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  • Journal article
    MELTON LD, MCNEIL M, DARVILL AG, ALBERSHEIM P, DELL Aet al., 1986,

    STRUCTURE OF PLANT-CELL WALLS .17. STRUCTURAL CHARACTERIZATION OF OLIGOSACCHARIDES ISOLATED FROM THE PECTIC POLYSACCHARIDE RHAMNOGALACTURONAN-II

    , CARBOHYDRATE RESEARCH, Vol: 146, Pages: 279-305, ISSN: 0008-6215
    • Cite
    • Citations: 51
  • Journal article
    MCNEIL M, DARVILL J, DARVILL AG, ALBERSHEIM P, VANVEEN R, HOOYKAAS P, SCHILPEROORT R, DELL Aet al., 1986,

    HOST SYMBIONT INTERACTIONS .15. THE DISCERNIBLE, STRUCTURAL FEATURES OF THE ACIDIC POLYSACCHARIDES SECRETED BY DIFFERENT RHIZOBIUM SPECIES ARE THE SAME

    , CARBOHYDRATE RESEARCH, Vol: 146, Pages: 307-326, ISSN: 0008-6215
    • Cite
    • Citations: 65
  • Journal article
    ABRAHAM D, DANIEL P, DELL A, OATES J, SIDEBOTHAM R, WINCHESTER Bet al., 1986,

    STRUCTURAL-ANALYSIS OF THE MAJOR URINARY OLIGOSACCHARIDES IN FELINE ALPHA-MANNOSIDOSIS

    , BIOCHEMICAL JOURNAL, Vol: 233, Pages: 899-904, ISSN: 0264-6021
    • Cite
    • Citations: 26
  • Journal article
    RUTHERFORD AW, 1986,

    HOW CLOSE IS THE ANALOGY BETWEEN THE REACTION CENTER OF PHOTOSYSTEM-II AND THAT OF PURPLE BACTERIA

    , BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 14, Pages: 15-17, ISSN: 0300-5127
  • Journal article
    DAVIS KR, DARVILL AG, ALBERSHEIM P, DELL Aet al., 1986,

    HOST-PATHOGEN INTERACTIONS .29. OLIGOGALACTURONIDES RELEASED FROM SODIUM POLYPECTATE BY ENDOPOLYGALACTURONIC ACID LYASE ARE ELICITORS OF PHYTOALEXINS IN SOYBEAN

    , PLANT PHYSIOLOGY, Vol: 80, Pages: 568-577, ISSN: 0032-0889
    • Cite
    • Citations: 141
  • Journal article
    GREENWALD SE, LEVER MJ, MACINTYRE I, MORRIS HR, TIPPINS JRet al., 1986,

    THE EFFECT OF HUMAN CALCITONIN GENE-RELATED PEPTIDE (CGRP) ON THE PIG CORONARY CIRCULATION

    , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 371, Pages: P67-P67, ISSN: 0022-3751
  • Journal article
    HOLLAND EC, DRICKAMER K, 1986,

    SIGNAL RECOGNITION PARTICLE MEDIATES THE INSERTION OF A TRANSMEMBRANE PROTEIN WHICH HAS A CYTOPLASMIC NH2 TERMINUS

    , JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 261, Pages: 1286-1292
    • Cite
    • Citations: 48
  • Journal article
    ELLIOTT JR, HAYDON DA, 1986,

    MAPPING OF GENERAL ANESTHETIC TARGET SITES

    , NATURE, Vol: 319, Pages: 77-78, ISSN: 0028-0836
  • Journal article
    Prentice IC, Webb T, 1986,

    Pollen percentages, tree abundances and the Fagerlind effect

    , Journal of Quaternary Science, Vol: 1, Pages: 35-43, ISSN: 0267-8179

    Pollen diagrams traditionally are read as if pollen percentages were linearly related to relative tree abundances, although the slopes and intercepts of these relationships are accepted to differ among taxa. Corresponding map patterns of modern pollen and tree percentages support this assumption of linearity, which also underlies the use of linear regression on percentage data for pollen‐tree calibration. Fagerlind, however, showed that the theoretical relationship need not be linear and may be confounded by interdependencies among taxa. Regressions and scatter plots of modern pollen and tree percentages are here compared with results of extended R‐value (ERV) models, which correct for the ‘Fagerlind effect’. Three data sets from Wisconsin and Michigan, USA illustrate that regression coefficients provide a first approximation to their ERV equivalents, but scatter plots derived from the ERV analyses show reduced scatter about linearised relationships. Copyright © 1986 John Wiley & Sons, Ltd
  • Journal article
    BARTLEIN PJ, PRENTICE IC, WEBB T, 1986,

