@article{Prokopidis:2022:10.1002/jcsm.12976,
author = {Prokopidis, K and Giannos, P and Katsikas, Triantafyllidis K and Kechagias, KS and Mesinovic, J and Witard, OC and Scott, D},
doi = {10.1002/jcsm.12976},
journal = {Journal of Cachexia, Sarcopenia and Muscle},
pages = {1642--1652},
title = {Effect of vitamin D monotherapy on indices of sarcopenia in communitydwelling older adults: a systematic review and metaanalysis},
url = {http://dx.doi.org/10.1002/jcsm.12976},
volume = {13},
year = {2022}
}

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TY  - JOUR
AB  - BackgroundVitamin D supplementation is proposed as a potentially effective nutritional intervention to mitigate the risk of sarcopenia. The aim of this systematic review and meta-analysis was to investigate the impact of vitamin D supplementation monotherapy on indices of sarcopenia in community-dwelling older adults.MethodsA comprehensive search of the literature was conducted in PubMed, Web of Science, Scopus, and Cochrane Library. Eligible randomized controlled trials (RCTs) compared the effect of vitamin D supplementation (as monotherapy) with placebo on indices of sarcopenia in older (>50 years) adults. Using the random effects inverse-variance model, we calculated the mean difference (MD) in handgrip strength (HGS), short physical performance battery (SPPB), timed up and go (TUG), and appendicular lean mass (ALM) between groups. We also calculated the standardized mean difference (SMD) in general muscle strength and general physical performance (composite plot of all muscle strength and physical performance outcomes, respectively) between groups.ResultsTen RCTs were included in the meta-analysis. A significant decrease in SPPB scores was observed with vitamin D supplementation compared with placebo (MD: −0.23; 95% CI −0.40 to −0.06; I2 = 0%; P = 0.007). Vitamin D supplementation conferred no effect on HGS (MD: −0.07 kg; 95% CI −0.70 to 0.55; I2 = 51%, P = 0.82), TUG (MD: 0.07 s; 95% CI −0.08 to 0.22; I2 = 0%, P = 0.35), ALM (MD: 0.06 kg/m2; 95% CI: −0.32 to 0.44; I2 = 73%, P = 0.77), general muscle strength (SMD: −0.01; 95% CI −0.17 to 0.15; I2 = 42%, P = 0.90), or general physical performance (SMD: −0.02; 95% CI −0.23 to 0.18; I2 = 71%, P = 0.83).ConclusionsVitamin D supplementation did not improve any sarcopenia indices in community-dwelling older adults and may compromise some aspects of physical performance. Future studies are warranted to investigate the impact of vitamin D supplementati
AU  - Prokopidis,K
AU  - Giannos,P
AU  - Katsikas,Triantafyllidis K
AU  - Kechagias,KS
AU  - Mesinovic,J
AU  - Witard,OC
AU  - Scott,D
DO  - 10.1002/jcsm.12976
EP  - 1652
PY  - 2022///
SN  - 2190-5991
SP  - 1642
TI  - Effect of vitamin D monotherapy on indices of sarcopenia in communitydwelling older adults: a systematic review and metaanalysis
T2  - Journal of Cachexia, Sarcopenia and Muscle
UR  - http://dx.doi.org/10.1002/jcsm.12976
UR  - https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12976
UR  - http://hdl.handle.net/10044/1/98844
VL  - 13
ER  - 

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