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  • Journal article
    TRUEMAN SJ, TURNBULL CGN, 1994,

    EFFECTS OF CROSS-POLLINATION AND FLOWER REMOVAL ON FRUIT-SET IN MACADAMIA

    , ANNALS OF BOTANY, Vol: 73, Pages: 23-32, ISSN: 0305-7364
  • Journal article
    MATHIS P, RUTHERFORD AW, 1994,

    PLANT-PRODUCTION OF OXYGEN

    , RECHERCHE, Vol: 25, Pages: 46-&, ISSN: 0029-5671
  • Journal article
    DELL A, REASON AJ, KHOO KH, PANICO M, MCDOWELL RA, MORRIS HRet al., 1994,

    MASS-SPECTROMETRY OF CARBOHYDRATE-CONTAINING BIOPOLYMERS

    , GUIDE TO TECHNIQUES IN GLYCOBIOLOGY, Vol: 230, Pages: 108-132, ISSN: 0076-6879
    • Cite
    • Citations: 241
  • Book chapter
    Vogler AP, 1994,

    Extinction and the formation of phylogenetic lineages: Diagnosing units of conservation management in the tiger beetle Cicindela dorsalis

    , Molecular ecology and evolution: approaches and applications, Editors: al, Basel, Switzerland, Publisher: Birkhäuser, Pages: 261-273
  • Book chapter
    Barton RA, Purvis A, 1994,

    Primate brains and ecology: looking beneath the surface

    , Current Primatology, volume 1: Ecology & Evolution, Editors: Thierry, Anderson, Roeder JJ, Herrenschmidt, Strasbourg, Publisher: Université Louis Pasteur, Pages: 1-9
  • Journal article
    KELSH R, WEINZIERL ROJ, WHITE RAH, AKAM Met al., 1994,

    HOMEOTIC GENE-EXPRESSION IN THE LOCUST SCHISTOCERCA - AN ANTIBODY THAT DETECTS CONSERVED EPITOPES IN ULTRABITHORAX AND ABDOMINAL-A PROTEINS

    , DEVELOPMENTAL GENETICS, Vol: 15, Pages: 19-31, ISSN: 0192-253X
  • Book chapter
    Drickamer K, 1994,

    Molecular structure of animal lectins

    , Molecular Glycobiology, Editors: Fukuda, Hinsgaul, Nw York, Publisher: Oxford University Press
  • Journal article
    SANTOS GAJ, SHELLEY AJ, CHARALAMBOUS M, LOWRY CA, GRACIO MAA, FORTE JAG, RAYBOULD J, MOLYNEUX D, NHAQUE ATet al., 1994,

    ONCHOCERCIASIS IN GUINEA-BISSAU, WEST-AFRICA

    , PARASITE, Vol: 1, Pages: 6-7, ISSN: 1252-607X
  • Journal article
    Parker KE, Bugeon L, Cuturi MC, Soulillou JPet al., 1994,

    Cloning of cDNA coding for the rat mu heavy chain constant region: differences between rat allotypes.

    , Immunogenetics, Vol: 39, ISSN: 0093-7711
  • Conference paper
    DELL A, PANICO M, MCDOWELL RA, EASTON R, KHOO KH, REASON AJ, SICILIANO R, ZAPPACOSTA F, MORRIS HRet al., 1994,

    APPLICATIONS OF MASS-SPECTROMETRY TO COMPLEX CARBOHYDRATES

    , Alfred Benzon Symposium on Complex Carbohydrates in Drug Research, Publisher: MUNKSGAARD, Pages: 45-59, ISSN: 0105-3639
  • Conference paper
    DAVIS DM, MCLOSKEY D, BIRCH DJS, SWART RM, GELLERT PR, KITTLETY RSet al., 1994,

    FLUORESCENCE STUDIES OF TRYPTOPHAN AND HUMAN SERUM-ALBUMIN (HSA) IN AOT REVERSE MICELLES

    , 4th Biennial Conference on Time-Resolved Laser Spectroscopy in Biochemistry, Publisher: SPIE - INT SOC OPTICAL ENGINEERING, Pages: 331-342
  • Journal article
    King RD, Clark DA, Shirazi J, Sternberg MJet al., 1994,

    Inductive logic programming used to discover topological constraints in protein structures.

