Research Associate in Chemical Biology of Nucleic Acids

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute....

Job listing information

  • Reference NAT01208
  • Date posted 25 July 2022
  • Closing date 21 August 2022

Job description

Job summary

The Di Antonio research group is looking for a talented Research Associate to join the team studying Nucleic Acids structures, working at the interface between Chemistry and Biology. You will work in a multidisciplinary team based in the new Imperial College Molecular Science Research Hub in White City Campus and in close collaboration with the satellite research group that we have recently established at the Francis Crick Institute.

Candidates willing to apply for external fellowships and external funding, wishing to pursue an academic career will be particularly favoured. Dr Di Antonio will personally support fellowship and grant applications by the successful candidate during the duration of the 3-year contract.

Please indicate in your cover letter your motivation to join the team and your plan for fellowship applications, which will be discussed at the interview stage with shortlisted candidates. Dr Di Antonio is a BBSRC David Phillips Fellow and a Lister Institute Fellow and can provide substantial support in fellowship applications with a successful track record in this space. 

This position is aimed to outstanding synthetic chemists wishing to develop novel chemical biology tools to interrogate DNA structural dynamics in cells, with particular interest in developing chemical biology tools to target individual G-quadruplex structures in the genome. Chemical conjugates between CRISPR-Cas9 proteins and G4-ligands will be the main focus of this position. You will be working in a highly multidisciplinary team and contribute to the research ongoing in the group developing a range of experimental approaches at both the chemical and biological level.  

 

 

Duties and responsibilities

The main duty of this position will be a chemical biology platform to target individual G4s in the human genome by developing a chemical conjugate between a G4-ligand and CRISPR-Cas9 tools. You are expected to contribute to the development of these tools from a synthetic chemistry point of view as well as from a more molecular-biology and cell-biology angle, although previous experience in all these areas is not expected. As a member of the Di Antonio group, you will also be collaborating with other group members and support with student supervision. You will also have the opportunity to present your work at international conferences or webinars and leverage on the recently established group satellite at the Crick Institute to engage with the wider biomedical community for application of the platform developed. Dr Di Antonio is particularly keen to fill this position with a motivated candidate wishing to pursue an academic career, offering support for applications to external funding and fellowships.

Essential requirements

Hold a PhD (or equivalent research, industrial or commercial experience)  in Chemistry, Medicinal Chemistry, Chemical Biology, Biochemistry or a closely related discipline

Although the nature of the research is highly multidisciplinary some experience in synthetic organic chemistry is essential to efficiently prepare chemical ligands required. Previous experience in Nucleic Acids research both at the chemistry and biochemistry level will beneficial but not essential. Similarly, experience with molecular biology and/or CRISPR-Cas9 technologies will be considered highly beneficial but not essential. The successful candidate must be able to work independently and demonstrate strong organisational and multidisciplinary research collaboration skills. This is an ideal position for experienced scientists seeking to develop innovative Chemical-Biology tools, and with the ambition to establish an independent group in this area. Appropriate support will be provided to successful candidates to develop competitive fellowship applications.

Further information

This is a full time, fixed term position for three years in the first instance.

You will be based at the state-of-the-art £170M Molecular Sciences Research Hub at Imperial College White City Campus.

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £36,694 - £39,888 per annum.

Informal enquiries are welcome and can be made to Dr Marco Di Antonio m.di-antonio@imperial.ac.uk. Please note that this email address is for enquiries only and you should not send your application to this email.

Candidates are required to complete an online application and include a CV and supporting statement. Please indicate in your supporting statement your plan for fellowship applications and your motivation to join the group, as this will be discussed at interview.

 

 

 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/

 

The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research

Documents

About Imperial College London

Imperial College London is the UK’s only university focussed entirely on science, engineering, medicine and business and we are consistently rated in the top 10 universities in the world.

You will find our main London campus in South Kensington, with our hospital campuses located nearby in West and North London. We also have Silwood Park in Berkshire and state-of-the-art facilities in development at our major new campus in White City.

We work in a multidisciplinary and diverse community for education, research, translation and commercialisation, harnessing science and innovation to tackle the big global challenges our complex world faces.

It’s our mission to achieve enduring excellence in all that we do for the benefit of society – and we are looking for the most talented people to help us get there.

Additional information

Please note that job descriptions cannot be exhaustive, and the post-holder may be required to undertake other duties, which are broadly in line with the above key responsibilities.

Imperial College is committed to equality of opportunity and to eliminating discrimination. All employees are expected to follow the Imperial Values & Behaviours framework. Our values are: 

  • Respect              
  • Collaboration
  • Excellence          
  • Integrity
  • Innovation

In addition to the above, employees are required to observe and comply with all College policies and regulations.

We are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment for all. We therefore encourage candidates to apply irrespective of age, disability, marriage or civil partnership status, pregnancy or maternity, race, religion and belief, gender reassignment, sex, or sexual orientation. We are an Athena SWAN Silver Award winner, a Disability Confident Leader and a Stonewall Diversity Champion.

For technical issues when applying online please email support.jobs@imperial.ac.uk.