Research Associate in Medical Device/Biological Chemistry

Job summary

Surgery utilising cardio-pulmonary bypass causes haemolysis with the release of haemoglobin, haem and iron into the circulation. These products cause inflammation and oxidative stress, which increase the risk of infection, acute kidney injury, pulmonary hypertension and bleeding. You will lead a project under the guidance of Prof Alan Spivey (IC, Chemistry, http://www3.imperial.ac.uk/spiveygroup) Dr Greg Quinlan (IC, NHLI,...

Job listing information

  • Reference NAT00579
  • Date posted 4 November 2019
  • Closing date 9 December 2019

Job description

Job summary

Surgery utilising cardio-pulmonary bypass causes haemolysis with the release of haemoglobin, haem and iron into the circulation. These products cause inflammation and oxidative stress, which increase the risk of infection, acute kidney injury, pulmonary hypertension and bleeding.

You will lead a project under the guidance of Prof Alan Spivey (IC, Chemistry, http://www3.imperial.ac.uk/spiveygroup) Dr Greg Quinlan (IC, NHLI, http://www1.imperial.ac.uk/medicine/people/g.quinlan/), Prof Nathan Davies (UCL, Institute for Liver & Digestive Health, https://iris.ucl.ac.uk/iris/browse/profile?upi=NADAV69) to develop an effective, robust, cost-effective filter that will mitigate the effects of haemolysis by binding extracellular haemoglobin, haem and free iron from human blood.

As a Post-doctoral Research Associate in Medical Device/Biological Chemistry, you will be expected to lead on all aspects of the project including: optimisation of the chemistry of the filter/membrane, proof-of-concept viability testing, prototype filter device development, scientific report and publication writing, in vivo testing and liaising with potential commercial partners.

Duties and responsibilities

You will be expected to develop and test a functioning prototype filter system. Specifically, this will involve both chemical and biochemical/biological skills including:

  • Synthetic organic chemistry skills – to attach commercially available purified plasma proteins and small ligands such as siderophores to various inert matrices via various flexible linker units and develop and asses the relevant coupling chemistries.
  • Analytical chemistry skills – to characterise the resulting filter materials and their effects on standard solutions and blood.
  • Biological material handling skills including aseptic technique - to test the filter in simulated and actual bypass situation and to measure biochemical endpoints under these conditions
  • In vivo studies-to assist with sample collection and to undertake analyses pertinent to the endpoints under investigation.

Essential requirements

We are looking for PhD chemist/biochemist with a strong interest in research with a bio-medical focus who can work independently within an academic research lab environment.

Further information

Further information on the scientific aims of the project are available on request. Informal enquiries are welcomed and should be directed to either Professor Alan Spivey (a.c.spivey@imperial.ac.uk) or Dr Greg Quinlan (g.quinlan@imperial.ac.uk).

For technical issues when applying online please email recruitment@imperial.ac.uk

“Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £34,397 - £37,486 per annum”.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

All Imperial employees are expected to follow the 7 principles of Imperial Expectations: 

  • Champion a positive approach to change and opportunity
  • Communicate regularly and effectively within, and across, teams
  • Consider the thoughts and expectations of others
  • Deliver positive outcomes
  • Encourage inclusive participation and eliminate discrimination
  • Develop and grow skills and expertise
  • Work in a planned and managed way 

In addition to the above, employees are required to observe and comply with all College policies and regulations.

Imperial College is committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment. We are an Athena SWAN Silver award winner, a Stonewall Diversity Champion, a Disability Confident Employer and work in partnership with GIRES to promote respect for trans people.