    CLIMATIC RESPONSE SURFACES FROM POLLEN DATA FOR SOME EASTERN NORTH-AMERICAN TAXA

    , JOURNAL OF BIOGEOGRAPHY, Vol: 13, Pages: 35-57, ISSN: 0305-0270
  • Journal article
    POST MJD, SHELDON JJ, HENSLEY GT, SOILA K, TOBIAS JA, CHAN JC, QUENCER RM, MOSKOWITZ LBet al., 1986,

    CENTRAL-NERVOUS-SYSTEM DISEASE IN ACQUIRED-IMMUNODEFICIENCY-SYNDROME - PROSPECTIVE CORRELATION USING CT, MR IMAGING, AND PATHOLOGICAL-STUDIES

    , RADIOLOGY, Vol: 158, Pages: 141-148, ISSN: 0033-8419
  • Conference paper
    TOBIAS JA, CAIN JR, SOILA KP, SHELDON JPet al., 1986,

    USEFULNESS OF MAGNETIC-RESONANCE-IMAGING (MRI) IN THE DIAGNOSIS OF RENAL-VEIN THROMBOSIS (RVT)

    , Publisher: ELSEVIER SCIENCE INC, Pages: 206-206, ISSN: 0085-2538
  • Journal article
    RUTHERFORD AW, ACKER S, 1986,

    ORIENTATION OF THE PRIMARY DONOR IN ISOLATED PHOTOSYSTEM-II REACTION CENTERS STUDIED BY ELECTRON-PARAMAGNETIC RESONANCE

    , BIOPHYSICAL JOURNAL, Vol: 49, Pages: 101-102, ISSN: 0006-3495
  • Journal article
    BEVIS PJR, LYNCH C, HILLYARD CJ, AZRIA M, ATTINGER M, MORRIS HR, MACINTYRE Iet al., 1986,

    THE PLASMA-CALCIUM MODULATING EFFECTS OF CALCITONIN GENE-RELATED PEPTIDE

    , BONE, Vol: 7, Pages: 149-149, ISSN: 8756-3282
  • Journal article
    TURNBULL CGN, CROZIER A, SCHNEIDER G, 1986,

    HPLC-BASED METHODS FOR THE IDENTIFICATION OF GIBBERELLIN CONJUGATES - METABOLISM OF [H-3] GIBBERELLIN-A4 IN SEEDLINGS OF PHASEOLUS-COCCINEUS

    , PHYTOCHEMISTRY, Vol: 25, Pages: 1823-1828, ISSN: 0031-9422
    • Cite
    • Citations: 26
  • Journal article
    FRANKS NP, LIEB WR, 1986,

    THE PHARMACOLOGY OF SIMPLE MOLECULES

    , ARCHIVES OF TOXICOLOGY, Pages: 27-37, ISSN: 0340-5761
  • Journal article
    Franks NP, Lieb WR, 1986,

    The pharmacology of simple molecules.

    , Arch Toxicol Suppl, Vol: 9, Pages: 27-37, ISSN: 0171-9750

    The biological effects of simple molecules have traditionally been ascribed to their actions on the lipid portions of biological membranes. However, at the low concentrations of these molecules which induce general anaesthesia or have acute toxic effects in animals, changes in lipid bilayer properties are so small that they are unlikely to be relevant biologically. On the other hand, these molecules do inhibit the activity of a pure lipid-free protein, with ED50 concentrations which are essentially identical to the biological ED50 and LD50 concentrations. Moreover, the well-known but puzzling cutoffs in potencies in homologous series of compounds are also found with this enzyme. The accumulating evidence now suggests that the pharmacological effects of low concentrations of relatively inert agents are best explained in terms of their direct binding to amphiphilic pockets of circumscribed dimensions on proteins.
  • Journal article
    RAWLINGS CJ, TAYLOR WR, NYAKAIRU J, FOX J, STERNBERG MJEet al., 1986,

    USING PROLOG TO REPRESENT AND REASON ABOUT PROTEIN-STRUCTURE

    , LECTURE NOTES IN COMPUTER SCIENCE, Vol: 225, Pages: 536-543, ISSN: 0302-9743
  • Journal article
    BRAIN SD, MACINTYRE I, TIPPINS JR, MORRIS HR, WILLIAMS TJet al., 1986,

