The Centre has a long history of developing new techniques for medical imaging (particularly in magnetic resonance imaging), transforming them from a primarily diagnostic modality into an interventional and therapeutic platform. This is facilitated by the Centre's strong engineering background in practical imaging and image analysis platform development, as well as advances in minimal access and robotic assisted surgery. Hamlyn has a strong tradition in pursuing basic sciences and theoretical research, with a clear focus on clinical translation.

In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting during surgical intervention, our recent research has also been focussed on novel biophotonics platforms that can be used for real-time tissue characterisation, functional assessment, and intraoperative guidance during minimally invasive surgery. This includes, for example, SMART confocal laser endomicroscopy, time-resolved fluorescence spectroscopy and flexible FLIM catheters.


BibTex format

author = {Ye, M and Giannarou, S and Patel, N and Teare, J and Yang, G-Z},
doi = {10.1007/978-3-642-40763-5_9},
pages = {67--74},
publisher = {Springer Berlin Heidelberg},
title = {Pathological Site Retargeting under Tissue Deformation Using Geometrical Association and Tracking},
url = {},

RIS format (EndNote, RefMan)

AB - Recent advances in microscopic detection techniques includefluorescence spectroscopy, fibred confocal microscopy and optical coher-ence tomography. These methods can be integrated with miniaturisedprobes to assist endoscopy, thus enabling diseases to be detected at anearly and pre-invasive stage, forgoing the need for histopathological sam-ples and off-line analysis. Since optical-based biopsy does not leave vis-ible marks after sampling, it is important to track the biopsy sites toenable accurate retargeting and subsequent serial examination. In thispaper, a novel approach is proposed for pathological site retargeting ingastroscopic examinations. The proposed method is based on affine defor-mation modelling with geometrical association combined with cascadedonline learning and tracking. It provides online in vivo retargeting, and is able to track pathological sites in the presence of tissue deformation. It is also robust to partial occlusions and can be applied to a range of imaging probes including confocal laser endomicroscopy.
AU - Ye,M
AU - Giannarou,S
AU - Patel,N
AU - Teare,J
AU - Yang,G-Z
DO - 10.1007/978-3-642-40763-5_9
EP - 74
PB - Springer Berlin Heidelberg
SN - 0302-9743
SP - 67
TI - Pathological Site Retargeting under Tissue Deformation Using Geometrical Association and Tracking
UR -
UR -
ER -