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• Journal article
  MORRIS HR, 1980,

  BIOMOLECULAR STRUCTURE DETERMINATION BY MASS-SPECTROMETRY

  , NATURE, Vol: 286, Pages: 447-452, ISSN: 0028-0836
  • Cite
  • Citations: 41
• Journal article
  DELL A, MORRIS HR, HECHT SM, LEVIN MDet al., 1980,

  CHARACTERIZATION OF GUANIDINO-CONTAINING ANTIBIOTICS - FIELD DESORPTION MASS-SPECTROMETRY OF BLEOMYCIN-B2 AND PHLEOMYCIN-D1 AND PHLEOMYCIN-E

  , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol: 97, Pages: 987-994, ISSN: 0006-291X
  • Author Web Link
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  • Citations: 15
• Journal article
  Piper PJ, Samhoun MN, Tippins JR, Morris HR, Taylor GWet al., 1980,

  Slow-reacting substances and their structural elucidation.

  , Ciba Found Symp, Vol: 78, Pages: 203-215, ISSN: 0300-5208

  For more than forty years since their discovery, the structure of a group of closely related materials known collectively as slow-reacting substances has been unknown. These substances are released from a variety of tissues in response to immunological or non-immunological stimulation. A slow-reacting substance is believed to be implicated in hypersensitivity reactions such as asthma; in order to fully understand its bronchoconstrictor role, the structural elucidation of these materials has been a necessary (albeit difficult) task. Studies on both immunologically generated slow-reacting substance of anaphylaxis (SRS-A) and other slow-reacting substances (SRSs) have indicated a precursor role for arachidonic acid in their biosynthesis; this, coupled with enzymic and chemical activity destruction data, gave an insight into the structure of these moieties. In order to define the structure of these materials homogeneous SRS-A was required; a purification scheme was developed relying on the high resolution separative capability of reverse-phase high pressure liquid chromatography, resulting in extensively purified SRS-A. It was then possible to demonstrate that SRS-A possessed a characteristic ultraviolet spectrum, allowing us for the first time to define a major structural moiety in the molecule (conjugated triene). To complement studies on, and to act as a model for the more pathologically relevant SRS-A, a slow-reacting substance was produced from rat basophilic leukaemia (RBL-1) cells. The structure of this biologically active species has been determined by mass spectrometric examination of the intact molecule as a derivative, together with analytical protein chemical studies, and shown to be the novel peptidolipid 5-hydroxy-6-cysteinylglycinyl-7,9,11,14-eicosatetraenoic acid.

  • Abstract
  • Author Web Link
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• Journal article
  MORRIS HR, TAYLOR GW, PIPER PJ, TIPPINS JRet al., 1980,

  STRUCTURE OF SLOW-REACTING SUBSTANCE OF ANAPHYLAXIS FROM GUINEA-PIG LUNG

  , NATURE, Vol: 285, Pages: 104-106, ISSN: 0028-0836
  • Author Web Link
  • Cite
  • Citations: 451
• Journal article
  COHEN FE, STERNBERG MJE, TAYLOR WR, 1980,

  ANALYSIS AND PREDICTION OF PROTEIN BETA-SHEET STRUCTURES BY A COMBINATORIAL APPROACH

  , NATURE, Vol: 285, Pages: 378-382, ISSN: 0028-0836
  • Cite
  • Citations: 117
• Journal article
  COHEN FE, STERNBERG MJE, 1980,

  ON THE PREDICTION OF PROTEIN-STRUCTURE - THE SIGNIFICANCE OF THE ROOT-MEAN-SQUARE DEVIATION

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 138, Pages: 321-333, ISSN: 0022-2836
  • Author Web Link
  • Cite
  • Citations: 159
• Journal article
  Drickamer K, 1980,

  Arrangement of the red cell anion transport protein in the red cell membrane: investigation by chemical labeling methods.

  , Ann N Y Acad Sci, Vol: 341, Pages: 419-432, ISSN: 0077-8923
  • Author Web Link
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• Journal article
  MORRIS HR, PIPER PJ, SAMHOUN MN, TAYLOR GW, TIPPINS JRet al., 1980,

  STRUCTURE OF SLOW-REACTING SUBSTANCES

  , BRITISH JOURNAL OF PHARMACOLOGY, Vol: 70, Pages: P118-P119, ISSN: 0007-1188
  • Author Web Link
  • Cite
• Journal article
  FRANKS NP, LIEB WR, 1980,

  RAPID MOVEMENT OF MOLECULES ACROSS MEMBRANES - MEASUREMENT OF THE PERMEABILITY COEFFICIENT OF WATER USING NEUTRON-DIFFRACTION