    THE VASODILATOR ACTIVITY OF HUMAN ALPHA-CALCITONIN GENE-RELATED PEPTIDE AND RELATED STRUCTURES

    , ACTA PHARMACOLOGICA ET TOXICOLOGICA, Vol: 59, Pages: 147-147, ISSN: 0001-6683
  • Book chapter
    Koufopanou V, 1986,

    The cost of reproduction

    , Oxford Surveys in Evolutionary Biology Vol. 3
  • Journal article
    JANSSON PE, LONNGREN J, WIDMALM G, LEONTEIN K, SLETTENGREN K, SVENSON SB, WRANGSELL G, DELL A, TILLER PRet al., 1985,

    STRUCTURAL STUDIES OF THE O-ANTIGEN POLYSACCHARIDES OF KLEBSIELLA O5 AND ESCHERICHIA-COLI O8

    , CARBOHYDRATE RESEARCH, Vol: 145, Pages: 59-66, ISSN: 0008-6215
    • Cite
    • Citations: 88
  • Journal article
    BRAIN SD, MACINTYRE I, MORRIS HR, TIPPINS JR, WILLIAMS TJet al., 1985,

    COULD THE POTENT VASODILATOR CALCITONIN GENE-RELATED PEPTIDE BE THE MEDIATOR OF THE FLARE RESPONSE IN HUMAN-SKIN

    , REGULATORY PEPTIDES, Vol: 13, Pages: 92-92, ISSN: 0167-0115
  • Journal article
    Southan C, Thompson E, Panico M, Etienne T, Morris HR, Lane DAet al., 1985,

    Characterization of peptides cleaved by plasmin from the C-terminal polymerization domain of human fibrinogen.

    , J Biol Chem, Vol: 260, Pages: 13095-13101, ISSN: 0021-9258

    The C-terminal region of the fibrinogen gamma chain is known to participate in several functional interactions including fibrin polymerization. This part of the molecule is retained on the gamma chain of fragment D (FgD) when fibrinogen is digested by plasmin in the presence of calcium to produce the fragment D-fragment E (FgD X FgE) complex but is lost if FgD is prepared in the absence of calcium. In an attempt to characterize the C-terminal polymerization domain we have used three techniques to examine this further degradation of FgD following the addition of EDTA and plasmin. Analysis of the digestion by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed a progressive cleavage of the gamma chain to two small remnants. The polymerization-inhibitory activity of the whole digest was studied using acid-solubilized fibrin. A progressive loss of inhibitory activity was associated with gamma chain shortening, reaching greater than a 120-fold reduction at the end of digestion. The cleavage of peptides was followed by reverse-phase high performance liquid chromatography and the release of a characteristic peptide triplet was associated with gamma chain cleavage. Manual sequencing, amino acid analysis, and fast atom bombardment mass spectrometry established the three peptides as gamma 303-356, 357-373, and 374-405. These peptides have sequences in common with those peptides recently reported by other investigators to be potent polymerization inhibitors. However, when a mixture of the three peptides was added in a 200-fold molar excess to polymerizing fibrin, no inhibitory activity could be demonstrated. It is concluded that the C-terminal polymerization domain of fibrinogen may be an extended region which includes the sequence gamma 303-405, when this is contiguous with the remainder of the gamma chain.
  • Journal article
    Fukuda M, Bothner B, Ramsamooj P, Dell A, Tiller PR, Varki A, Klock JCet al., 1985,

    Structures of sialylated fucosyl polylactosaminoglycans isolated from chronic myelogenous leukemia cells.

    , J Biol Chem, Vol: 260, Pages: 12957-12967, ISSN: 0021-9258

    Polylactosaminoglycans were isolated from human chronic myelogenous leukemia cells and their structures were elucidated. The lactosaminoglycan saccharides were isolated by hydrazinolysis and fractionated by QAE-Sephadex. The structures of fractionated oligosaccharides were analyzed by fast atom bombardment-mass spectrometry and methylation before and after treatment with specific exoglycosidases, such as alpha 2----3 specific neuraminidase. Based on these experiments, the structures of sialyl polylactosaminoglycans of chronic myelogenous leukemia cells were found to contain the following unique structure which is absent in normal mature granulocytes: (formula; see text) In addition to this, chronic myelogenous leukemia polylactosaminoglycans can be distinguished from normal granulocyte polylactosaminoglycans by the following characteristics. Leukemic polylactosaminoglycans are (a) shorter, (b) more highly sialylated and contain fully sialylated, tetrasialosyl polylactosaminoglycans, (c) are less fucosylated at C-3 of N-acetylglucosamine of polylactosaminyl side chains, and (d) contain a significant amount of sialyl Lex, NeuNAc alpha 2----3Gal beta 1----4(Fuc alpha 1----3)GlcNAc beta 1----3, structure. These results indicate that chronic myelogenous leukemia cells express unique polylactosaminoglycan structures which are distinct from normal mature granulocytes.
  • Journal article
    Rutherford AW, 1985,

