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  • Journal article
    Morris HR, Williams DH, Ambler RP, 1971,

    Determination of the sequences of protein-derived peptides and peptide mixtures by mass spectrometry.

    , Biochem J, Vol: 125, Pages: 189-201, ISSN: 0264-6021

    Micro-quantities of protein-derived peptides have been converted into N-acetylated permethyl derivatives, and their sequences determined by low-resolution mass spectrometry without prior knowledge of their amino acid compositions or lengths. A new strategy is suggested for the mass spectrometric sequencing of oligopeptides or proteins, involving gel filtration of protein hydrolysates and subsequent sequence analysis of peptide mixtures. Finally, results are given that demonstrate for the first time the use of mass spectrometry for the analysis of a protein-derived peptide mixture, again without prior knowledge of the protein or components within the mixture.
  • Journal article
    Lawson DE, Fraser DR, Kodicek E, Morris HR, Williams DHet al., 1971,

    Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism.

    , Nature, Vol: 230, Pages: 228-230, ISSN: 0028-0836
  • Journal article
    TOBIAS JAY, MERLIS S, 1970,

    LEVODOPA AND SCHIZOPHRENIA

    , JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 211, Pages: 1857-&
  • Journal article
    Lucas F, Barber M, Wolstenholme WA, Geddes AJ, Graham GN, Morris HRet al., 1969,

    Mass-spectrometric determination of the amino acid sequences in peptides isolated from the protein silk fibroin of Bombyx mori.

    , Biochem J, Vol: 114, Pages: 695-702, ISSN: 0264-6021

    Several peptides were isolated from the protein silk fibroin of Bombyx mori by means of ion-exchange chromatography of a chymotryptic digest. The sequences of three of the peptides, Gly-Ala-Gly-Tyr, Gly-Val-Gly-Tyr and Gly-Ala-Gly-Ala-Gly-Ala-Gly-Tyr, were known from previous chemical work, but the sequence of the fourth, Gly-Ala-Gly-Val-Gly-Ala-Gly-Tyr, was previously only partially known. The necessary volatility for mass-spectrometric examination of the peptides was achieved by permethylation of the N-acetyl-peptide methyl ester derivatives. From the mass spectra it was possible to confirm the known sequences and to establish that of the partially known one. In one instance it was possible to deduce from the same mass spectrum the sequence of a main peptide component and that of a small amount of contaminating peptide. These results demonstrate for the first time the use of mass spectrometry in the determination of the amino acid sequences in peptides from a protein hydrolysate.
  • Journal article
    Morris HR, Geddes AJ, Graham GN, 1969,

    Some problems associated with the amino acid-sequence analysis of proteins by mass spectrometry.

    , Biochem J, Vol: 111, ISSN: 0264-6021
  • Journal article
    Cohen F, Sternberg M, 1965,

    [Trials with oxyphenbutazone in pediatrics].

    , Ann Pediatr (Paris), Vol: 12, Pages: 391-395, ISSN: 0066-2097
  • Journal article
    HD Williams, RK Poole,

    Reduction of ferric iron by Escherichia coli

    , Society for General Microbiology Quarterly, Vol: 10, Pages: 4-4
  • Thesis dissertation
    Chen S-Y,

    On subannual variability in the abyssal ocean

    <jats:p>The abyssal ocean is a critical yet understudied component of the climate system and is of growing economic interest. This thesis combines field observations and numerical modeling to advance our understanding of subannual variability in the abyssal ocean and its broader implications. First, hydrographic measurements from the Clarion-Clipperton Zone of the tropical eastern North Pacific are used to characterize the structure and variability of the bottom mixed layer (BML) in a region targeted for deep-sea mining. The observations reveal a spatially and temporally variable BML with a mean thickness of ∼250m and influenced by interactions with mesoscale eddies and abyssal thermal fronts. A simplified model of sediment transport suggests that such variations in BML structure could significantly influence the dispersal of sediments resuspended by seabed mining activities. Second, idealized model experiments are conducted to explore the genesis of benthic storms – episodes of strong near-bottom flows and sediment entrainment – underneath an unstable, surface-intensified jet resembling the Gulf Stream east of Cape Hatteras. In these experiments, the baroclinic instability of the jet gives rise to deep cyclonic and anticyclonic eddies through eddy barotropization and produces high levels of eddy kinetic energy at abyssal depths through the convergence of vertical eddy pressure fluxes. The near-bottom currents are comparable in magnitude to those observed during benthic storms, with vertical shears strong enough to produce BMLs up to 𝒪(100)m thick. Deep cyclonic eddies transport particles from near the bottom over the entire BML and could contribute to benthic nepheloid layers. The results suggest that the abyssal response to the intrinsic instability of surface-intensified currents could contribute significantly to subannual variability near the seafloor. Third, a model simulation of western North Atlantic circulation is performed to study th
  • Journal article
    Xiao Y, Wigneshweraraj SR, Weinzierl R, Wang YP, Buck Met al.,

    Construction and functional analyses of a comprehensive sigma54 site-directed mutant library using alanine-cysteine mutagenesis.

    , Nucleic Acids Res., Vol: 37, Pages: 4482-4497
  • Journal article
    Cámara B, Liu M, Reynolds J, Shadrin A, Liu B, Kwok K, Simpson P, Weinzierl R, Severinov K, Cota E, Matthews S, Wigneshweraraj SRet al.,

    T7 phage protein Gp2 inhibits the Escherichia coli RNA polymerase by antagonizing stable DNA strand separation near the transcription start site.

