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• Journal article
  Adam P, Birks HJB, Huntley B, Prentice ICet al., 1975,

  Phytosociological studies at malham tarn moss and fen, Yorkshire, England

  , Vegetatio, Vol: 30, Pages: 117-132, ISSN: 0042-3106

  During a field course the vegetation of the extensive mire complex on the west side of Malham Tarn was examined. 84 relevés were collected, with 210 taxa in total. This data set has been 'structured' by classical phytosociological techniques. It is suggested that it approaches the maximum size of data-set which can be handled in this way, especially if the data are not all collected by one person. Ordination of the quadrats was carried out but gave little insight into the data despite the use of non-centred as well as centred principal components analysis. Numerical classification of the quadrats using minimumvariance cluster analysis was shown to produce a structure interpretable in ecological terms. A classification of the taxa was carried out by the same method and a 'rearranged' table was drawn up using the results of the two classifications. A relocation technique was applied at an appropriate cluster level but little was felt to be gained from this. The use of 'two-way' minimum-variance cluster analysis for the rapid production of re-arranged tables is recommended for large data-sets. In addition the vegetational units recognised in the data are described and discussed. © 1975 Dr. W. Junk b.v. Publishers.

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  • Citations: 11
• Journal article
  MORRIS HR, 1975,

  PROTEIN SEQUENCE-ANALYSIS AND DISCOVERY OF A NEW AMINO-ACID IN PROTHROMBIN

  , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 3, Pages: 465-467, ISSN: 0300-5127
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  • Citations: 4
• Journal article
  FROMANG DR, SELTZER MB, TOBIAS JA, 1975,

  THORACIC-DUCT CYST CAUSING MEDIASTINAL COMPRESSION AND ACUTE RESPIRATORY INSUFFICIENCY

  , CHEST, Vol: 67, Pages: 725-727, ISSN: 0012-3692
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• Journal article
  MORRIS HR, DELL A, 1975,

  SEQUENCE OF BLOCKED N-TERMINAL PEPTIDE FROM NEUROSPORA GLUTAMATE-DEHYDROGENASE - APPENDIX

  , BIOCHEMICAL JOURNAL, Vol: 149, Pages: 754-755, ISSN: 0264-6021
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  • Citations: 11
• Journal article
  PRENTICE HC, PRENTICE IC, 1975,

  HILL VEGETATION OF NORTH-HOY, ORKNEY

  , NEW PHYTOLOGIST, Vol: 75, Pages: 313-367, ISSN: 0028-646X
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  • Citations: 12
• Journal article
  HUGHES J, SMITH TW, KOSTERLITZ HW, FOTHERGILL LA, MORGAN BA, MORRIS HRet al., 1975,

  IDENTIFICATION OF 2 RELATED PENTAPEPTIDES FROM BRAIN WITH POTENT OPIATE AGONIST ACTIVITY

  , NATURE, Vol: 258, Pages: 577-579, ISSN: 0028-0836
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  • Citations: 3480
• Journal article
  MORRIS HR, THOMPSON MR, DELL A, 1975,

  SYNTHESIS AND PROOF OF STRUCTURE OF NEW AMINO-ACID IN PROTHROMBIN

  , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 62, Pages: 856-861, ISSN: 0006-291X
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  • Citations: 34
• Journal article
  DELL A, WILLIAMS DH, MORRIS HR, SMITH GA, FEENEY J, ROBERTS GCKet al., 1975,

  STRUCTURE REVISION OF ANTIBIOTIC ECHINOMYCIN

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 97, Pages: 2497-2502, ISSN: 0002-7863
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  • Citations: 327
• Journal article
  Morris HR, Williams DH, Midwinter GG, Hartley BSet al., 1974,

  A mass-spectrometric sequence study of the enzyme ribitol dehydrogenase from Klebsiella aerogenes.

  , Biochem J, Vol: 141, Pages: 701-713, ISSN: 0264-6021

  The first detailed results of the application of a low-resolution mixture analysis approach to the sequence analysis of an enzyme, ribitol dehydrogenase, are given. Examples of the interpretation of the spectra of peptide mixtures derived from this protein are described. Evidence for new fragmentation patterns observed is reported, together with an explanation of the generation of ambiguous sequences by use of a low-specificity enzyme, thermolysin. The overall sequencing strategy evolved is assessed.

