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  • Journal article
    Rutherford AW, Seibert M, Metz JG, 1988,

    Characterisation of the low-fluorescent (LF1) mutant of Scenedesmus by EPR

    , BBA - Bioenergetics, Vol: 932, Pages: 171-176, ISSN: 0005-2728

    An EPR study of the low fluorescent mutant, LF1, of the green alga, Scenedesmus obliquus, has been performed and the following results were obtained. (1) Stable photoinduced charge separation occurs at low temperature forming the characteristic EPR signals from Q-AFe2+, the primary semiquinone-iron complex, indicating no major structural modification of the electron acceptor complex in the LF1 mutant. (2) The source of the electron in this reaction at 200 K is a component, probably a chlorophyll molecule, which gives rise to an EPR signal at g ≈ 2.0026 when photooxidized; in the wild type the S2 manganese multiline EPR signal is generated under these conditions. (3) Contrary to a previous report (Biochim. Biophys. Acta 682 (1982) 106-114), Signal II is present in the dark in LF1; however, it exhibits different microwave power saturation characteristics from those of Signal II in the wild type. These results show that the LF1 mutant has a functional reaction centre which lacks the redox active manganese of the O2-evolving enzyme. In addition, as reported previously, cytochrome b-559 is in the low-potential, oxidized form in LF1, while it is largely in the high-potential, reduced form in the wild-type. This effect is thought to be only indirectly related to the 34 kDa to the 36 kDa change in D1 polypeptide size, which is assumed to be responsible for the lack of Mn binding in the LF1 mutant. © 1988.
  • Journal article
    Anderson PM, Barnosky CW, Bartlein PJ, Behling PJ, Brubaker L, Cushing EJ, Dodson J, Dworetsky B, Guetter PJ, Harrison SP, Huntley B, Kutzbach JE, Markgraf V, Marvel R, McGlone MS, Mix A, Moar NT, Morley J, Perrott RA, Peterson GM, Prell WL, Prentice IC, Ritchie JC, Roberts N, Ruddiman WF, Salinger MJ, Spaulding WG, Street-Perrott FA, Thompson RS, Wang PK, Webb T, Winkler MG, Wright HEet al., 1988,

    Climatic changes of the last 18,000 years: Observations and model simulations

    , Science, Vol: 241, Pages: 1043-1052, ISSN: 0036-8075

    Changes in solar radiation arising from changes in the orientation of the earth's axis had pronounced effects on tropical monsoons and mid-latitude climates as well as on ice-sheet configuration during the last 18,000 years. COHMAP (Cooperative Holocene Mapping Project) has assembled a global array of well-dated paleoclimatic data and used general-circulation models to identify and evaluate causes and mechanisms of climatic change. For the northern tropics, particularly in Africa and Asia, data and model results show that the orbitally induced increase in solar radiation in summer 12,000 to 6,000 years ago enhanced the thermal contrast between land and sea and thus produced strong summer monsoons, which raised lake levels in regions that are arid today. In middle to high latitudes the climatic response to both the insolation changes and to the retreating ice sheets led to readjustments in the vegetation in both the Northern and Southern hemispheres. Model results show that the large North American ice sheet split the westerly jet stream into northern and southern branches over North America. An increase in storms associated with the southern branch helps explain high lake levels and increased woodlands in the southwestern United States during full-glacial conditions. Comparisons of paleoclimatic data with the model simulations are important because models provide a theoretical framework for evaluating mechanisms of climatic change, and such comparisons help to evaluate the potential of general circulation models for predicting future climates.
  • Journal article
    DIMARZO V, TIPPINS JR, GALADARI SHI, MORRIS HRet al., 1988,

    NEUROPEPTIDES AND LEUKOTRIENE BIOSYNTHESIS - THE EFFECT OF CALCITONIN, PEPTIDE HISTIDINE VALINE-42, HELODERMIN, NEUROPEPTIDE-Y AND GALANIN

    , NEUROPEPTIDES, Vol: 11, Pages: 169-172, ISSN: 0143-4179
  • Journal article
    TERBRAAK CJF, PRENTICE IC, 1988,

    A THEORY OF GRADIENT ANALYSIS

    , ADVANCES IN ECOLOGICAL RESEARCH, Vol: 18, Pages: 271-317, ISSN: 0065-2504
  • Journal article
    Preiss A, Hartley DA, Artavanis-Tsakonas S, 1988,

