Citation

BibTex format

@article{Malladi:2022:10.1016/j.jmb.2022.167608,
author = {Malladi, S and Powell, HR and David, A and Islam, SA and Copeland, MM and Kundrotas, PJ and Sternberg, MJE and Vakser, I},
doi = {10.1016/j.jmb.2022.167608},
journal = {Journal of Molecular Biology},
title = {GWYRE: A resource for mapping variants onto experimental and modeled structures of human protein complexes},
url = {http://dx.doi.org/10.1016/j.jmb.2022.167608},
volume = {434},
year = {2022}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Rapid progress in structural modeling of proteins and their interactions is powered by advances in knowledge-based methodologies along with better understanding of physical principles of protein structure and function. The pool of structural data for modeling of proteins and protein–protein complexes is constantly increasing due to the rapid growth of protein interaction databases and Protein Data Bank. The GWYRE (Genome Wide PhYRE) project capitalizes on these developments by advancing and applying new powerful modeling methodologies to structural modeling of protein–protein interactions and genetic variation. The methods integrate knowledge-based tertiary structure prediction using Phyre2 and quaternary structure prediction using template-based docking by a full-structure alignment protocol to generate models for binary complexes. The predictions are incorporated in a comprehensive public resource for structural characterization of the human interactome and the location of human genetic variants. The GWYRE resource facilitates better understanding of principles of protein interaction and structure/function relationships. The resource is available at http://www.gwyre.org.
AU - Malladi,S
AU - Powell,HR
AU - David,A
AU - Islam,SA
AU - Copeland,MM
AU - Kundrotas,PJ
AU - Sternberg,MJE
AU - Vakser,I
DO - 10.1016/j.jmb.2022.167608
PY - 2022///
SN - 0022-2836
TI - GWYRE: A resource for mapping variants onto experimental and modeled structures of human protein complexes
T2 - Journal of Molecular Biology
UR - http://dx.doi.org/10.1016/j.jmb.2022.167608
UR - https://www.sciencedirect.com/science/article/pii/S0022283622001887
UR - http://hdl.handle.net/10044/1/96944
VL - 434
ER -