In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting to allow for real-time tissue characterization, functional assessment, and intraoperative guidance, we have an active research programme on biophotonics with specific focus on in situ, in vivo tissue characterization and surgical guidance. Our key research interests include development and application of photonics technology to surgical imaging and surgical robotics, which include the development of imaging catheters for fluorescence lifetime imaging (FLIM), multispectral polarization sensitive laparoscopes with MEMS controlled spectral selection, probe-based endo-microscopes, illumination optics for flexible robotic endoscopes and optical detection of gold nanoparticles and thermal therapy.