Postdoctoral Research Associate in Genomics
Applications are invited for Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/). This post, funded by a highly competitive CRUK Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing genomic approaches. The project’s primary objective is to discover 1.) how DNA replication origins are specified through...
Job listing information
- Reference MED02897
- Date posted 14 December 2021
- Closing date 23 January 2022
Applications are invited for Postdoctoral Research Associate position in the laboratory of Professor Speck at Imperial College London (http://www.specklab.com/). This post, funded by a highly competitive CRUK Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing genomic approaches. The project’s primary objective is to discover 1.) how DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2.) how DNA replication is regulated to allow faithful DNA replication. You will address how mutations in these processes contribute to genome instability and whether mutations that disrupt these mechanisms are enriched in cancer.
Duties and responsibilities
In the laboratory, you will plan and conduct cutting edge DNA replication research. In particular you will be in charge of high-resolution genomics (ChIP, ChIP-seq, ChIP-EXO/Cut&Run, synchronisation of human cells, bioinformatics analysis, RNAi, CRISPR) to address our overall biological questions. You will have the freedom to steer the research direction, collaborate with team members, supervise students and benefit from dedicated 1:1 and frequent ad-hoc meetings with the group head. Lab meetings, smaller subgroup meetings and related seminars (Biochemistry Club, Work-In-Progress Meetings, Institute-Wide Seminar Series and Happy Hours) provide a great frame work for knowledge exchange and project development. These innovative mechanistic studies will be carried out in a world-leading academic setting, in close collaboration with group members and external collaboration partners.
The current group consists of 12 researchers, including 5 postdocs, 5 PhD students, one lab manager and one technician. The successful candidate will enjoy intensive interactions with group members specialised in biochemistry and cryo-EM approaches generating a collaborative and highly productive atmosphere. We are excellent equipped for genomics (direct access to DNA sequencing facility and bioinformatics team) and proteomics (direct access to excellent local proteomics facilities).
By joining the group, the candidate will not only participate in high profile research projects but will also be directly mentored by Professor Speck in grant writing, networking and publishing. Indeed, the scientific framework and the support by Prof. Speck means that the candidates are well placed for a successful transition into independence.
The candidate should have a PhD in genetics, biochemistry or neighbouring disciplines, a strong publication record (published or submitted), very good expertise in troubleshooting and detailed knowledge of ChIP, ChIP-seq (ideally ChIP-EXO/Cut&Tag), library preparation, bioinformatic analysis, siRNA mediated knockdown, CRISPR to generate tagged protein cell lines and the synchronisation of human cells in the cell cycle. Background in the areas of nucleic acid-protein interactions, cell-cycle, chromatin biology, transcription, kinase regulation, molecular machines, or the broader area of genome stability would be of advantage, but is not necessary.
The position is fixed-term full time posts for 3 years with the possibility for extension. You will be based at the Hammersmith Campus in a brand-new building, providing an exceptional work environment and in proximity of the Imperial College Faculty of Medicine and the Chemistry Department. The start date is flexible and you should join anytime within the next 12 months.
Should you require any further details on the role please contact: Christian Speck – firstname.lastname@example.org.
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/
About Imperial College London
Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.
You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.
We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.
It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.
Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are:
In addition to the above, employees are required to observe and comply with all College policies and regulations.
We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender identity, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.
For technical issues when applying online please email email@example.com.
Top 10 Employer for Working Families
Top 10 employer for working families
Race Equality Charter Bronze Award
Race Equality Charter Bronze Award
Athena SWAN Silver Award 2016
We renewed our Silver in the April 2016 submission round. Recognising advancement of gender equality.
Disability Confident leader
Imperial is a Disability Confident leader
Imperial is working in partnership with GIRES to promote respect and provide equal treatment for trans people