    The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila

    , EMBO Journal, Vol: 7, Pages: 3917-3927
  • Journal article
    RK Poole, HD Williams, 1988,

    Formation of a 680 nm absorbing form of the cytochrome bd oxidase complex of Escherichia coli by reaction of hydrogen peroxide with the ferric form

    , FEBS Letters, Vol: 231, Pages: 243-246
  • Journal article
    HD Williams, RK Poole, 1988,

    Cytochromes Acetobacter pasteurianus NCIB 6428: Reaction with oxygen of cytochrome o in cells, membranes, and non-sedimentable subcellular fractions

    , Current Microbiology, Vol: 16, Pages: 277-280
  • Journal article
    CRISANTI A, LAPERA G, LENZI A, GANDINI L, DONDERO F, SPAGNOLI L, DISILVERIO Fet al., 1988,

    STUDY ON AUTO-ANTIGENS OF SPERM CELL-SURFACE - PRELIMINARY DATA ON BIOCHEMICAL-ANALYSIS

    , EOS-RIVISTA DI IMMUNOLOGIA ED IMMUNOFARMACOLOGIA, Vol: 8, Pages: 274-277, ISSN: 0392-6699
  • Book chapter
    Postma PW, Broekhuizen CP, Schuitema A, Vogler AP, Lengeler JWet al., 1988,

    Carbohydrate transport and metabolism in Escherichia coli and Salmonella typhimurium: regulation by the PEP:Carbohydrate Phosphotransferase System. In: Molecular basis of biomembrane transport

    , Molecular basis of biomembrane transport, Editors: Palmieri, Quagliariello, Pages: 43-52
  • Journal article
    Levitan ES, Schofield PR, Burt DR, Rhee LM, Wisden W, Kohler M, Fujita N, Rodriguez HF, Stephenson A, Darlison MG, Barnard EA, Seeburg PHet al., 1988,

    Structural and functional basis for GABAA receptor heterogeneity

    , Nature, Vol: 335, Pages: 76-79, ISSN: 0028-0836

    When gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. Neurotransmitter action at the GABAA receptor is potentiated by both benzodiazepines and barbiturates which are therapeutically useful drugs (reviewed in ref. 1). There is strong evidence that this receptor is heterogeneous. We have previously isolated complementary DNAs encoding an alpha- and a beta-subunit and shown that both are needed for expression of a functional GABAA receptor. We have now isolated cDNAs encoding two additional GABAA receptor alpha-subunits, confirming the heterogeneous nature of the receptor/chloride channel complex and demonstrating a molecular basis for it. These alpha-subunits are differentially expressed within the CNS and produce, when expressed with the beta-subunit in Xenopus oocytes, receptor subtypes which can be distinguished by their apparent sensitivity to GABA. Highly homologous receptor subtypes which differ functionally seem to be a common feature of brain receptors.
  • Journal article
    KAY RR, BERKS M, TRAYNOR D, TAYLOR GW, MASENTO MS, MORRIS HRet al., 1988,

    SIGNALS CONTROLLING CELL-DIFFERENTIATION AND PATTERN-FORMATION IN DICTYOSTELIUM

    , DEVELOPMENTAL GENETICS, Vol: 9, Pages: 579-587, ISSN: 0192-253X
  • Journal article
    Marino G, Pucci P, Malorni A, Morris HRet al., 1988,

    Analysis of post-translational modifications by FAB mass spectrometry.

    , Adv Exp Med Biol, Vol: 231, Pages: 651-657, ISSN: 0065-2598
  • Journal article
    Wisden W, Morris BJ, Darlison MG, Hunt SP, Barnard EAet al., 1988,

    Distinct GABAA receptor alpha subunit mRNAs show differential patterns of expression in bovine brain

