The advertised position will be working in Dr Mohamed Shamji’s research group within National Heart and Lung Institute (NHLI), Inflammation Repair and Development, Allergy and Clinical Immunology, Faculty of Medicine. Allergic rhinitis (AR) affects up to 40% of the global population and pose a huge economic and social burden. Whilst AR can be controlled temporarily with symptom-reliever such as anti-histamines and corticosteroids, a small...
Job listing information
- Reference MED03397
- Date posted 20 September 2022
- Closing date 18 October 2022
The advertised position will be working in Dr Mohamed Shamji’s research group within National Heart and Lung Institute (NHLI), Inflammation Repair and Development, Allergy and Clinical Immunology, Faculty of Medicine. Allergic rhinitis (AR) affects up to 40% of the global population and pose a huge economic and social burden. Whilst AR can be controlled temporarily with symptom-reliever such as anti-histamines and corticosteroids, a small proportion of sufferers do not respond to treatment. Allergen-specific immunotherapy (AIT) is indicated in these patients. Despite their efficacy, AIT is associated with long-term treatment regimen which is associated with low patient compliance and occasional severe reactions.
The post-holder will be involved in a very exciting and fast-paced clinical trial study, in collaboration with Revolo Biotherapeutics, to investigate the immunomodulatory properties of a novel peptide that can be used the treatment of allergic rhinitis in AIT. The post-holder will be involved in the collection of clinical samples at multiple timepoints during the clinical trial study and will be involved in performing all relevant immunological and cellular assays to allow assessment of the efficacy of treatment. This will include biobanking of peripheral blood mononuclear cells (PBMCs), basophil activation and histamine release assessment using flow cytometry and in vitro cell culture assays. Flexible attitude towards work is hugely required in this role due to the nature of clinical sample timepoints for the study. The overarching objective is to define the mechanism of action of the novel AIT product and its efficacy.
Duties and responsibilities
- To support Dr Shamji’s research at Imperial college London
- To perform biobanking of PBMCs from whole blood material
- To perform flow cytometry, magnetic cell isolation, cell culture, ELISA, on clinical blood samples obtained from patient sample materials
- To organise and liaise with clinical team to ensure prompt collection of patient sample materials
- To contribute to the supervision and training of undergraduate and master’s students in the lab
- To continually update knowledge and understanding in the field or specialism and develop skills
- To assist with the analysis of data
- To ensure the validity and reliability of data at all times
- To maintain accurate and complete records of clinical samples
- To assist with the writing of reports to research sponsors
- To present findings to colleagues
- To provide advice to other staff and students
- To assist with the publication of findings
- To attend relevant workshops and conferences as necessary
- To develop contacts within the College and the wider community
- To promote the reputation of the Group, the Department and the College
- Hold a Master’s degree (MSc or MRes) in life sciences or equivalent relevant laboratory based experience
- Experience in laboratory-based research
- Practical experience with working with peripheral blood
- Experience in collection, preparation, processing and/or storage of samples
- Experience with data analysis for flow cytometry
- In depth knowledge of allergy and immunology
This is an advert for 2 Full Time and Fixed Term posts for the length of 6 months based at the South Kensington Campus.
About Imperial College London
Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.
You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.
We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.
It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.
Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.
Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are:
In addition to the above, employees are required to observe and comply with all College policies and regulations.
We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.
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