Publications

Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    TURNBULL CGN, CROZIER A, SCHNEIDER G, 1986,

    HPLC-BASED METHODS FOR THE IDENTIFICATION OF GIBBERELLIN CONJUGATES - METABOLISM OF [H-3] GIBBERELLIN-A4 IN SEEDLINGS OF PHASEOLUS-COCCINEUS

    , PHYTOCHEMISTRY, Vol: 25, Pages: 1823-1828, ISSN: 0031-9422
  • Journal article
    BRAIN SD, MACINTYRE I, MORRIS HR, TIPPINS JR, WILLIAMS TJet al., 1985,

    COULD THE POTENT VASODILATOR CALCITONIN GENE-RELATED PEPTIDE BE THE MEDIATOR OF THE FLARE RESPONSE IN HUMAN-SKIN

    , REGULATORY PEPTIDES, Vol: 13, Pages: 92-92, ISSN: 0167-0115
  • Journal article
    Southan C, Thompson E, Panico M, Etienne T, Morris HR, Lane DAet al., 1985,

    Characterization of peptides cleaved by plasmin from the C-terminal polymerization domain of human fibrinogen.

    , J Biol Chem, Vol: 260, Pages: 13095-13101, ISSN: 0021-9258

    The C-terminal region of the fibrinogen gamma chain is known to participate in several functional interactions including fibrin polymerization. This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calcium. In an attempt to characterize the C-terminal polymerization domain we have used three techniques to examine this further degradation of FgD following the addition of EDTA and plasmin. Analysis of the digestion by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a progressive cleavage of the gamma chain to two small remnants. The polymerization-inhibitory activity of the whole digest was studied using acid-solubilized fibrin. A progressive loss of inhibitory activity was associated with gamma chain shortening, reaching greater than a 120-fold reduction at the end of digestion. The cleavage of peptides was followed by reverse-phase high performance liquid chromatography and the release of a characteristic peptide triplet was associated with gamma chain cleavage. Manual sequencing, amino acid analysis, and fast atom bombardment mass spectrometry established the three peptides as gamma 303-356, 357-373, and 374-405. These peptides have sequences in common with those peptides recently reported by other investigators to be potent polymerization inhibitors. However, when a mixture of the three peptides was added in a 200-fold molar excess to polymerizing fibrin, no inhibitory activity could be demonstrated. It is concluded that the C-terminal polymerization domain of fibrinogen may be an extended region which includes the sequence gamma 303-405, when this is contiguous with the remainder of the gamma chain.
  • Journal article
    Rutherford AW, 1985,

    Orientation of EPR signals arising from components in Photosystem II membranes

    , BBA - Bioenergetics, Vol: 807, Pages: 189-201, ISSN: 0005-2728

    EPR signals arising from components in oriented multilayers of Photosystem II (PS II) membranes have been studied and the following results have been obtained. (1) The EPR signals arising from the primary semiquinone-iron complex (Q-AFe) were highly oriented, with features at g = 1.90, g = 1.82 and g = 1.66 showing maxima when the membranes were perpendicular to the magnetic field. (2) The EPR signal, arising from the reduced pheophytin acceptor interacting with Q-AFe, showed an orientation-dependent splitting, ranging from 39 G when the membranes were parallel to the magnetic field to 27 G when the membranes were perpendicular to the magnetic field. (3) The S2 multiline signal associated with the O2-evolving enzyme showed an orientation dependence. This was most marked as position shifts in the low-field wings of the spectrum. These effects indicate that the component is oriented within the membrane and has some magnetically anisotropic character. (4) The component at g {reversed tilde equals} 4, though to be due to an oxidized charge carrier close to S2, showed a slight orientation dependence in its amplitude, but a significant orientation-dependent field-position shift was present, indicating that this is a magnetically anisotropic centre with a fixed geometry in the membrane. (5) Cytochrome b-559 in its oxidized form showed large highly oriented signals. The gz 2.97 feature was maximum when the membranes were oriented parallel to the magnetic field, while the gy 2.22 was maximum when the membrane plane was perpendicular to the magnetic field. This indicates that the haem plane is perpendicular to the plane of the membrane, in agreement with previous reports using chloroplasts. Ageing of the sample brings about a change from low- to high-spin state accompanied by a change in orientation of the haem relative to the membrane (from perpendicular to approximately 45°). (6) Signal II slow, which is present in the dark and which arises from a component which acts a
  • Journal article
    Bateman A, Dell A, Morris HR, 1985,

    Fast atom bombardment mass spectrometry of large peptides: A rapid method for molecular weight analysis