    , Neuron, Vol: 1, Pages: 937-947, ISSN: 0896-6273

    Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABAA receptor alpha subunits in bovine brain. In situ hybridization analysis showed that these transcripts differ in distribution and in relative abundance. In frontal cortex the alpha 1 and alpha 2 transcripts are most abundant in layers II-IV, whereas the alpha 3 mRNA is most abundant in layers V and VI. In the hippocampal complex, the alpha transcripts are differentially distributed in the entorhinal cortex and subiculum. The alpha 2 transcript is enriched in the dentate gyrus and CA4/CA3 regions of the hippocampus. In the cerebellum, essentially only the alpha 1 transcript is detectable in granule cells, Purkinje cells, and stellate/basket cells. These results suggest that the different alpha subunits represent components of distinct GABAA receptor subtypes.
  • Journal article
    CAIRNS MT, ALVAREZ J, PANICO M, GIBBS AF, MORRIS HR, CHAPMAN D, BALDWIN SAet al., 1987,

    INVESTIGATION OF THE STRUCTURE AND FUNCTION OF THE HUMAN-ERYTHROCYTE GLUCOSE TRANSPORTER BY PROTEOLYTIC DISSECTION

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 905, Pages: 295-310, ISSN: 0006-3002
  • Journal article
    ZAIDI M, CHAMBERS TJ, DAS REG, MORRIS HR, MACINTYRE Iet al., 1987,

    A DIRECT ACTION OF HUMAN CALCITONIN GENE-RELATED PEPTIDE ON ISOLATED OSTEOCLASTS

    , JOURNAL OF ENDOCRINOLOGY, Vol: 115, Pages: 511-518, ISSN: 0022-0795
  • Journal article
    MCGREGOR MJ, ISLAM SA, STERNBERG MJE, 1987,

    ANALYSIS OF THE RELATIONSHIP BETWEEN SIDE-CHAIN CONFORMATION AND SECONDARY STRUCTURE IN GLOBULAR-PROTEINS

    , JOURNAL OF MOLECULAR BIOLOGY, Vol: 198, Pages: 295-310, ISSN: 0022-2836
  • Journal article
    BARTON GJ, STERNBERG MJE, 1987,

    A STRATEGY FOR THE RAPID MULTIPLE ALIGNMENT OF PROTEIN SEQUENCES - CONFIDENCE LEVELS FROM TERTIARY STRUCTURE COMPARISONS

    , JOURNAL OF MOLECULAR BIOLOGY, Vol: 198, Pages: 327-337, ISSN: 0022-2836
  • Journal article
    BURT A, BELL G, 1987,

    RED QUEEN VERSUS TANGLED BANK MODELS - REPLY

    , NATURE, Vol: 330, Pages: 118-118, ISSN: 0028-0836
  • Journal article
    STERNBERG MJE, HAYES FRF, RUSSELL AJ, THOMAS PG, FERSHT ARet al., 1987,

    PREDICTION OF ELECTROSTATIC EFFECTS OF ENGINEERING OF PROTEIN CHARGES

    , NATURE, Vol: 330, Pages: 86-88, ISSN: 0028-0836
  • Journal article
    LEIS HJ, HOHENESTER E, GLEISPACH H, MALLE E, MAYER Bet al., 1987,

    MEASUREMENT OF PROSTAGLANDINS, THROMBOXANES AND HYDROXY FATTY-ACIDS BY STABLE ISOTOPE-DILUTION GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

    , BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, Vol: 14, Pages: 617-621, ISSN: 0887-6134
  • Journal article
    Hartley DA, Xu TA, Artavanis-Tsakonas S, 1987,

    The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein.

    , EMBO J, Vol: 6, Pages: 3407-3417, ISSN: 0261-4189

    The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting 'neurogenic' genes necessary for the correct segregation of neural from epidermal lineages during embryogenesis. The predicted gene product is implicated in a cell interaction mechanism required to achieve this ectodermal differentiation. We have examined wild-type Notch expression by in situ hybridization and find it to be expressed in more cells than we would have predicted given a sole function in regulating neurogenesis. We conclude from these data that Notch plays a more general role in development. In order to assess the dependence of Notch expression on other neurogenic gene function we have hybridized Notch probes to Enhancer of split mutants which are known to interfere with expression of Notch phenotypes. We intimate that the nature of interaction between these genes is not at the level of transcription. Instead, the DNA sequence of split, which is a missense mutation in the EGF-like extracellular domain of the Notch protein, suggests a direct biochemical interaction between Notch and E(spl) proteins. The similar site of a second point mutation, AxE2, implies that protein interactions also occur between Notch proteins. Finally we discuss the general implications of our findings with a view to the models and mechanisms of Notch action in regulating individual cellular interactions during development.
  • Journal article
    SCHRAG JD, CHENG CHC, PANICO M, MORRIS HR, DEVRIES ALet al., 1987,