    Orientation of EPR signals arising from components in Photosystem II membranes

    , Bba Bioenergetics, Vol: 807, Pages: 189-201, ISSN: 0005-2728

    EPR signals arising from components in oriented multilayers of Photosystem II (PS II) membranes have been studied and the following results have been obtained. (1) The EPR signals arising from the primary semiquinone-iron complex (Q<sup>-</sup><inf>A</inf>Fe) were highly oriented, with features at g = 1.90, g = 1.82 and g = 1.66 showing maxima when the membranes were perpendicular to the magnetic field. (2) The EPR signal, arising from the reduced pheophytin acceptor interacting with Q<sup>-</sup><inf>A</inf>Fe, showed an orientation-dependent splitting, ranging from 39 G when the membranes were parallel to the magnetic field to 27 G when the membranes were perpendicular to the magnetic field. (3) The S<inf>2</inf> multiline signal associated with the O<inf>2</inf>-evolving enzyme showed an orientation dependence. This was most marked as position shifts in the low-field wings of the spectrum. These effects indicate that the component is oriented within the membrane and has some magnetically anisotropic character. (4) The component at g {reversed tilde equals} 4, though to be due to an oxidized charge carrier close to S<inf>2</inf>, showed a slight orientation dependence in its amplitude, but a significant orientation-dependent field-position shift was present, indicating that this is a magnetically anisotropic centre with a fixed geometry in the membrane. (5) Cytochrome b-559 in its oxidized form showed large highly oriented signals. The g<inf>z</inf> 2.97 feature was maximum when the membranes were oriented parallel to the magnetic field, while the g<inf>y</inf> 2.22 was maximum when the membrane plane was perpendicular to the magnetic field. This indicates that the haem plane is perpendicular to the plane of the membrane, in agreement with previous reports using chloroplasts. Ageing of the sample brings about a change from low- to high-spin state accompanied
  • Journal article
    Bateman A, Dell A, Morris HR, 1985,

    Fast atom bombardment mass spectrometry of large peptides: A rapid method for molecular weight analysis

    , Journal of Applied Biochemistry, Vol: 7, Pages: 126-132, ISSN: 0161-7354

    A protocol which permits the molecular weight assignment of polypeptides in the 6000 to 8000-M(r) range has been developed. The procedure, which is based on the technologies of fast atom bombardment ionization and high field magnet mass spectrometry, has been applied to the semiroutine analysis of neurotoxins, including a scorpion toxin of unknown sequence. The type of instrumentation required for these studies is now widely available in mass spectrometry facilities which are readily accessible to the protein chemist. The results reported here indicate that fast atom bombardment mass spectrometry could greatly assist the rapid characterization of protein products of interest to biotechnologists.
  • Journal article
    RUTHERFORD AW, HEATHCOTE P, 1985,

    PRIMARY PHOTOCHEMISTRY IN PHOTOSYSTEM .1.

    , PHOTOSYNTHESIS RESEARCH, Vol: 6, Pages: 295-316, ISSN: 0166-8595
    • Cite
    • Citations: 114
  • Journal article
    ZIMMERMANN JL, RUTHERFORD AW, 1985,

    THE O2-EVOLVING OF PHOTOSYSTEM .2. RECENT ADVANCES

    , PHYSIOLOGIE VEGETALE, Vol: 23, Pages: 425-434, ISSN: 0031-9368
    • Cite
    • Citations: 18
  • Journal article
    RENGER G, RUTHERFORD AW, VOLKER M, 1985,

    EVIDENCE FOR RESISTANCE OF THE MICROENVIRONMENT OF THE PRIMARY PLASTOQUINONE ACCEPTOR (QA-.FE-2+) TO MILD TRYPSINIZATION IN PS-II PARTICLES

    , FEBS LETTERS, Vol: 185, Pages: 243-247, ISSN: 0014-5793
  • Journal article
    RUTHERFORD AW, 1985,

    ORIENTATION OF ELECTRON-PARAMAGNETIC-RES SIGNALS ARISING FROM COMPONENTS IN PHOTOSYSTEM-II MEMBRANES

    , BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 807, Pages: 189-201, ISSN: 0006-3002
    • Cite
    • Citations: 145

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