@article{Lee:2022:10.1242/dev.200295,
author = {Lee, HC and Hastings, C and Oliveira, NMM and Perez-Carrasco, R and Page, KM and Wolpert, L and Stern, CD},
doi = {10.1242/dev.200295},
journal = {Development},
title = {'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours},
url = {http://dx.doi.org/10.1242/dev.200295},
volume = {149},
year = {2022}
}

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TY  - JOUR
AB  - In many developing and regenerating systems, tissue pattern is established through gradients of informative morphogens, but we know little about how cells interpret these. Using experimental manipulation of early chick embryos, including misexpression of an inducer (VG1 or ACTIVIN) and an inhibitor (BMP4), we test two alternative models for their ability to explain how the site of primitive streak formation is positioned relative to the rest of the embryo. In one model, cells read morphogen concentrations cell-autonomously. In the other, cells sense changes in morphogen status relative to their neighbourhood. We find that only the latter model can account for the experimental results, including some counter-intuitive predictions. This mechanism (which we name the 'neighbourhood watch' model) illuminates the classic 'French Flag Problem' and how positional information is interpreted by a sheet of cells in a large developing system.
AU  - Lee,HC
AU  - Hastings,C
AU  - Oliveira,NMM
AU  - Perez-Carrasco,R
AU  - Page,KM
AU  - Wolpert,L
AU  - Stern,CD
DO  - 10.1242/dev.200295
PY  - 2022///
SN  - 0950-1991
TI  - 'Neighbourhood watch' model: embryonic epiblast cells assess positional information in relation to their neighbours
T2  - Development
UR  - http://dx.doi.org/10.1242/dev.200295
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35438131
UR  - http://hdl.handle.net/10044/1/97051
VL  - 149
ER  - 

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