Postdoctoral Research Associate in Biochemistry or Structural Biology

Job summary

Applications are invited for Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/).  This post, funded by a highly competitive CRUK Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing biochemical OR structural approaches. The project’s primary objective is to discover 1.) how DNA replication origins are...

Job listing information

  • Reference MED02896
  • Date posted 14 December 2021
  • Closing date 23 January 2022

Job description

Job summary

Applications are invited for Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/).  This post, funded by a highly competitive CRUK Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing biochemical OR structural approaches. The project’s primary objective is to discover 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. You will address how mutations in these processes contribute to genome instability and whether mutations that disrupt these mechanisms are enriched in cancer. The candidate will be able to take advantage of a recently established reconstituted system, which allows us to address these questions for the first time.

Duties and responsibilities

In the laboratory, you will plan and conduct cutting edge DNA replication research. You will have the freedom to steer the research direction, collaborate with team members, supervise students and benefit from dedicated 1:1 and frequent ad-hoc meetings with the group head. Lab meetings, smaller subgroup meetings and related seminars (Biochemistry Club, Work-In-Progress Meetings, Institute-Wide Seminar Series and Happy Hours) provide a great frame work for knowledge exchange and project development. These innovative mechanistic studies will be carried out in a world-leading academic setting, in close collaboration with group members and external collaboration partners.

The current group consists of 12 researchers, including 5 postdocs, 5 PhD students, one lab manager and one technician. The successful candidate will enjoy intensive interactions with group members specialised in cryo-EM, biochemistry, high resolution genomic (ChIP-Exo) and proteomic (ChIP-MS) approaches generating a collaborative and highly productive atmosphere. We are excellent equipped for biochemistry (2 AKTA’s, 4 temperature-controlled shakers, 2 freezer mills, Constant System French Press, Biacore T100), structural EM work (cryo-EM facility with Talos 200kV FEG cryo-EM Falcon 3, Vitrobot IV, Leica GP2, GPU- and data storage-cluster and direct access to a Titan Krios with K3 detector as founding member of the LonCEN consortium) and proteomics (direct access to excellent local proteomics facilities and bioinformatics team).

By joining the group, the candidate will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.

Essential requirements

The candidate should have a PhD in biochemistry, structural biology or neighbouring disciplines, a strong publication record (published or submitted) and very good expertise in troubleshooting. Background in the areas of nucleic acid-protein interactions, cell-cycle, chromatin biology, transcription, kinase regulation, molecular machines, or the broader area of genome stability would be of advantage, but is not necessary.

Further information

The position is fixed-term full time posts for 3 years with the possibility for extension. You will be based at the Hammersmith Campus in a brand-new building, providing an exceptional work environment and in proximity of the Imperial College Faculty of Medicine and the Chemistry Department. The start date is flexible and you should join anytime within the next 12 months.

Should you require any further details on the role please contact: Christian Speck – chris.speck@imperial.ac.uk.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.