    PRIMARY AND SECONDARY STRUCTURE OF ANTIFREEZE PEPTIDES FROM ARCTIC AND ANTARCTIC ZOARCID FISHES

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 915, Pages: 357-370, ISSN: 0006-3002
  • Journal article
    YIANGOU Y, DIMARZO V, SPOKES RA, PANICO M, MORRIS HR, BLOOM SRet al., 1987,

    ISOLATION, CHARACTERIZATION, AND PHARMACOLOGICAL ACTIONS OF PEPTIDE HISTIDINE VALINE 42, A NOVEL PREPROVASOACTIVE INTESTINAL PEPTIDE-DERIVED PEPTIDE

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 262, Pages: 14010-14013, ISSN: 0021-9258
  • Journal article
    ERDJUMENT H, LANE DA, IRELAND H, PANICO M, DIMARZO V, BLENCH I, MORRIS HRet al., 1987,

    FORMATION OF A COVALENT DISULFIDE-LINKED ANTITHROMBIN-ALBUMIN COMPLEX BY AN ANTITHROMBIN VARIANT, ANTITHROMBIN NORTHWICK PARK

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 262, Pages: 13381-13384, ISSN: 0021-9258
  • Journal article
    Di Marzo V, Tippins JR, Morris HR, 1987,

    Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha.

    , Biochem Biophys Res Commun, Vol: 147, Pages: 1213-1218, ISSN: 0006-291X

    The effect of prostaglandins E1 and F1 alpha on peptidoleukotriene biosynthesis/release from rat chopped lung stimulated with platelet activating factor was studied. Prostaglandin E1, known to stimulate adenylate cyclase in airways, inhibited the biosynthesis of leukotrienes C4, D4 and E4 and total peptidoleukotrienes whereas prostaglandin F1 alpha, which has no effect on adenylate cyclase, did not exert any effect on total peptidoleukotriene release, though a small inhibition was found for leukotriene D4. Cyclic AMP itself inhibited peptidoleukotriene release from platelet activating factor-stimulated lung, suggesting that the effect of prostaglandin E1 is mediated by cyclic AMP.
  • Journal article
    DIMARZO V, TIPPINS JR, MORRIS HR, 1987,

    PLATELET ACTIVATING FACTOR-MEDIATED LEUKOTRIENE BIOSYNTHESIS IN RAT LUNGS - EFFECT OF PROSTAGLANDIN-E1 AND PROSTAGLANDIN-F1A

    , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 147, Pages: 1213-1218, ISSN: 0006-291X
  • Journal article
    TAYLOR ME, SUMMERFIELD JA, 1987,

    CARBOHYDRATE-BINDING PROTEINS OF HUMAN-SERUM - ISOLATION OF 2 MANNOSE FUCOSE-SPECIFIC LECTINS

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 915, Pages: 60-67, ISSN: 0006-3002
  • Journal article
    PICK U, GOUNARIS K, BARBER J, 1987,

    DYNAMICS OF PHOTOSYSTEM-II AND ITS LIGHT HARVESTING SYSTEM IN RESPONSE TO LIGHT CHANGES IN THE HALOTOLERANT ALGA DUNALIELLA-SALINA

    , PLANT PHYSIOLOGY, Vol: 85, Pages: 194-198, ISSN: 0032-0889
  • Journal article
    MORRIS HR, TAYLOR GW, MASENTO MS, JERMYN KA, KAY RRet al., 1987,

    CHEMICAL-STRUCTURE OF THE MORPHOGEN DIFFERENTIATION INDUCING FACTOR FROM DICTYOSTELIUM-DISCOIDEUM

    , NATURE, Vol: 328, Pages: 811-814, ISSN: 0028-0836
  • Journal article
    DIMARZO V, TIPPINS JR, MORRIS HR, 1987,

    PAF-MEDIATED LEUKOTRIENE BIOSYNTHESIS IN LUNGS - CONTROL BY THE NEUROPEPTIDERGIC SYSTEM

    , PROSTAGLANDINS, Vol: 34, Pages: 185-185, ISSN: 0090-6980

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