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• Journal article
  Bridgen J, Morris HR, 1974,

  Use of mass spectrometry and quantitative Edman degradation for the determination of repeating amino-acid sequences.

  , Eur J Biochem, Vol: 44, Pages: 333-334, ISSN: 0014-2956
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• Journal article
  Morris HR, Batley KE, Harding NC, Bjur RA, Dann JG, King RWet al., 1974,

  Dihydrofolate reductase: low-resolution mass-spectrometric analysis of an elastase digest as a sequencing tool.

  , Biochem J, Vol: 137, Pages: 409-411, ISSN: 0264-6021

  An elastase digest of a protein of unknown structure, dihydrofolate reductase, was studied by mass spectrometry. This soluble digest contained a large number of small peptides in different yields, within the ideal molecular-weight range (200-1200) for mixture-analysis mass spectrometry. Sequences of the major component peptides in the digest are reported.

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• Journal article
  DELL A, MORRIS HR, 1974,

  NEW OBSERVATIONS ON FRAGMENTATION PROPERTIES OF PEPTIDES UNDER ELECTRON-IMPACT MASS-SPECTROMETRY

  , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 61, Pages: 1125-1132, ISSN: 0006-291X
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  • Citations: 8
• Journal article
  Morris HR, 1974,

  Peptide sequence determination by mass spectrometry

  , Biochemical Society Transactions, Vol: 2, Pages: 806-808, ISSN: 0300-5127
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  • Citations: 6
• Journal article
  MAGNUSSO S, SOTTRUPJ L, PETERSEN TE, MORRIS HR, DELL Aet al., 1974,

  PRIMARY STRUCTURE OF VITAMIN-K-DEPENDENT PART OF PROTHROMBIN

  , FEBS LETTERS, Vol: 44, Pages: 189-193, ISSN: 0014-5793
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  • Citations: 299
• Journal article
  DELL A, MORRIS HR, WILLIAMS DH, AMBLER RPet al., 1974,

  DETERMINATION OF SEQUENCE INFORMATION IN HOMOLOGOUSLY RELATED PROTEINS BY MASS-SPECTROMETRY

  , BIOMEDICAL MASS SPECTROMETRY, Vol: 1, Pages: 269-273, ISSN: 0306-042X
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  • Citations: 8
• Journal article
  DAICOFF GR, ASLAMI A, TOBIAS JA, MILLER BLet al., 1974,

  MANAGEMENT OF POSTOPERATIVE COMPLETE HEART-BLOCK IN INFANTS AND CHILDREN

  , CHEST, Vol: 66, Pages: 639-641, ISSN: 0012-3692
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• Journal article
  OLSEN GN, BLOCK AJ, TOBIAS JA, 1974,

  PREDICTION OF POSTPNEUMONECTOMY PULMONARY-FUNCTION USING QUANTITATIVE MACROAGGREGATE LUNG-SCANNING

  , CHEST, Vol: 66, Pages: 13-16, ISSN: 0012-3692
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• Conference paper
  TOBIAS JA, LEVY AJ, RAWITSCH RR, 1974,

  COMPLETE EVALUATION FOR PACEMAKER IMPLANTATION

  , Publisher: AMER HEART ASSOC, Pages: 247-247, ISSN: 0009-7322
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• Journal article
  Hunt E, Morris HR, 1973,

  Collagen cross-links. A mass-spectrometric and 1H- and 13C-nuclear-magnetic-resonance study.

  , Biochem J, Vol: 135, Pages: 833-843, ISSN: 0264-6021

  1. The structure of a tetrafunctional cross-link (compound C) isolated from borohydride-reduced cow skin collagen has been determined by the combined use of mass spectrometry and (1)H and (13)C n.m.r. spectroscopy. 2. A new technique, of potentially wide applicability, is described for the mass-spectrometric determination of functional groups. 3. Detailed study of protonation shifts in the (13)C spectrum has allowed an unambiguous assignment of the exact structural relationship of the component parts of the molecule. 4. New interpretations of existing data on this molecule are given.

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• Journal article
  Morris HR, Dickinson RJ, Williams DH, 1973,

  Studies towards the complete sequence determination of proteins by mass spectrometry: derivatisation of methionine, cysteine and arginine containing peptides.