    , Journal of Applied Biochemistry, Vol: 7, Pages: 126-132, ISSN: 0161-7354

    A protocol which permits the molecular weight assignment of polypeptides in the 6000 to 8000-M(r) range has been developed. The procedure, which is based on the technologies of fast atom bombardment ionization and high field magnet mass spectrometry, has been applied to the semiroutine analysis of neurotoxins, including a scorpion toxin of unknown sequence. The type of instrumentation required for these studies is now widely available in mass spectrometry facilities which are readily accessible to the protein chemist. The results reported here indicate that fast atom bombardment mass spectrometry could greatly assist the rapid characterization of protein products of interest to biotechnologists.
  • Journal article
    WERGER MJA, PRENTICE IC, HELSPER HPH, 1985,

    THE EFFECT OF SOD-CUTTING TO DIFFERENT DEPTHS ON CALLUNA HEATHLAND REGENERATION

    , JOURNAL OF ENVIRONMENTAL MANAGEMENT, Vol: 20, Pages: 181-188, ISSN: 0301-4797
  • Journal article
    RUTHERFORD AW, HEATHCOTE P, 1985,

    PRIMARY PHOTOCHEMISTRY IN PHOTOSYSTEM .1.

    , PHOTOSYNTHESIS RESEARCH, Vol: 6, Pages: 295-316, ISSN: 0166-8595
  • Journal article
    ZIMMERMANN JL, RUTHERFORD AW, 1985,

    THE O2-EVOLVING OF PHOTOSYSTEM .2. RECENT ADVANCES

    , PHYSIOLOGIE VEGETALE, Vol: 23, Pages: 425-434, ISSN: 0031-9368
  • Journal article
    RENGER G, RUTHERFORD AW, VOLKER M, 1985,

    EVIDENCE FOR RESISTANCE OF THE MICROENVIRONMENT OF THE PRIMARY PLASTOQUINONE ACCEPTOR (QA-.FE-2+) TO MILD TRYPSINIZATION IN PS-II PARTICLES

    , FEBS LETTERS, Vol: 185, Pages: 243-247, ISSN: 0014-5793
  • Journal article
    RUTHERFORD AW, 1985,

    ORIENTATION OF ELECTRON-PARAMAGNETIC-RES SIGNALS ARISING FROM COMPONENTS IN PHOTOSYSTEM-II MEMBRANES

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 807, Pages: 189-201, ISSN: 0006-3002
  • Journal article
    RUTHERFORD AW, AGALIDIS I, REISSHUSSON F, 1985,

    MANGANESE-QUINONE INTERACTIONS IN THE ELECTRON-ACCEPTOR REGION OF BACTERIAL PHOTOSYNTHETIC REACTION CENTERS

    , FEBS LETTERS, Vol: 182, Pages: 151-157, ISSN: 0014-5793
  • Journal article
    Akam ME, Martinez-Arias A, Weinzierl RO, Wilde CDet al., 1985,

    Function and expression of Ultrabithorax in the Drosophila embryo.

    , Cold Spring Harb. Symp. Quant. Biol., Vol: 50, Pages: 195-200
  • Journal article
    MUECKLER M, CARUSO C, BALDWIN SA, PANICO M, BLENCH I, MORRIS HR, ALLARD WJ, LIENHARD GE, LODISH HFet al., 1985,

    SEQUENCE AND STRUCTURE OF A HUMAN GLUCOSE TRANSPORTER

    , SCIENCE, Vol: 229, Pages: 941-945, ISSN: 0036-8075
  • Journal article
    SOUTHAN C, THOMPSON E, PANICO M, ETIENNE T, MORRIS HR, LANE DAet al., 1985,

    CHARACTERIZATION OF PEPTIDES CLEAVED BY PLASMIN FROM THE C-TERMINAL POLYMERIZATION DOMAIN OF HUMAN-FIBRINOGEN

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 260, Pages: 3095-3101, ISSN: 0021-9258
  • Journal article
    TURNBULL CGN, CROZIER A, SCHWENEN L, GRAEBE JEet al., 1985,

    BIOSYNTHESIS OF GIBBERELLIN-A12-ALDEHYDE, GIBBERELLIN-A12 AND THEIR KAURENOID PRECURSORS FROM [C-14] MEVALONIC ACID IN A CELL-FREE SYSTEM FROM IMMATURE SEED OF PHASEOLUS-COCCINEUS

    , PHYTOCHEMISTRY, Vol: 25, Pages: 97-101, ISSN: 0031-9422
  • Journal article
    MORRIS HR, PUCCI P, 1985,

    A NEW METHOD FOR RAPID ASSIGNMENT OF S-S BRIDGES IN PROTEINS

    , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 126, Pages: 1122-1128, ISSN: 0006-291X
  • Journal article
    VONBOEHMER H, CRISANTI A, KISIELOW P, HAAS Wet al., 1985,