    , Proc Int Conf Intell Syst Mol Biol, Vol: 2, Pages: 219-226, ISSN: 1553-0833

    This paper describes the application of the Inductive Logic Programming (ILP) program GOLEM to the discovery of constraints in the packing of beta-sheets in alpha/beta proteins. These constraints (rules) have a role in understanding the protein folding problem. Constraints were learnt for four features of beta-sheet packing: the winding direction of two sequential strands, whether two consecutive strands pack parallel or anti-parallel, whether two strands pack adjacently, and whether a beta-strand is at an edge. Investigation of the learnt constraints revealed interesting patterns, some of which were previously known, others that were novel. Novel features include the discovery: that the relationship between pairs of sequential strands is in general one of decreasing size, and that more sequential pairs of strands wind in the direction out than the direction in. We conclude that machine learning has a useful place in molecular biology as a pattern discovery tool.
  • Conference paper
    DOMENIGHINI M, RAPPUOLI R, PIZZA M, 1994,

    BINDING-SITE STRUCTURE AND MODEL OF THE MECHANISM OF CATALYSIS OF ADP-RIBOSYLATING TOXINS

    , 6th European Workshop on Bacterial Protein Toxins, Publisher: GUSTAV FISCHER VERLAG, Pages: 390-391, ISSN: 0172-5629
  • Conference paper
    RAPPUOLI R, DOMENIGHINI M, MAGAGNOLI C, PIZZA Met al., 1994,

    BACTERIAL ADP-RIBOSYLATING TOXINS - AN UPDATE ON THE STRUCTURE AND FUNCTION OF A FAMILY OF PROBES USEFUL TO DISSECT G-PROTEIN SIGNAL-TRANSDUCTION

    , Serono Symposium on GTPase-Controlled Molecular Machines, Publisher: ARES-SERONO SYMPOSIA PUBLICATIONS, Pages: 95-102
  • Journal article
    Rappuoli R, Pizza M, Podda A, De Magistris MT, Ceccarini C, Nencioni Let al., 1994,

    Development of the new acellular recombinant pertussis vaccine.

    , Arch Inst Pasteur Tunis, Vol: 71, Pages: 557-563, ISSN: 0020-2509
  • Book chapter
    Schoepfer R, Monyer H, Sommer B, Wisden W, Sprengel R, Kuner T, Lomeli H, Herb A, Kohler M, Burnashev N, Gunther G, Ruppersberg P, Seeburg PHet al., 1994,

    Molecular biology of glutamate receptors

    , Progress in Neurobiology, Pages: 353-357

    The ligand-gated receptors for L-glutamate play a central role in acute neuronal degeneration. Recently cDNAs have been isolated for subunits of several glutamate receptor subtypes. By sequence homology all these subunits clearly belong to one large gene family. Several subfamilies exist and match roughly previously pharmacologically and electrophysiologically defined subtypes of glutamate receptors. Currently four genes (GluR A, B, C and D) are known that code for the AMPA subtypes of glutamate receptors. Recombinant expression of wild type and mutated sequences identified a critical residue in the putative TM2 channel-lining segment that controls Ca2+ ion permeability. The arginine (R) found in GluR B subunits at that position renders AMPA channels impermeable for Ca2+ ions, whereas glutamine (Q) containing GluR A, C and D subunits give rise to Ca2+ permeable channels. RNA editing converts the genomically encoded glutamine codon into the arginine codon found in GluR B cDNAs for the Q/R site. NMDA subtypes of glutamate receptors are formed after coexpression of the NR1 cDNA with a cDNA of the NR2 family. Depending on the member of the NR2 family used, NMDA receptors with different kinetical and pharmacological properties are generated. Common to all channels of these NMDA receptors is a high permeability for Ca2+ ions and a voltage dependent block by Mg2+ ions. All currently known NMDA receptor subunits have an asparagine at the Q/R homologous position. We found that this residue is critical for Mg2+ block and Ca2+ permeability of NMDA receptor channels.
  • Book
    Wisden W, Morris BJ, 1994,

    In situ hybridization protocols for the brain

    , Publisher: Academic Pr

    In situ hybridization is an important technique in probing the cellular sites of gene expression within a tissue.
  • Book chapter
    Wisden W, Morris BJ, 1994,

    Studying gene expression in neural tissues using in situ hybridization. The Introduction to In Situ Hybridization Protocols for the Brain - The Biological Techniques Series.

