Cancer Drug Discovery Biologist (Research Associate)

Job summary

We are seeking an outstanding molecular cell biologist to lead a drug discovery and development team in the group of Professor Ed Tate, sponsored by Myricx Pharma Ltd, a drug discovery spinout founded by Imperial College and the Francis Crick Institute. The position is available full time from January 2020 (or as soon as possible thereafter), for 12 months in the first instance with the potential for extension subject to progress. Applications...

Job listing information

  • Reference NAT00573
  • Date posted 29 October 2019
  • Closing date 26 November 2019

Job description

Job summary

We are seeking an outstanding molecular cell biologist to lead a drug discovery and development team in the group of Professor Ed Tate, sponsored by Myricx Pharma Ltd, a drug discovery spinout founded by Imperial College and the Francis Crick Institute. The position is available full time from January 2020 (or as soon as possible thereafter), for 12 months in the first instance with the potential for extension subject to progress. Applications from candidates with prior biotech/pharma industry experience, or with an interest in joining this sector, are particularly strongly encouraged.

Duties and responsibilities

Currently undisclosed data obtained have revealed exciting and previously unappreciated druggable vulnerabilities in a post-translational modification pathway in a wide range of currently untreatable cancers. We have established proprietary lead molecules targeting this pathway with unprecedented selectivity and potency, and you and your team will work with Myricx on preclinical development of these molecules as novel oncology drugs. Your research will focus on a novel drug target and biomarkers in specific pathways, working in cell models (patient-derived cell lines, co-culture and 3D culture) and advanced animal models of disease, in collaboration with Myricx and experienced contract research organisations (CROs). You will join the Tate group at the state-of-the art £170M Molecular Sciences Research Hub at Imperial’s new White City Campus.

Essential requirements


  • A PhD in molecular cell biology or a closely related field, or an equivalent level of professional qualifications and experience

  • A strong research track record, preferably evidenced by publications or patents

  • Independent capability and creativity in hypothesis generation and experimental design

  • Experience in cell culture and phenotypic/pathway analysis (e.g. microscopy, cytometry, RNA-seq analysis)

  • Ability to set and attain research objectives as part of a multidisciplinary team, and to mentor junior co-workers


Training can be provided in required techniques, but prior experience in at least one of the following areas is highly desirable:



  • Multidisciplinary drug discovery

  • Molecular pharmacology

  • Cancer cell biology and hypothesis-driven drug target validation/analysis

Further information

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant within the salary range £34,397 - £37,486 per annum.

For informal enquiries about the post, please contact Professor Ed Tate: e.tate@imperial.ac.uk

(http://www.imperial.ac.uk/tate-group/).  

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

Committed to equality and valuing diversity.  Imperial College is also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and is working in partnership with GIRES to promote respect for trans people.

The Department of Chemistry proudly holds an Athena SWAN Gold Award and strives to provide a working environment where all our staff feel fully supported to flourish and excel.

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.