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 141, Pages: 43-61, ISSN: 0022-2836
  • Author Web Link
  • Cite
  • Citations: 8
• Journal article
  PRENTICE IC, 1980,

  MULTIDIMENSIONAL-SCALING AS A RESEARCH TOOL IN QUATERNARY PALYNOLOGY - A REVIEW OF THEORY AND METHODS

  , REVIEW OF PALAEOBOTANY AND PALYNOLOGY, Vol: 31, Pages: 71-104, ISSN: 0034-6667
  • Author Web Link
  • Cite
  • Citations: 353
• Journal article
  PRENTICE IC, 1980,

  VEGETATION ANALYSIS AND ORDER INVARIANT GRADIENT MODELS

  , VEGETATIO, Vol: 42, Pages: 27-34, ISSN: 0042-3106
  • Author Web Link
  • Cite
  • Citations: 28
• Journal article
  Piper PJ, Tippins JR, Morris HR, Taylor GWet al., 1980,

  Potentiation of SRS-A release from guinea pig chopped lung by substrates for arachidonate lipoxygenase.

  , Adv Prostaglandin Thromboxane Res, Vol: 6, Pages: 121-124, ISSN: 0361-5952
  • Author Web Link
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• Journal article
  GEFFEN A, 1979,

  ROTATING FISH CAGES TO PREVENT FOULING

  , AQUACULTURE, Vol: 16, Pages: 83-85, ISSN: 0044-8486
  • Cite
  • Citations: 2
• Journal article
  SHAW WV, PACKMAN LC, BURLEIGH BD, DELL A, MORRIS HR, HARTLEY BSet al., 1979,

  PRIMARY STRUCTURE OF A CHLORAMPHENICOL ACETYLTRANSFERASE SPECIFIED BY R-PLASMIDS

  , NATURE, Vol: 282, Pages: 870-872, ISSN: 0028-0836
  • Author Web Link
  • Cite
  • Citations: 125
• Journal article
  RUTHERFORD AW, EVANS MCW, 1979,

  HIGH-POTENTIAL SEMIQUINONE-IRON SIGNAL IN RHODOPSEUDOMONAS-VIRIDIS IS THE SPECIFIC QUINONE SECONDARY-ELECTRON ACCEPTOR IN THE PHOTOSYNTHETIC REACTION CENTER

  , FEBS LETTERS, Vol: 104, Pages: 227-230, ISSN: 0014-5793
  • Author Web Link
  • Cite
  • Citations: 29
• Journal article
  RUTHERFORD AW, EVANS MCW, 1979,

  HIGH-POTENTIAL SEMIQUINONE-IRON TYPE EPR SIGNAL IN RHODOPSEUDOMONAS-VIRIDIS

  , FEBS LETTERS, Vol: 100, Pages: 305-308, ISSN: 0014-5793
  • Author Web Link
  • Cite
  • Citations: 18
• Journal article
  MORRIS HR, PIPER PJ, TAYLOR GW, TIPPINS JRet al., 1979,

  EFFECT OF ARACHIDONATE LIPOXYGENASE SUBSTRATES AND INHIBITORS ON SRS-A RELEASE IN THE GUINEA-PIG LUNG

  , BRITISH JOURNAL OF PHARMACOLOGY, Vol: 66, Pages: P452-P452, ISSN: 0007-1188
  • Author Web Link
  • Cite
  • Citations: 21
• Journal article
  Piper PJ, Tippins JR, Morris HR, Taylor GWet al., 1979,

  Arachidonic acid metabolism and SRS-A.

  , Agents Actions Suppl, Pages: 37-48, ISSN: 0379-0363
  • Author Web Link
  • Cite
• Journal article
  FRANKS NP, LIEB WR, 1979,

  STRUCTURE OF LIPID BILAYERS AND THE EFFECTS OF GENERAL-ANESTHETICS - X-RAY AND NEUTRON-DIFFRACTION STUDY

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 133, Pages: 469-500, ISSN: 0022-2836
  • Author Web Link
  • Cite
  • Citations: 235
• Journal article
  COHEN FE, STERNBERG MJE, TAYLOR W, 1979,

  ANALYSIS AND PREDICTION OF THE STACKING OF BETA-PLEATED SHEETS

  , HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, Vol: 360, Pages: 1003-1004, ISSN: 0018-4888
  • Author Web Link
  • Cite
• Journal article
  STERNBERG MJE, GRACE DEP, PHILLIPS DC, 1979,

  DYNAMIC INFORMATION FROM PROTEIN CRYSTALLOGRAPHY - ANALYSIS OF TEMPERATURE FACTORS FROM REFINEMENT OF THE HEN EGG-WHITE LYSOZYME STRUCTURE

