A primary motivation of our research is the monitoring of physical, physiological, and biochemical parameters - in any environment and without activity restriction and behaviour modification - through using miniaturised, wireless Body Sensor Networks (BSN). Key research issues that are currently being addressed include novel sensor designs, ultra-low power microprocessor and wireless platforms, energy scavenging, biocompatibility, system integration and miniaturisation, processing-on-node technologies combined with novel ASIC design, autonomic sensor networks and light-weight communication protocols. Our research is aimed at addressing the future needs of life-long health, wellbeing and healthcare, particularly those related to demographic changes associated with an ageing population and patients with chronic illnesses. This research theme is therefore closely aligned with the IGHI’s vision of providing safe, effective and accessible technologies for both developed and developing countries.

Some of our latest works were exhibited at the 2015 Royal Society Summer Science Exhibition.


BibTex format

author = {Keshavarz, M and Wales, DJ and Seichepine, F and Abdelaziz, MEMK and Kassanos, P and Li, Q and Temelkuran, B and Shen, H and Yang, G-Z},
doi = {1748-605X/ab8d12},
journal = {Biomedical Materials},
title = {Induced neural stem cell differentiation on a drawn fiber scaffold-toward peripheral nerve regeneration},
url = {http://dx.doi.org/10.1088/1748-605X/ab8d12},
volume = {15},
year = {2020}

RIS format (EndNote, RefMan)

AB - To achieve regeneration of long sections of damaged nerves, restoration methods such as direct suturing or autologous grafting can be inefficient. Solutions involving biohybrid implants, where neural stem cells are grown in vitro on an active support before implantation, have attracted attention. Using such an approach, combined with recent advancements in microfabrication technology, the chemical and physical environment of cells can be tailored in order to control their behaviors. Herein, a neural stem cell polycarbonate fiber scaffold, fabricated by 3D printing and thermal drawing, is presented. The combined effect of surface microstructure and chemical functionalization using poly--ornithine (PLO) and double-walled carbon nanotubes (DWCNTs) on the biocompatibility of the scaffold, induced differentiation of the neural stem cells (NSCs) and channeling of the neural cells was investigated. Upon treatment of the fiber scaffold with a suspension of DWCNTs in PLO (0.039 gL-1) and without recombinants a high degree of differentiation of NSCs into neuronal cells was confirmed by using nestin, galactocerebroside (GalC) and doublecortin (Dcx) immunoassays. These findings illuminate the potential use of this biohybrid approach for the realization of future nerve regenerative implants.
AU - Keshavarz,M
AU - Wales,DJ
AU - Seichepine,F
AU - Abdelaziz,MEMK
AU - Kassanos,P
AU - Li,Q
AU - Temelkuran,B
AU - Shen,H
AU - Yang,G-Z
DO - 1748-605X/ab8d12
PY - 2020///
SN - 1748-6041
TI - Induced neural stem cell differentiation on a drawn fiber scaffold-toward peripheral nerve regeneration
T2 - Biomedical Materials
UR - http://dx.doi.org/10.1088/1748-605X/ab8d12
UR - https://www.ncbi.nlm.nih.gov/pubmed/32330920
UR - https://iopscience.iop.org/article/10.1088/1748-605X/ab8d12
UR - http://hdl.handle.net/10044/1/79007
VL - 15
ER -