A primary motivation of our research is the monitoring of physical, physiological, and biochemical parameters - in any environment and without activity restriction and behaviour modification - through using miniaturised, wireless Body Sensor Networks (BSN). Key research issues that are currently being addressed include novel sensor designs, ultra-low power microprocessor and wireless platforms, energy scavenging, biocompatibility, system integration and miniaturisation, processing-on-node technologies combined with novel ASIC design, autonomic sensor networks and light-weight communication protocols. Our research is aimed at addressing the future needs of life-long health, wellbeing and healthcare, particularly those related to demographic changes associated with an ageing population and patients with chronic illnesses. This research theme is therefore closely aligned with the IGHI’s vision of providing safe, effective and accessible technologies for both developed and developing countries.

Some of our latest works were exhibited at the 2015 Royal Society Summer Science Exhibition.


BibTex format

author = {Constantinescu, MA and Lee, S-L and Ernst, S and Hemakom, A and Mandic, D and Yang, G-Z},
doi = {10.1016/j.media.2018.03.008},
journal = {Medical Image Analysis},
pages = {1--14},
title = {Probabilistic guidance for catheter tip motion in cardiac ablation procedures},
url = {http://dx.doi.org/10.1016/j.media.2018.03.008},
volume = {47},
year = {2018}

RIS format (EndNote, RefMan)

AB - Radiofrequency catheter ablation is one of the commonly available therapeutic methods for patients suffering from cardiac arrhythmias. The prerequisite of successful ablation is sufficient energy delivery at the target site. However, cardiac and respiratory motion, coupled with endocardial irregularities, can cause catheter drift and dispersion of the radiofrequency energy, thus prolonging procedure time, damaging adjacent tissue, and leading to electrical reconnection of temporarily ablated regions. Therefore, positional accuracy and stability of the catheter tip during energy delivery is of great importance for the outcome of the procedure. This paper presents an analytical scheme for assessing catheter tip stability, whereby a sequence of catheter tip motion recorded at sparse locations on the endocardium is decomposed. The spatial sliding component along the endocardial wall is extracted from the recording and maximal slippage and its associated probability are computed at each mapping point. Finally, a global map is generated, allowing the assessment of potential areas that are compromised by tip slippage. The proposed framework was applied to 40 retrospective studies of congenital heart disease patients and further validated on phantom data and simulations. The results show a good correlation with other intraoperative factors, such as catheter tip contact force amplitude and orientation, and with clinically documented anatomical areas of high catheter tip instability.
AU - Constantinescu,MA
AU - Lee,S-L
AU - Ernst,S
AU - Hemakom,A
AU - Mandic,D
AU - Yang,G-Z
DO - 10.1016/j.media.2018.03.008
EP - 14
PY - 2018///
SN - 1361-8415
SP - 1
TI - Probabilistic guidance for catheter tip motion in cardiac ablation procedures
T2 - Medical Image Analysis
UR - http://dx.doi.org/10.1016/j.media.2018.03.008
UR - https://www.ncbi.nlm.nih.gov/pubmed/29653251
UR - http://hdl.handle.net/10044/1/60692
VL - 47
ER -