    ABSENCE OF GROWTH BY MOST RECEPTOR-EXPRESSING FETAL THYMOCYTES IN THE PRESENCE OF INTERLEUKIN-2

    , NATURE, Vol: 314, Pages: 539-540, ISSN: 0028-0836
  • Journal article
    MACNAUGHTAN W, SNOOK KA, CASPI E, FRANKS NPet al., 1985,

    AN X-RAY-DIFFRACTION ANALYSIS OF ORIENTED LIPID MULTILAYERS CONTAINING BASIC-PROTEINS

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 818, Pages: 132-148, ISSN: 0006-3002
  • Book chapter
    RK Poole, BS Baines, JAM Hubbard, HD Williamset al., 1985,

    Microbial metabolism of oxygen. The binding and reduction of oxygen by bacterial cytochrome oxidases

    , Microbial Gas Metabolism : Mechanistic, Metabolic and Biotechnological Aspects, Editors: Poole, Dow, London, Publisher: Academic Press, Pages: 31-62
  • Journal article
    PICK U, GOUNARIS K, WEISS M, BARBER Jet al., 1985,

    TIGHTLY BOUND SULFOLIPIDS IN CHLOROPLAST CF0-CF1

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 808, Pages: 415-420, ISSN: 0006-3002
  • Journal article
    STERNBERG MJE, TAYLOR WR, 1985,

    MODELING SRC AND THE EGF RECEPTORS BY COMPUTER-GRAPHICS

    , BRITISH JOURNAL OF CANCER, Vol: 52, Pages: 411-411, ISSN: 0007-0920
  • Journal article
    GIRGIS SI, MACDONALD DWR, STEVENSON JC, BEVIS PJR, LYNCH C, WIMALAWANSA SJ, SELF CH, MORRIS HR, MACINTYRE Iet al., 1985,

    CALCITONIN GENE-RELATED PEPTIDE - POTENT VASODILATOR AND MAJOR PRODUCT OF CALCITONIN GENE

    , LANCET, Vol: 2, Pages: 14-16, ISSN: 0140-6736
  • Journal article
    TURNBULL CGN, HANKE DE, 1985,

    THE CONTROL OF BUD DORMANCY IN POTATO-TUBERS - MEASUREMENT OF THE SEASONAL PATTERN OF CHANGING CONCENTRATIONS OF ZEATIN-CYTOKININS

    , PLANTA, Vol: 165, Pages: 366-376, ISSN: 0032-0935
  • Journal article
    MORRIS HR, 1985,

    NEW STRATEGIES IN BIOMOLECULAR MASS-SPECTROMETRY

    , ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol: 189, Pages: 80-ANYL, ISSN: 0065-7727
  • Journal article
    FRANKS NP, LIEB WR, 1985,

    THE FIREFLY THROWS LIGHT ON ANESTHESIA

    , CHEMISTRY IN BRITAIN, Vol: 21, Pages: 919-921, ISSN: 0009-3106
  • Journal article
    RAWLINGS CJ, TAYLOR WR, NYAKAIRU J, FOX J, STERNBERG MJEet al., 1985,

    REASONING ABOUT PROTEIN TOPOLOGY USING THE LOGIC PROGRAMMING LANGUAGE PROLOG

    , JOURNAL OF MOLECULAR GRAPHICS, Vol: 3, Pages: 151-157, ISSN: 0263-7855
  • Journal article
    BLUNDELL T, STERNBERG MJE, 1985,

    COMPUTER-AIDED-DESIGN IN PROTEIN ENGINEERING

    , TRENDS IN BIOTECHNOLOGY, Vol: 3, Pages: 228-235, ISSN: 0167-7799
  • Journal article
    SINGH AV, MORRIS HR, 1985,

    AN HPLC PUSH-PULL PERFUSION TECHNIQUE FOR INVESTIGATING PEPTIDE METABOLISM

    , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 130, Pages: 37-42, ISSN: 0006-291X
  • Journal article
    THOGERSEN HC, MORRIS HR, RAND KN, GAIT MJet al., 1985,

    LOCATION OF THE ADENYLYLATION SITE IN T4 RNA LIGASE

    , EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 147, Pages: 325-329, ISSN: 0014-2956
  • Journal article
    STRUTHERS AD, BROWN MJ, STEVENSON JC, BEACHAM JL, MORRIS HR, MACINTYRE Iet al., 1985,

    THE CARDIOVASCULAR AND ENDOCRINE EFFECTS OF HUMAN CALCITONIN GENE RELATED PEPTIDE (HCGRP) IN MAN

    , CLINICAL SCIENCE, Vol: 68, Pages: P18-P18, ISSN: 0143-5221

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1200&limit=30&resgrpMemberPubs=true&resgrpMemberPubs=true&page=302&respub-action=search.html Current Millis: 1713492410383 Current Time: Fri Apr 19 03:06:50 BST 2024