  , Biochem Biophys Res Commun, Vol: 51, Pages: 247-255, ISSN: 0006-291X
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• Journal article
  TOBIAS JA, DAICOFF GR, 1973,

  AORTOGASTRIC AND AORTOILEAL FISTULAS REPAIRED BY DIRECT SUTURE

  , ARCHIVES OF SURGERY, Vol: 107, Pages: 909-911, ISSN: 0004-0010
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• Journal article
  Morris HR, Williams DH, 1972,

  The identification of a mutant peptide of an abnormal haemoglobin by mass spectrometry

  , Journal of the Chemical Society, Chemical Communications, Vol: 0, Pages: 114-116, ISSN: 0022-4936

  A mutant peptide from an abnormal haemoglobin, contaminated by a second peptide, has been sequenced by mass spectrometry; the spectrum of one derivatised mixture allowed the sequences Leu-Leu-Gly-Asn-Val-Leu-Phe and Leu-Leu-Val-Val-Tyr-Pro-Trp to be determined.

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  • Citations: 3
• Journal article
  CZERWINSKI E, 1972,

  Crystallographic study of cytochrome b562 from Escherichia coli*1

  , Journal of Molecular and Cellular Cardiology, Vol: 71, Pages: 819-820, ISSN: 0022-2828
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• Journal article
  Morris HR, 1972,

  Studies towards the complete sequence determination of proteins by mass spectrometry; a rapid procedure for the successful permethylation of histidine containing peptides.

  , FEBS Lett, Vol: 22, Pages: 257-260
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• Journal article
  Morris HR, Williams DH, Ambler RP, 1971,

  Determination of the sequences of protein-derived peptides and peptide mixtures by mass spectrometry.

  , Biochem J, Vol: 125, Pages: 189-201, ISSN: 0264-6021

  Micro-quantities of protein-derived peptides have been converted into N-acetylated permethyl derivatives, and their sequences determined by low-resolution mass spectrometry without prior knowledge of their amino acid compositions or lengths. A new strategy is suggested for the mass spectrometric sequencing of oligopeptides or proteins, involving gel filtration of protein hydrolysates and subsequent sequence analysis of peptide mixtures. Finally, results are given that demonstrate for the first time the use of mass spectrometry for the analysis of a protein-derived peptide mixture, again without prior knowledge of the protein or components within the mixture.

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• Journal article
  Lawson DE, Fraser DR, Kodicek E, Morris HR, Williams DHet al., 1971,

  Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism.

  , Nature, Vol: 230, Pages: 228-230, ISSN: 0028-0836
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• Journal article
  TOBIAS JAY, MERLIS S, 1970,

  LEVODOPA AND SCHIZOPHRENIA

  , JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 211, Pages: 1857-&
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• Journal article
  Lucas F, Barber M, Wolstenholme WA, Geddes AJ, Graham GN, Morris HRet al., 1969,

  Mass-spectrometric determination of the amino acid sequences in peptides isolated from the protein silk fibroin of Bombyx mori.

  , Biochem J, Vol: 114, Pages: 695-702, ISSN: 0264-6021

  Several peptides were isolated from the protein silk fibroin of Bombyx mori by means of ion-exchange chromatography of a chymotryptic digest. The sequences of three of the peptides, Gly-Ala-Gly-Tyr, Gly-Val-Gly-Tyr and Gly-Ala-Gly-Ala-Gly-Ala-Gly-Tyr, were known from previous chemical work, but the sequence of the fourth, Gly-Ala-Gly-Val-Gly-Ala-Gly-Tyr, was previously only partially known. The necessary volatility for mass-spectrometric examination of the peptides was achieved by permethylation of the N-acetyl-peptide methyl ester derivatives. From the mass spectra it was possible to confirm the known sequences and to establish that of the partially known one. In one instance it was possible to deduce from the same mass spectrum the sequence of a main peptide component and that of a small amount of contaminating peptide. These results demonstrate for the first time the use of mass spectrometry in the determination of the amino acid sequences in peptides from a protein hydrolysate.

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• Journal article
  Morris HR, Geddes AJ, Graham GN, 1969,

  Some problems associated with the amino acid-sequence analysis of proteins by mass spectrometry.

  , Biochem J, Vol: 111, ISSN: 0264-6021
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• Journal article
  Cohen F, Sternberg M, 1965,

  [Trials with oxyphenbutazone in pediatrics].

  , Ann Pediatr (Paris), Vol: 12, Pages: 391-395, ISSN: 0066-2097
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