Research Associate - Bioinformatician

Job summary

The successful candidate for this post will assist and support basic, translational research studies and perform bioinformatic analyses related to analysis of big datasets, including GWAS, ChIP-Seq, ATAC-Seq (bulk and single cell), RNA-Seq (bulk and single cell), CITE-Seq, Whole Exome Sequencing, along with integration of electronic medical records. The candidate will need to have evident working experience with script based NGS data analysis...

Job listing information

  • Reference MED03398
  • Date posted 20 September 2022
  • Closing date 18 October 2022

Job description

Job summary

The successful candidate for this post will assist and support basic, translational research studies and perform bioinformatic analyses related to analysis of big datasets, including GWAS, ChIP-Seq, ATAC-Seq (bulk and single cell), RNA-Seq (bulk and single cell), CITE-Seq, Whole Exome Sequencing, along with integration of electronic medical records. The candidate will need to have evident working experience with script based NGS data analysis and bioinformatics.

The post-holder will perform bioinformatic analysis for data integration and single cell data analysis generated using 10x Genomics and other platforms. The post holder will use bioinformatics pipeline/systems well established in the group but will have the freedom to develop novel bioinformatics pipeline to investigate novel hypotheses. Once appointed, the post holder will be involved in developing and driving the project as well as writing up work for presentation and publication.

The post holder will manage relevant academic research and administrative activities. This involves small scale project management, coordinating multiple aspects of work to meet deadlines. The post holder will adapt existing and develop new scientific techniques and experimental protocols, test hypotheses and analyse scientific data from a variety of sources, and review and refine working hypotheses as appropriate. In addition to this, experience with unbiased flow cytometry analysis using visNE, FlowSOM or GigaSOM would also be an advantage. The ideal candidate will be highly communicative with the ability to work independently and as part of a team, excellent communication, organizational and problem-solving skills.

Duties and responsibilities


  • Competency in bioinformatics for data integration and single cell data analysis using 10x genomics.

  • Strong programming skills (i.e. Phyton or R) and competency in command line and use of high-performance computing.

  • Experience and competency in the use of next generation sequencing pipelines in the context of transcriptomics (bulk and single cell) and ATAC-Seq.

  • Experience with unbiased clustering analysis (viSNE, FlowSOM and GigaSOM).

  • To perform statistical and bioinformatic analysis of NGS and other omics data.

  • To conduct data analysis, ensuring the validity and reliability of data at all times.

  • To conduct a specified programme of research and scholarship under the supervision and direction of your Principal Investigator.

  • To engage in appropriate training and professional development opportunities as required by your

  • Principal Investigator, your School or Institute, or the University.

  • To engage in the dissemination of the results of the research in which you are engaged as directed by and with the support of and under the supervision of your Principal Investigator.

Essential requirements


  • Research Associate: Hold a PhD (or equivalent) in Immunology, Genomics Immunology and/or Cancer Biology or a closely related discipline

  • Research Assistant: Near completion of a PhD (or equivalent) in Immunology, Genomics Immunology and/or Cancer Biology or a closely related discipline

  • Strong programming skills (i.e. Phyton or R) and competency in command line and use of high-performance computing.

  • Experience with in-depth experience in the analysis of next-generation sequencing data (with a focus on transcriptomics and epigenetics) and/or analysis of other single cell technologies.

  • Relevant experience in bioinformatics, computational sciences, AI/ML, statistics, physics or mathematics or other area that uses computational modelling would be desirable.

  • Have an active interest in new technology development and advancing the state of the art

  • Experience with statistical and bioinformatic analysis of NGS and other omics data.

Further information

This is a Full Time and Fixed Term role for 1 year initially based at the South Kensington Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 - £41,388 per annum.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see: https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.