yields for most pulps exceeded 90% after 8 h of hydrolysis, outperforming "traditional" lignocellulosic biomasses such as miscanthus or sugarcane bagasse. Approximately 50 and 80 wt % of the protein were solubilized in [DMEtA][HCOO] and [DMBA][HSO4], respectively, while the remaining protein distributed between the pulp and lignin. However, the solubilized protein in the IL could not be recovered due to its low molecular weight. Regarding metal extraction, [DMEtA][HCOO] demonstrated higher efficiency, achieving 81% removal of Ni from Lemna minor's pulps, whereas [DMBA][HSO4] extracted only 28% of Ni with slightly higher pulp concentrations. These findings indicate the need for further optimization in concurrent metal extraction using ILs.
-
Journal articleHou X, Feng G, Chen Z, et al., 2024,
Tailoring a suitable partner system for cholinium cation to build effective solvents for biomass deconstruction
, GREEN CHEMISTRY, Vol: 26, Pages: 5977-5987, ISSN: 1463-9262 -
Journal articleConstantinou AP, Nele V, Doutch JJ, et al., 2024,
ABC block copolymer micelles driving the thermogelation: scattering, imaging and spectroscopy
, Polymer, Vol: 302, ISSN: 0032-3861Thermoresponsive polymers have attracted much scientific attention due to their capacity for temperature-driven hydrogel formation. For biomedical applications, such as drug delivery, this transition should be tuned below body temperature to facilitate controlled and targeted drug release. We have recently developed a thermoresponsive polymer that forms gel at low concentrations (2 w/w%) in aqueous media and offers a cost-effective alternative to thermoresponsive systems currently being applied in clinics. This polymer is an ABC triblock terpolymer, where A, B, and C correspond to oligo(ethylene glycol) methyl ether methacrylate with average Mn 300 g mol−1 (OEGMA300), n-butyl methacrylate (BuMA), and di(ethylene glycol) methyl ether methacrylate (DEGMA). To investigate the self-assembly and the gelation mechanism in diluted solutions, we used small-angle neutron scattering (SANS) on 1 w/w% (below the gelation concentration) and 5 w/w% solutions (above the gelation concentration). As a comparison, we also investigated the solutions of the most studied thermoresponsive polymer, namely, Pluronic F127, an ABA triblock bipolymer made of ethylene glycol (A) and propylene glycol (B) blocks. SANS revealed that the in-house synthesised polymer forms elliptical cylinders, whose length increases significantly with temperature. In contrast, Pluronic F127 solutions form core-shell spherical micelles, which slightly elongate with temperature. Transmission electron microscopy images support the SANS findings, with tubular/worm structures being present. Variable-temperature circular dichroism (CD) and proton nuclear magnetic resonance (1H NMR) spectroscopy experiments reveal insights on the tacticity, structural changes, and molecular origin of the self-assembly.
-
Journal articleChen Y, Lin X, Liu X, et al., 2024,
Thermally robust solvent-free liquid polyplexes for heat-shock protection and long-term room temperature storage of therapeutic nucleic acids
, Biomacromolecules, Vol: 25, Pages: 2965-2972, ISSN: 1525-7797Nucleic acid therapeutics have attracted recent attention as promising preventative solutions for a broad range of diseases. Nonviral delivery vectors, such as cationic polymers, improve the cellular uptake of nucleic acids without suffering the drawbacks of viral delivery vectors. However, these delivery systems are faced with a major challenge for worldwide deployment, as their poor thermal stability elicits the need for cold chain transportation. Here, we demonstrate a biomaterial strategy to drastically improve the thermal stability of DNA polyplexes. Importantly, we demonstrate long-term room temperature storage with a transfection efficiency maintained for at least 9 months. Additionally, extreme heat shock studies show retained luciferase expression after heat treatment at 70 °C. We therefore provide a proof of concept for a platform biotechnology that could provide long-term room temperature storage for temperature-sensitive nucleic acid therapeutics, eliminating the need for the cold chain, which in turn would reduce the cost of distributing life-saving therapeutics worldwide.
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.