Clinical & health sciences
Working at the interface between clinician-scientists, health care workers and basic sciences, this pillar will cross programs of research from bench to bedside (translation) and bedside to bench (clinical samples), taking discoveries made in immunology, cell biology and molecular biology, often derived directly from clinical samples, and building on these to inform interventions or drive human clinical trials with vaccines, drugs, novel diagnostics or biosensors.
Our clinical & health sciences champions
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Professor Wendy Barclay
Personal details
Professor Wendy Barclay Action Medical Research Chair Virology, Head of Department of Infectious DiseaseResearch interests
Respiratory viruses, in particular influenza and, most recently, SARS-CoV-2. Studies in the lab aim to understand the molecular and cellular basis of the pathogenesis, host range restrictions and viral transmissibility using genetic techniques to generate recombinant viruses and human airway models.
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Dr Abigail Clements
Research interests
Bacterial pathogenesis, in particular enteric pathogens Shigella, E. coli and emerging nosocomial pathogen Klebsiella pneumoniae . Comparing molecular mechanisms used by these pathogens to establish host infection using a combination of genetic, biochemical, bioinformatic and cell-based techniques.
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Dr Céire Costelloe
Research interests
Addressing key questions in infection-related and antimicrobial-resistant infection (AMR), in particular evaluating interventions targeting AMR using routinely collected clinical data and novel statistical causal inference methods.
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Professor Michael Levin
Research interests
Diagnosis and treatment of a range of childhood infections including meningococcal disease, tuberculosis, bacterial sepsis and Kawasaki disease. Currently leads the EU funded DIAMOND study investigating the application of RNA transcriptomics to improve diagnosis of childhood infection.
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Professor Peter Openshaw
Research interests
How the immune system both protects against viral infection but also causes disease. A long-standing interest in RSV, influenza and, most recently, SARS-CoV-2, with his leadership of the PREPARE EU consortium and ISARIC4C collaborative network focussed on COVID in the UK.
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Dr John Tregoning
Research interests
Developing a range of in vivo and in vitro models of infection and vaccination in early life, including RSV, Influenza, Pseudomonas aeruginosa , Staphylococcus aureus and Acinetobacter baumannii . They are using this approach to develop a broader understanding of respiratory infections and guide the design of vaccines.