Research Associate in Biology and Genomics

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute. This...

Job listing information

  • Reference NAT01206
  • Date posted 13 July 2022
  • Closing date 21 August 2022

Job description

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute.

This position is aimed to outstanding biologists wishing to apply their knowledge in genomics and bioinformatics and leverage the novel chemical biology tools available in the Di Antonio group to interrogate DNA structural dynamics in cells, with particular interest in probing epigenetic changes associated with ageing. You will be working in a highly multidisciplinary team and contribute to the research ongoing in the group developing a range of experimental biological approaches to map and visualise DNA G-quadruplex structures in chromatin. Ideally you have some genomics (ChIP-Seq) experience and basic bioinformatics understanding. Candidates keen to apply for their own fellowship will be particularly encouraged to apply. Dr Di Antonio will personally support fellowship and grant applications by the successful candidate during the duration of the 3-years contract. Dr Di Antonio is a BBSRC David Phillips Fellow and a Lister Institute Fellow and can provide substantial support in fellowship applications with a successful track record in this space. 

Duties and responsibilities

You will develop and implement ChIP-Seq experiments tools to map G-quadruplex DNA in C. Elegans chromatin and investigate their accumulation/prevalence during worm ageing. You will also use bioinformatic tools to analyse sequencing data generated and quantify DNA G-quadruplex distribution. You are expected to contribute to the development of these genomics and bionformatic studies, leveraging existing protocols and the knowledge present already in the Di Antonio group.  

As a member of the Di Antonio group, you will also be collaborating with other group members and actively support with student supervision. You will also have the opportunity to present your work at international conferences or webinars and leverage on the recently established group satellite at the Crick Institute to engage with the wider biomedical community for developing the above genomics and bioinformatics tools. This position will be fully based at Imperial College London (White City Campus) but will be in collaboration with Dr John Labbadia (UCL) and occasional visit might be required for sample preparation and collection. You will be also expected to have regular meeting and interactions with the UCL collaborators as well as discussing experimental design and set up.

Essential requirements

Applicants are expected to have a PhD in Biology, Molecular Biology, Biochemistry, Chemical Biology, Chemistry, or a closely related area, or equivalent multidisciplinary experience.

Although the nature of the research is highly multidisciplinary some experience genomics and bioinformatics is highly desirable. Previous experience in Nucleic Acids research both at the chemistry and biochemistry level will beneficial but not essential. The successful candidate must be able to work independently and demonstrate strong organisational and multidisciplinary research collaboration skills. This is an ideal position for experienced scientists seeking to develop innovative Chemical-Biology tools, and with the ambition to establish an independent group in this area. Appropriate support will be provided to successful candidates to develop competitive fellowship applications.

Further information

This is a full time, fixed term position for three years in the first instance. You will be based at the state-of-the-art £170M Molecular Sciences Research Hub at Imperial College White City Campus. Some travel off campus will be required.

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Informal enquiries are welcome and can be made to Dr Marco Di Antonio m.di-antonio@imperial.ac.uk. Please note that this email address is for enquiries only and you should not send your application to this email.

Candidates are required to complete an online application and include a CV and supporting statement. Please indicate in your supporting statement your plan for fellowship applications and your motivation to join the group.

 

 

 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

 

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.