    , In situ hybridization protocols for the brain, Editors: Wisden, Morris, Publisher: Academic Pr, Pages: 1-5

    In situ hybridization is an important technique in probing the cellular sites of gene expression within a tissue.
  • Book chapter
    Wisden W, Morris BJ, 1994,

    In situ hybridization with synthetic oligonucleotide probes.

    , In situ hybridization protocols for the brain, Editors: Wisden, Morris, Publisher: Academic Pr, Pages: 9-34

    In situ hybridization is an important technique in probing the cellular sites of gene expression within a tissue.
  • Conference paper
    VOGLER AP, DESALLE R, 1994,

    MITOCHONDRIAL-DNA EVOLUTION AND THE APPLICATION OF THE PHYLOGENETIC SPECIES CONCEPT IN THE CICINDELA-DORSALIS COMPLEX (COLEOPTERA, CICINDELIDAE)

    , 8th European Carabidologists Meeting/2nd International Symposium of Carabidology, Publisher: KLUWER ACADEMIC PUBL, Pages: 79-85, ISSN: 0080-8954
  • Journal article
    Bahn S, Volk B, Wisden W, 1994,

    Kainate receptor gene expression in the developing rat brain

    , J Neurosci, Vol: 14, Pages: 5525-5547, ISSN: 0270-6474
  • Journal article
    JACKSON RM, STERNBERG MJE, 1993,

    PROTEIN SURFACE-AREA DEFINED

    , NATURE, Vol: 366, Pages: 638-638, ISSN: 0028-0836
  • Journal article
    BRADY HJM, PENNINGTON DJ, MILES CG, DZIERZAK EAet al., 1993,

    CD4 cell surface downregulation in HIV‐1 Nef transgenic mice is a consequence of intracellular sequestration.

    , The EMBO Journal, Vol: 12, Pages: 4923-4932, ISSN: 0261-4189

    The Nef gene product is a regulatory protein of HIV whose biological function is poorly understood. Nef has been thought to have a negative effect on viral replication in vitro but has been shown in studies with SIV to be necessary in the establishment of viraemia in vivo. In vitro studies in various human cell lines have shown that Nef downregulates the expression of cell surface CD4 and thus could have effects on the immune response. We have generated four transgenic mouse lines, with constructs containing two different Nef alleles under the control of CD2 regulatory elements to examine the interaction of Nef with the host immune system in vivo. In adult transgenic mice we have found marked downregulation in the level of CD4 on the surface of double positive thymocytes and a decrease in the number of CD4+ T cells in the thymus. Functional analyses have revealed a decrease in the total activation of transgenic thymocytes by anti‐CD3 epsilon antibody. By specific intracellular staining of T cells in such mice we have found CD4 colocalizing with a Golgi‐specific marker. These results strongly suggest a Nef mediated effect on developing CD4 thymocytes resulting from interference of Nef in the intracellular trafficking or post‐translational modification of CD4.
  • Journal article
    WEINZIERL ROJ, RUPPERT S, DYNLACHT BD, TANESE N, TJIAN Ret al., 1993,

    CLONING AND EXPRESSION OF DROSOPHILA TAF(II)60 AND HUMAN TAF(II)70 REVEAL CONSERVED INTERACTIONS WITH OTHER SUBUNITS OF TFIID

    , EMBO JOURNAL, Vol: 12, Pages: 5303-5309, ISSN: 0261-4189
  • Journal article
    RIEDEL A, KELLNER E, GRODZITZKI D, LIEBL U, HAUSKA G, MULLER A, RUTHERFORD AW, NITSCHKE Wet al., 1993,

