The Centre has a long history of developing new techniques for medical imaging (particularly in magnetic resonance imaging), transforming them from a primarily diagnostic modality into an interventional and therapeutic platform. This is facilitated by the Centre's strong engineering background in practical imaging and image analysis platform development, as well as advances in minimal access and robotic assisted surgery. Hamlyn has a strong tradition in pursuing basic sciences and theoretical research, with a clear focus on clinical translation.

In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting during surgical intervention, our recent research has also been focussed on novel biophotonics platforms that can be used for real-time tissue characterisation, functional assessment, and intraoperative guidance during minimally invasive surgery. This includes, for example, SMART confocal laser endomicroscopy, time-resolved fluorescence spectroscopy and flexible FLIM catheters.

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    Karlas A, Su-Lin Lee, 2015,

    Towards an IVUS-driven system for endovascular navigation

    , Biomedical Imaging (ISBI), 2015 IEEE 12th International Symposium on, Pages: 1324-1327
    Ye M, 2015,

    Method and Apparatus

    , WO/2015/033147
    Constantinescu M, Lee SL, Ernst S, Yang GZet al., 2015,

    Multi-source motion decoupling ablation catheter guidance for electrophysiology procedures

    , 5th International Workshop, STACOM 2014, Held in Conjunction with MICCAI 2014, Publisher: Springer, Pages: 213-220, ISSN: 0302-9743

    Accurate and stable positioning of the ablation catheter tip during the delivery of radiofrequency impulses in cardiac electrophysiology remains a challenge due to the endocardium motion from multiple sources (cardiac cycle and respiration) and inevitable slippage of the catheter tip. This paper presents a novel ablation catheter guidance framework during electrophysiology procedures. Catheter tip electrode position readings from intraoperative electroanatomical data are used to decouple tip motion from different motion sources as part of the pre-ablation mapping. The resulting information is then used to determine if there is relative slippage between the catheter tip and endocardial surface and is shown as a probabilitymap for online decision support of the ablation process. The proposed decomposition method and the slippage assessment were performed on a retrospective cohort of 19 patients treated for ventricular tachycardia (13 cases) or atrial fibrillation (6 cases) and were also validated on artificially generated signals.

    Koutsoumpa C, Simpson R, Keegan J, Firmin D, Yang G-Zet al., 2015,

    Restoration of Phase-Contrast Cardiovascular MRI for the Construction of Cardiac Contractility Atlases

    , 5th International Workshop, (STACOM), Publisher: SPRINGER-VERLAG BERLIN, Pages: 275-283, ISSN: 0302-9743
    Ali K, Brizzi A, Lee S-L, Yang G-Z, Alomainy A, Hao Yet al., 2014,

    Quantitative Analysis of the Subject-Specific On-Body Propagation Channel Based on Statistically Created Models

    , IEEE Antennas and Wireless Propagation Letters, Vol: 14, Pages: 398-401, ISSN: 1548-5757

    This letter presents a quantitative approach to the investigationof subject-specific on-body communication channels.To this aim, propagation at 5.8 GHz has been studied considering50 realistic digital phantoms, statistically generated from a set of 20magnetic resonance (MR) scans. Both line-of-sight (LoS) and nonline-of-sight(NLoS) communication links have been taken into account.Mathematical expressions are proposed reflecting the correlationbetween body dimensions (specifically height and waist) andpath-loss variation. Results show that linear fitting can be extrapolatedbetween path-loss variations and body shape parameters.In-house parallel finite-difference time-domain (PFDTD) numericalmethod has been applied to carry out full-wave simulations onthe 50 digital phantoms.

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