A primary motivation of our research is the monitoring of physical, physiological, and biochemical parameters - in any environment and without activity restriction and behaviour modification - through using miniaturised, wireless Body Sensor Networks (BSN). Key research issues that are currently being addressed include novel sensor designs, ultra-low power microprocessor and wireless platforms, energy scavenging, biocompatibility, system integration and miniaturisation, processing-on-node technologies combined with novel ASIC design, autonomic sensor networks and light-weight communication protocols. Our research is aimed at addressing the future needs of life-long health, wellbeing and healthcare, particularly those related to demographic changes associated with an ageing population and patients with chronic illnesses. This research theme is therefore closely aligned with the IGHI’s vision of providing safe, effective and accessible technologies for both developed and developing countries.

Some of our latest works were exhibited at the 2015 Royal Society Summer Science Exhibition.


Citation

BibTex format

@article{Keshavarz:2018:10.1021/acsami.8b10590,
author = {Keshavarz, M and Tan, B and Venkatakrishnan, K},
doi = {10.1021/acsami.8b10590},
journal = {ACS Appl Mater Interfaces},
title = {Label-Free SERS Quantum Semiconductor Probe for Molecular-Level and in Vitro Cellular Detection: A Noble-Metal-Free Methodology.},
url = {http://dx.doi.org/10.1021/acsami.8b10590},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Accurate in vitro molecular-level analysis is an essential step prior to in vivo and clinical application for early diagnosis and cancer treatment. Among the diagnostic techniques, surface-enhanced Raman scattering (SERS) biosensing has shown growing potential due to its noninvasive and real-time characterization of the biomolecules. However, the application of SERS biosensing is mostly limited to the plasmonic noble metals, in the form of either nanoparticles or tips and substrates (fixed probe), on which surface plasmon resonance (SPR) is the prominent enhancement principle. The semiconductor quantum particles have been explored in several optoelectronics applications, but have never been reported to be exploited as a means of surface-enhanced Raman scattering (SERS) for molecular-level and intracellular sensing. Here, we report on the new generation of noble-metal-free SERS probe; Si@SiO2 quantum probe (Si@SiO2 Q-probe) whose affinity to functional groups not only imitates a self-driven labeling attribution that enables charge transfer (CT) as an augmented enhancement principle but also its mobile nature in miniaturized scale facilitates endocytosis for in situ live cell biosensing. Moreover, a significant enhancement factor of 106 of rhodamine 6G (R6G) and 107 of glutathione (GSH) at ∼5 × 10-12 pM concentration has been achieved that is comparable to inherently plasmonic noble metals. Our results showed a capability of the Si@SiO2 Q-probe to unveil the "biochemical fingerprint" of substantial components of mammalian and cancerous cervical cells, which leads to diagnosis of cervical cancer. These unique attributions of the Si@SiO2 Q-probe can provide better insight into cell mutation and malignancy.
AU - Keshavarz,M
AU - Tan,B
AU - Venkatakrishnan,K
DO - 10.1021/acsami.8b10590
PY - 2018///
TI - Label-Free SERS Quantum Semiconductor Probe for Molecular-Level and in Vitro Cellular Detection: A Noble-Metal-Free Methodology.
T2 - ACS Appl Mater Interfaces
UR - http://dx.doi.org/10.1021/acsami.8b10590
UR - https://www.ncbi.nlm.nih.gov/pubmed/30239189
ER -