The Centre has a long history of developing new techniques for medical imaging (particularly in magnetic resonance imaging), transforming them from a primarily diagnostic modality into an interventional and therapeutic platform. This is facilitated by the Centre's strong engineering background in practical imaging and image analysis platform development, as well as advances in minimal access and robotic assisted surgery. Hamlyn has a strong tradition in pursuing basic sciences and theoretical research, with a clear focus on clinical translation.
In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting during surgical intervention, our recent research has also been focussed on novel biophotonics platforms that can be used for real-time tissue characterisation, functional assessment, and intraoperative guidance during minimally invasive surgery. This includes, for example, SMART confocal laser endomicroscopy, time-resolved fluorescence spectroscopy and flexible FLIM catheters.
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At the Hamlyn Centre, we work on a broad range of imaging modalities, particularly in cardiovascular magnetic resonance imaging. These include the development of accurate cardiac function measurement including phase contrast velocity mapping, myocardial perfusion and coronary imaging.
The use of minimally invasive and flexible access surgery has imposed significant challenges on surgical navigation. Our work focuses on combining prior knowledge of the anatomical model with subject specific information derived from pre- and intra-operative imaging for image-guided surgery.
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Surgical Imaging and Vision
At the Hamlyn Centre, we are working towards the development of lightweight, cost-effective, flexible manipulators with minimum footprint in the operative theatre that enhance current surgical workflow as well as new techniques for providing synergistic control between the surgeon and the robot.
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Journal articleHooshmand S, Kargozar S, Ghorbani A, et al., 2020,
Biomedical Waste Management by Using Nanophotocatalysts: The Need for New Options, MATERIALS, Vol: 13
- Author Web Link
- Citations: 12
Journal articleKeshavarz M, Wales DJ, Seichepine F, et al., 2020,
Induced neural stem cell differentiation on a drawn fiber scaffold-toward peripheral nerve regeneration, Biomedical Materials, Vol: 15, ISSN: 1748-6041
To achieve regeneration of long sections of damaged nerves, restoration methods such as direct suturing or autologous grafting can be inefficient. Solutions involving biohybrid implants, where neural stem cells are grown in vitro on an active support before implantation, have attracted attention. Using such an approach, combined with recent advancements in microfabrication technology, the chemical and physical environment of cells can be tailored in order to control their behaviors. Herein, a neural stem cell polycarbonate fiber scaffold, fabricated by 3D printing and thermal drawing, is presented. The combined effect of surface microstructure and chemical functionalization using poly-ʟ-ornithine (PLO) and double-walled carbon nanotubes (DWCNTs) on the biocompatibility of the scaffold, induced differentiation of the neural stem cells (NSCs) and channeling of the neural cells was investigated. Upon treatment of the fiber scaffold with a suspension of DWCNTs in PLO (0.039 gL-1) and without recombinants a high degree of differentiation of NSCs into neuronal cells was confirmed by using nestin, galactocerebroside (GalC) and doublecortin (Dcx) immunoassays. These findings illuminate the potential use of this biohybrid approach for the realization of future nerve regenerative implants.
Journal articleKassanos P, Berthelot M, Kim JA, et al., 2020,
Smart sensing for surgery from tethered devices to wearables and implantables, IEEE Systems Man and Cybernetics Magazine, Vol: 6, Pages: 39-48, ISSN: 2333-942X
Recent developments in wearable electronics have fueled research into new materials, sensors, and microelectronic technologies for the realization of devices that have increased functionality and performance. This is further enhanced by advances in fabr ication methods and printing techniques, stimulating research on implantables and the advancement of existing medical devices. This article provides an overview of new designs, embodiments, fabrication methods, instrumentation, and informatics as well as the challenges in developing and deploying such devices and clinical applications that can benefit from them. The need for and use of these technologies across the perioperative surgical-care pathway are highlighted, along with a vision for the future and how these tools can be adopted by potential end users and health-care systems.
Journal articleGiannarou S, Hacihaliloglu I, 2020,
IJCARS - IPCAI 2020 special issue: 11th conference on information processing for computer-assisted interventions - part 1, International Journal of Computer Assisted Radiology and Surgery, Vol: 15, Pages: 737-738, ISSN: 1861-6410
Journal articleKim JA, Wales D, Thompson A, et al., 2020,
Fiber-optic SERS probes fabricated using two-photon polymerization for rapid detection of bacteria, Advanced Optical Materials, Vol: 8, Pages: 1-12, ISSN: 2195-1071
This study presents a novel fiber-optic surface-enhanced Raman spectroscopy (SERS) probe (SERS-on-a-tip) fabricated using a simple, two-step protocol based on off-the-shelf components and materials, with a high degree of controllability and repeatability. Two-photon polymerization and subsequent metallization was adopted to fabricate a range of SERS arrays on both planar substrates and end-facets of optical fibers. For the SERS-on-a-tip probes, a limit of detection of 10-7 M (Rhodamine 6G) and analytical enhancement factors of up to 1300 were obtained by optimizing the design, geometry and alignment of the SERS arrays on the tip of the optical fiber. Furthermore, strong repeatability and consistency were achieved for the fabricated SERS arrays, demonstrating that the technique may be suitable for large-scale fabrication procedures in the future. Finally, rapid SERS detection of live Escherichia coli cells was demonstrated using integration times in the milliseconds to seconds range. This result indicates strong potential for in vivo diagnostic use, particularly for detection of infections. Moreover, to the best of our knowledge, this represents the first report of detection of live, unlabeled bacteria using a fiber-optic SERS probe.
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