The Centre has a long history of developing new techniques for medical imaging (particularly in magnetic resonance imaging), transforming them from a primarily diagnostic modality into an interventional and therapeutic platform. This is facilitated by the Centre's strong engineering background in practical imaging and image analysis platform development, as well as advances in minimal access and robotic assisted surgery. Hamlyn has a strong tradition in pursuing basic sciences and theoretical research, with a clear focus on clinical translation.

In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting during surgical intervention, our recent research has also been focussed on novel biophotonics platforms that can be used for real-time tissue characterisation, functional assessment, and intraoperative guidance during minimally invasive surgery. This includes, for example, SMART confocal laser endomicroscopy, time-resolved fluorescence spectroscopy and flexible FLIM catheters.


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  • Journal article
    Vander Poorten E, Tran P, Devreker A, Gruijthuijsen C, Portoles-Diez S, Smoljkic G, Strbac V, Famaey N, Reynaerts D, Vander Sloten J, Tibebu A, Yu B, Rauch C, Bernard F, Kassahun Y, Metzen JH, Giannarou S, Zhao L, Lee S, Yang G, Mazomenos E, Chang P, Stoyanov D, Kvasnytsia M, Van Deun J, Verhoelst E, Sette M, Di Iasio A, Leo G, Hertner F, Scherly D, Chelini L, Häni N, Seatovic D, Rosa B, De Praetere H, Herijgers Pet al., 2016,

    Cognitive Autonomous Catheters Operating in Dynamic Environments

    , Journal of Medical Robotics Research, Vol: 01, ISSN: 2424-905X

    Advances in miniaturized surgical instrumentation are key to less demanding and safer medical interventions. In cardiovascular procedures interventionalists turn towards catheter-based interventions, treating patients considered unfit for more invasive approaches. A positive outcome is not guaranteed. The risk for calcium dislodgement, tissue damage or even vessel rupture cannot be eliminated when instruments are maneuvered through fragile and diseased vessels. This paper reports on the progress made in terms of catheter design, vessel reconstruction, catheter shape modeling, surgical skill analysis, decision making and control. These efforts are geared towards the development of the necessary technology to autonomously steer catheters through the vasculature, a target of the EU-funded project Cognitive AutonomouS CAtheters operating in Dynamic Environments (CASCADE). Whereas autonomous placement of an aortic valve implant forms the ultimate and concrete goal, the technology of individual building blocks to reachsuch ambitious goal is expected to be much sooner impacting and assisting interventionalists in their daily clinical practice.

  • Journal article
    Constantinescu MAM, Lee S, Navkar NV, Yu W, Al-Rawas S, Abinahed J, Zheng G, Keegan J, Al-Ansari A, Jomaah N, Landreau P, Yang GZet al., 2016,

    Constrained Statistical Modelling of Knee Flexion from Multi-Pose Magnetic Resonance Imaging

    , IEEE Transactions on Medical Imaging, Vol: 35, Pages: 1686-1695, ISSN: 1558-254X

    Reconstruction of the anterior cruciate ligament (ACL) through arthroscopy is one of the most common procedures in orthopaedics. It requires accurate alignment and drilling of the tibial and femoral tunnels through which the ligament graft is attached. Although commercial computer-assisted navigation systems exist to guide the placement of these tunnels, most of them are limited to a fixed pose without due consideration of dynamic factors involved in different knee flexion angles. This paper presents a new model for intraoperative guidance of arthroscopic ACL reconstruction with reduced error particularly in the ligament attachment area. The method uses 3D preoperative data at different flexion angles to build a subject-specific statistical model of knee pose. To circumvent the problem of limited training samples and ensure physically meaningful pose instantiation, homogeneous transformations between different poses and local-deformation finite element modelling are used to enlarge the training set. Subsequently, an anatomical geodesic flexion analysis is performed to extract the subject-specific flexion characteristics. The advantages of the method were also tested by detailed comparison to standard Principal Component Analysis (PCA), nonlinear PCA without training set enlargement, and other state-of-the-art articulated joint modelling methods. The method yielded sub-millimetre accuracy, demonstrating its potential clinical value.

  • Conference paper
    Zhao L, Giannarou S, Lee S, Merrifield R, Yang GZet al., 2016,

    Intra-operative simultaneous catheter and environment modelling for endovascular navigation based on intravascular ultrasound, electromagnetic tracking and pre-operative data

    , The Hamlyn Symposium on Medical Robotics, Publisher: The Hamlyn Symposium on Medical Robotics, Pages: 76-77
  • Conference paper
    Zhou X, Yang GZ, Riga C, Lee Set al., 2016,

    Stent graft shape instantiation for fenestrated endovascular aortic repair

    , The Hamlyn Symposium on Medical Robotics, Publisher: The Hamlyn Symposium on Medical Robotics, Pages: 78-79
  • Journal article
    Lee S, Aguib H, Chapron J, Bahmanyar R, Borghi A, Murphy O, McLeod C, ElGuindy A, Yacoub Met al., 2016,

    Spatial Orientation and Morphology of the Pulmonary Artery: Relevance to Optimising Design and Positioning of a Continuous Pressure Monitoring Device

    , Journal of Cardiovascular Translational Research, Vol: 9, Pages: 239-248, ISSN: 1937-5387

    Personalised treatment of heart disease requires an understanding of the patient-specific characteristics,which can vary over time. A newly developed implantable surface acoustic wave pressure sensor, capable ofcontinuous monitoring of the left ventricle filling pressure, is a novel device for personalised management ofpatients with heart disease. However, a one-size-fits-all approach to device sizing will affect its positioningwithin the pulmonary artery and its relationship to the interrogating device on the chest wall on a patientspecificlevel. In this paper, we analyse the spatial orientation and morphology of the pulmonary artery and itsmain branches in patients who could benefit from the device and normal controls. The results could optimisethe design of the sensor, its stent, and importantly its placement, ensuring long-term monitoring in patientgroups.

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