    , Proc Natl Acad Sci USA, Vol: 107, Pages: 2247-2252
  • Journal article
    Weinzierl RO, Axton JM, Ghysen A, Akam Met al.,

    Ultrabithorax mutations in constant and variable regions of the protein coding sequence.

    , Genes & Dev., Vol: 1, Pages: 386-397
  • Patent
    Collins J, Mann D, Armstrong A, Low Cet al.,

    CDC25 inhibitors

    , GB 1005980.6
  • Conference paper
    Ho KK, Mann DJ,

    The Role of Nuclear PtdIns(4,5)P2 turnover in Mammalian Cell Cycle

    , Gordon Research Conference on Signal Transduction Within the Nucleus
  • Conference paper
    Child ES, Mann DJ,

    Role of the cyclin encoded by human Herpesvirus 8 in the deregulation of the cell cycle

    , UK Molecular Biology and Cancer Network meeting
  • Conference paper
    Mann DJ, Jones NC,

    E2F-1 but not E2F-4 can overcome p16-induced cell cycle arrest.

    , Cold Spring Harbor meeting on The Cell Cycle
  • Conference paper
    Mann DJ, Jones NC,

    Use of cdk-specific inhibitors to analyse the G1/S transition in mammalian cells

    , DNA Tumour Viruses
  • Conference paper
    Mann DJ, Cohen PTW,

    Protein serine/threonine phosphatase V, the D. melanogaster homologue of S. cerevisiae SIT4

    , FASEB meeting on Protein Phosphatases
  • Conference paper
    Mann DJ, Cohen PTW,

    Identification of a novel Drosophila protein phosphatase, PPV

    , EMBO-FEBS meeting on Protein Phosphatases
  • Patent
    Weinzierl RO,

    Chromatin Topology

    , 0116453.2
  • Software
    Gilestro GF, Cirelli C,

    pySolo

    pySolo is a multiplatform software for analysis of sleep and locomotor activity in Drosophila melanogaster. pySolo provides a user-friendly graphic interface and it has been developed with the specific aim of being accessible, portable, fast and easily expandable through an intuitive plug-in structure. Support for development of additional plug-ins is provided through a community website. AVAILABILITY: Software and documentation are located at (http://www.pysolo.net). pySolo is a free software released under the GNU General Public License.
  • Journal article
    TR BMAH,

    Buck and Hoover, An ATPase R-Finger Leaves Its Print on Transcriptional Activation, Structure (2010), doi:10.1016/j.str.2010.10.002
  • Journal article
    Stumpf MHTTXSTTGJCEMBJWPMPH,

    M. Huvet, T. Toni, X. Sheng, T. Thorne, G. Jovanovic, C. Engl, M. Buck, J.W. Pinney, M.P.H. Stumpf. Mapping the evolution of the Phage shock protein (Psp) response system: interplay between protein function, genomic organization and system function, Molecular Biology Evolution (In Press)

    , Molecular Biology Evolution (In Press)
  • Journal article
    Aukauloo A, Leibl W, Rutherford AW,

    Water photolysis by molecular biomimetics

    , ACTUALITE CHIMIQUE, Pages: 42-49, ISSN: 0151-9093
  • Journal article
    Pitelka LF, Gardner RH, Ash J, Berry S, Gitay H, Noble IR, Saunders A, Bradshaw RHW, Brubaker L, Clark JS, Davis MB, Sugita S, Dyer JM, Hengeveld R, Hope G, Huntley B, King GA, Lavorel S, Mack RN, Malanson GP, McGlone M, Prentice IC, Rejmanek Met al.,

    Plant migration and climate change (vol 85, pg 464, 1997)

    , AMERICAN SCIENTIST, Vol: 85, Pages: 501-501, ISSN: 0003-0996
  • Journal article
    Pitelka LF, Gardner RH, Ash J, Berry S, Gitay H, Noble IR, Saunders A, Bradshaw RHW, Brubaker L, Clark JS, Davis MB, Sugita S, Dyer JM, Hengeveld R, Hope G, Huntley B, King GA, Lavorel S, Mack RN, Malanson GP, McGlone M, Prentice IC, Rejmanek Met al.,

    Plant migration and climate change

    , AMERICAN SCIENTIST, Vol: 85, Pages: 464-473, ISSN: 0003-0996
  • Book chapter
    Song J, mermaz B, Liu F,

    RNA ImmunoPrecipitation protocol to identify protein-RNA interaction in Arabidopsis thaliana
  • Journal article
    Maitner BS, Pearse W, Roehrdanz P, Enquist BJ, Sanderson MJet al.,

    APPENDIX C. Re-scaling phylogenetic branches to reflect trait evolution

    , THE UNIVERSITY OF ARIZONA GRADUATE COLLEGE, Vol: 1001, Pages: 86-86
  • Book
    Panossian B,

    Genome profiling of vancomycin-resistant enterococcal clinical Isolates from Lebanon
  • Journal article
    DAVIS KR, DARVILL AG, ALBERSHEIM P, DELL Aet al.,

    HOST-PATHOGEN INTERACTIONS .30. CHARACTERIZATION OF ELICITORS OF PHYTOALEXIN ACCUMULATION IN SOYBEAN RELEASED FROM SOYBEAN CELL-WALLS BY ENDOPOLYGALACTURONIC ACID LYASE

    , ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, Vol: 41, Pages: 39-48, ISSN: 0939-5075
    • Cite
    • Citations: 44

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