Publications

Journal article

Nakasu PYS, Martinez MA, Melanie S, Shmool TA, Hallett JPet al., 2025,

Chitosan-Based Biocomposite Hydrogels with Squid Pen Protein for Anionic Dyes Adsorption

, ACS MATERIALS LETTERS, Vol: 7, Pages: 1012-1018

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Citations: 3

Journal article

Nakasu PYS, Piccoli V, Ovejero-Perez A, Kumar P, Al Ghatta A, Melanie S, Polesca C, Martinez L, Hallett JPet al., 2025,

Fractionation of Squid Pens with Ionic Liquids―An Upgraded β-Chitin and Shellfish Protein Production

, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, Vol: 13, Pages: 2649-2660, ISSN: 2168-0485

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Citations: 1

Book chapter

S Nakasu PY, Hopson C, Ovejero-Pérez A, Costa JM, Hallett JPet al., 2025,

Ionic Liquids and Their Role in a Lignocellulosic Biorefinery

, Encyclopedia of Green Chemistry First Edition Volume 1 4, Pages: V4-140

Ionic liquids (ILs), outstanding solvents for modifying lignocellulosic biomass, offer high biomass fractionation, yielding purer cellulosic and lignin fractions. The main benefits of ILs compared with other processes are the high degree of biomass fractionation and possibility of solvent recycle and reuse. While direct hemicellulose extraction remains a challenge, ILs facilitate the production of biobased platform chemicals through biochemical, chemical, and thermochemical routes. Aprotic ILs, despite high cellulose solubility, face cost barriers. In contrast, protic ILs, more cost-effective, efficiently solubilize lignin or both lignin and hemicelluloses. However, challenges such as scale-up, equipment corrosion, and IL recovery hinder the environmental and economic viability of IL-based biorefineries.

Abstract
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Citations: 2

Book chapter

S Nakasu PY, Hopson C, Ovejero-Pérez A, Costa JM, Hallett JPet al., 2025,

Ionic Liquids and Their Role in a Lignocellulosic Biorefinery

, Encyclopedia of Green Chemistry, Publisher: Elsevier, Pages: 125-140, ISBN: 9780443289231

Journal article

Hallett JP, 2024,

Green chemistry startups: some lessons learned

, GREEN CHEMISTRY, Vol: 27, Pages: 403-412, ISSN: 1463-9262

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Journal article

Rafat AA, Barbara PV, Ullah A, Kontturi E, Law RV, Hallett JPet al., 2024,

Efficient extraction of carboxylated nanocellulose from ionoSolv pulps with alkaline H<sub>2</sub>O<sub>2</sub> assisted oxidation

, CELLULOSE, ISSN: 0969-0239

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Journal article

Green S, Broderick H, Wheelhouse KMP, Hallett J, Miller P, Bull Jet al., 2024,

Continuous preparation and reaction of nonaflyl azide (NfN3) for the synthesis of organic azides and 1,2,3-triazoles

, Journal of Flow Chemistry, Vol: 14, Pages: 559-568, ISSN: 2062-249X

Organic azides are widely used in organic synthesis. Continuous flow processing can be used to bypass their isolation, and can therefore be useful in mitigating the hazards associated with these potentially toxic and explosive reagents. Nonaflyl azide has been reported as an effective, bench-stable, and relatively safe diazo transfer reagent that can be useful in the preparation of azides from amines and so avoid the use of alkyl halides. Here we demonstrate the synthesis and purification of nonaflyl azide in continuous flow with isolation of the neat, pure reagent by membrane filtration. The neat reagent was used in the preparation of organic azides from primary amines, and then applied to the synthesis of triazoles. A variety of triazoles, including the antiseizure drug Rufinamide, were prepared from primary amines and alkynes via the CuAAC click reaction in a semi-batch parallel array without isolation of alkyl azide intermediates. A telescoped two-stage continuous flow process was also designed and demonstrated to form triazoles via the same CuAAC reaction, which avoids the handling of the intermediate reactive azides.

Journal article

Polesca C, Passos H, Nakasu PYS, Coutinho JAP, Freire MG, Hallett JPet al., 2024,