Citation

BibTex format

@article{Musasia:2022:10.1038/s41467-022-31640-6,
author = {Musasia, FK and Nkumama, IN and Frank, R and Kipkemboi, V and Schneider, M and Mwai, K and Odera, DO and Rosenkranz, M and Fürle, K and Kimani, D and Tuju, J and Njuguna, P and Hamaluba, M and Kapulu, MC and Wardemann, H and CHMI-SIKA, Study Team and Osier, FHA},
doi = {10.1038/s41467-022-31640-6},
journal = {Nat Commun},
title = {Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria.},
url = {http://dx.doi.org/10.1038/s41467-022-31640-6},
volume = {13},
year = {2022}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Ring-infected erythrocytes are the predominant asexual stage in the peripheral circulation but are rarely investigated in the context of acquired immunity against Plasmodium falciparum malaria. Here we compare antibody-dependent phagocytosis of ring-infected parasite cultures in samples from a controlled human malaria infection (CHMI) study (NCT02739763). Protected volunteers did not develop clinical symptoms, maintained parasitaemia below a predefined threshold of 500 parasites/μl and were not treated until the end of the study. Antibody-dependent phagocytosis of both ring-infected and uninfected erythrocytes from parasite cultures was strongly correlated with protection. A surface proteomic analysis revealed the presence of merozoite proteins including erythrocyte binding antigen-175 and -140 on ring-infected and uninfected erythrocytes, providing an additional antibody-mediated protective mechanism for their activity beyond invasion-inhibition. Competition phagocytosis assays support the hypothesis that merozoite antigens are the key mediators of this functional activity. Targeting ring-stage parasites may contribute to the control of parasitaemia and prevention of clinical malaria.
AU - Musasia,FK
AU - Nkumama,IN
AU - Frank,R
AU - Kipkemboi,V
AU - Schneider,M
AU - Mwai,K
AU - Odera,DO
AU - Rosenkranz,M
AU - Fürle,K
AU - Kimani,D
AU - Tuju,J
AU - Njuguna,P
AU - Hamaluba,M
AU - Kapulu,MC
AU - Wardemann,H
AU - CHMI-SIKA,Study Team
AU - Osier,FHA
DO - 10.1038/s41467-022-31640-6
PY - 2022///
TI - Phagocytosis of Plasmodium falciparum ring-stage parasites predicts protection against malaria.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/s41467-022-31640-6
UR - https://www.ncbi.nlm.nih.gov/pubmed/35835738
VL - 13
ER -