Citation

BibTex format

@article{Meisl:2022:10.1126/sciadv.abn6831,
author = {Meisl, G and Xu, CK and Taylor, JD and Michaels, TCT and Levin, A and Otzen, D and Klenerman, D and Matthews, S and Linse, S and Andreasen, M and Knowles, TPJ},
doi = {10.1126/sciadv.abn6831},
journal = {Science Advances},
pages = {1--11},
title = {Uncovering the universality of self-replication in protein aggregation and its link to disease},
url = {http://dx.doi.org/10.1126/sciadv.abn6831},
volume = {8},
year = {2022}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Fibrillar protein aggregates are a hallmark of a range of human disorders, from prion diseases to dementias, but are also encountered in several functional contexts. Yet, the fundamental links between protein assembly mechanisms and their functional or pathological roles have remained elusive. Here, we analyze the aggregation kinetics of a large set of proteins that self-assemble by a nucleated-growth mechanism, from those associated with disease, over those whose aggregates fulfill functional roles in biology, to those that aggregate only under artificial conditions. We find that, essentially, all such systems, regardless of their biological role, are capable of self-replication. However, for aggregates that have evolved to fulfill a structural role, the rate of self-replication is too low to be significant on the biologically relevant time scale. By contrast, all disease-related proteins are able to self-replicate quickly compared to the time scale of the associated disease. Our findings establish the ubiquity of self-replication and point to its potential importance across aggregation-related disorders.
AU - Meisl,G
AU - Xu,CK
AU - Taylor,JD
AU - Michaels,TCT
AU - Levin,A
AU - Otzen,D
AU - Klenerman,D
AU - Matthews,S
AU - Linse,S
AU - Andreasen,M
AU - Knowles,TPJ
DO - 10.1126/sciadv.abn6831
EP - 11
PY - 2022///
SN - 2375-2548
SP - 1
TI - Uncovering the universality of self-replication in protein aggregation and its link to disease
T2 - Science Advances
UR - http://dx.doi.org/10.1126/sciadv.abn6831
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000841491100014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://www.science.org/doi/10.1126/sciadv.abn6831
UR - http://hdl.handle.net/10044/1/104152
VL - 8
ER -