    THE [2FE-2S] CENTER OF THE CYTOCHROME BC COMPLEX IN BACILLUS-FIRMUS OF4 IN EPR - AN EXAMPLE OF A MENAQUINOL-OXIDIZING RIESKE CENTER

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 1183, Pages: 263-268, ISSN: 0006-3002
  • Journal article
    King RD, Hirst JD, Sternberg MJE, 1993,

    New approaches to QSAR: Neural networks and machine learning

    , Perspectives in Drug Discovery and Design, Vol: 1, Pages: 279-290, ISSN: 0928-2866

    Neural networks and machine learning are two methods that are increasingly being used to model QSARs. They make few statistical assumptions and are nonlinear and nonparametric. We describe back-propagation from the field of neural networks, and GOLEM from machine learning, and illustrate their learning mechanisms using a simple expository problem. Back-propagation and GOLEM are then compared with multiple linear regression (using the parameters and their squares) on two real drug design problems: the inhibition of Escherichia coli dihydrofolate reductase (DHFR) by pyrimidines and the inhibition of rat/mouse tumour DHFR by triazines. © 1993 ESCOM Science Publishers B.V.
  • Journal article
    Mann DJ, Dombrádi V, Cohen PT, 1993,

    Drosophila protein phosphatase V functionally complements a SIT4 mutant in Saccharomyces cerevisiae and its amino-terminal region can confer this complementation to a heterologous phosphatase catalytic domain.

    , EMBO J, Vol: 12, Pages: 4833-4842, ISSN: 0261-4189

    The sequence of a Drosophila melanogaster cDNA encoding a novel 35 kDa protein serine/threonine phosphatase, termed PPV, is presented. PPV is 40-41% identical to Drosophila PP1, 53% identical to Drosophila PP2A and 63% identical to Saccharomyces cerevisiae SIT4. Complementation studies demonstrated that PPV can functionally rescue a temperature sensitive mutant of SIT4, a protein phosphatase required for the G1 to S transition of the cell cycle. When placed under the SIT4 promoter, PPV cDNA is able to replace the SIT4 gene in S. cerevisiae. The amino-terminal domain of PPV fused to another phosphatase catalytic region (PP1) also rescues the temperature sensitive SIT4 mutant and the SIT4 deletion mutant, implicating this region in binding to regulatory subunits and/or altering specificity. In Drosophila, a substantial transient increase in both PPV mRNA and protein occurs in late syncytial and early cellular blastoderm embryos. At the latter stage PPV is localized to the cytoplasm of cells at the cortex. This increase in PPV correlates with introduction of the G2 phase of the cell cycle, elevated zygotic transcription and cellularization, indicating that PPV may play a role in one or more of these processes.
  • Journal article
    PURVIS A, GARLAND T, 1993,

    POLYTOMIES IN COMPARATIVE ANALYSES OF CONTINUOUS CHARACTERS

    , SYSTEMATIC BIOLOGY, Vol: 42, Pages: 569-575, ISSN: 1063-5157
  • Journal article
    VOGLER AP, KNISLEY CB, GLUECK SB, HILL JM, DESALLE Ret al., 1993,

    USING MOLECULAR AND ECOLOGICAL DATA TO DIAGNOSE ENDANGERED POPULATIONS OF THE PURITAN TIGER BEETLE CICINDELA-PURITANA

    , MOLECULAR ECOLOGY, Vol: 2, Pages: 375-383, ISSN: 0962-1083
    • Cite
    • Citations: 44
  • Journal article
    BESRA GS, MCNEIL MR, KHOO KH, DELL A, MORRIS HR, BRENNAN PJet al., 1993,

    TREHALOSE-CONTAINING LIPOOLIGOSACCHARIDES OF MYCOBACTERIUM-GORDONAE - PRESENCE OF A MONO-O-METHYLTETRA-O-ACYLTREHALOSE CORE AND BRANCHING IN THE OLIGOSACCHARIDE BACKBONE

    , BIOCHEMISTRY, Vol: 32, Pages: 12705-12714, ISSN: 0006-2960

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