  , JOURNAL OF MOLECULAR BIOLOGY, Vol: 130, Pages: 231-252, ISSN: 0022-2836
  • Author Web Link
  • Cite
  • Citations: 144
• Journal article
  RICHARDS FM, RICHMOND TJ, STERNBERG MJE, COHEN FEet al., 1979,

  FORMATION AND FLUCTUATIONS OF TERTIARY STRUCTURE - ASSOCIATION OF ALPHA-HELICES

  , HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, Vol: 360, Pages: 1013-1014, ISSN: 0018-4888
  • Author Web Link
  • Cite
• Journal article
  BATTERSBY AR, MATCHAM WJ, MCDONALD E, NEIER R, THOMPSON M, WOGGON WD, BYKOVSKY VY, MORRIS HRet al., 1979,

  BIOSYNTHESIS OF VITAMIN-B12 - STRUCTURE OF THE TRIMETHYLISOBACTERIOCHLORIN FROM PROPIONIBACTERIUM-SHERMANII

  , JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, Pages: 185-186, ISSN: 0022-4936
  • Author Web Link
  • Cite
  • Citations: 39
• Journal article
  ARTYMIUK PJ, BLAKE CCF, GRACE DEP, OATLEY SJ, PHILLIPS DC, STERNBERG MJEet al., 1979,

  CRYSTALLOGRAPHIC STUDIES OF THE DYNAMIC PROPERTIES OF LYSOZYME

  , NATURE, Vol: 280, Pages: 563-568, ISSN: 0028-0836
  • Author Web Link
  • Cite
  • Citations: 412
• Journal article
  DELL A, JOHNSON BL, 1979,

  ACETOLYSIS OF ENDO-5-METHYLTRICYCLO-[2,2,1,02,6]HEPT-EXO-3-YL AND ENDO-5-METHYLTRICYCLO[2,2,1,02,6]HEPT-ENDO-3-YL PARA-BROMOBENZENESULFONATES

  , AUSTRALIAN JOURNAL OF CHEMISTRY, Vol: 32, Pages: 2215-2221, ISSN: 0004-9425
  • Author Web Link
  • Cite
• Journal article
  Morris HR, Taylor GW, Piper PJ, Tippins JRet al., 1979,

  Slow-reacting substance of anaphylaxis: studies on purification and characterisation.

  , Agents Actions Suppl, Pages: 27-36, ISSN: 0379-0363

  We have demonstrated the role of arachidonic acid and lipoxygenase in the genesis of SRS-A and the possible role of lipoxygenases in its metabolism. SRS-A has been purified in microgram quantities together with closely related material. We have identified 5,12 di-hydroxy-6, 8, 10, 14 eicosatetranenoic acid released by antigen challenge, and which we feel is related to SRS-A. Further structural work is in progress.

  • Abstract
  • Author Web Link
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• Journal article
  MORRIS HR, 1979,

  RESEARCH ON PEPTIDES AND GLYCOPEPTIDES

  , PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 293, Pages: 39-51, ISSN: 1364-503X
  • Author Web Link
  • Cite
  • Citations: 22
• Journal article
  MORRIS HR, PIPER PJ, TAYLOR GW, TIPPINS JRet al., 1979,

  COMPARATIVE STUDIES ON IMMUNOLOGICALLY AND NON-IMMUNOLOGICALLY PRODUCED SLOW-REACTING SUBSTANCES FROM MAN, GUINEA-PIG AND RAT

  , BRITISH JOURNAL OF PHARMACOLOGY, Vol: 67, Pages: 179-184, ISSN: 0007-1188
  • Author Web Link
  • Cite
  • Citations: 36
• Journal article
  RUTHERFORD AW, HEATHCOTE P, EVANS MCW, 1979,

  ELECTRON-PARAMAGNETIC-RESONANCE MEASUREMENTS OF THE ELECTRON-TRANSFER COMPONENTS OF THE REACTION CENTER OF RHODOPSEUDOMONAS-VIRIDIS - OXIDATION-REDUCTION POTENTIALS AND INTERACTIONS OF THE ELECTRON-ACCEPTORS

  , BIOCHEMICAL JOURNAL, Vol: 182, Pages: 515-523, ISSN: 0264-6021
  • Author Web Link
  • Cite
  • Citations: 42
• Journal article
  TOBIAS JA, 1978,

  PACING AT A VERY SHORT PULSE WIDTH

  , ANNALS OF THORACIC SURGERY, Vol: 26, Pages: 27-31, ISSN: 0003-4975
  • Cite

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