@article{Mohammed:2022:10.1016/bs.acr.2022.06.001,
author = {Mohammed, NBB and Antonopoulos, A and Dell, A and Haslam, SM and Dimitroff, CJ},
doi = {10.1016/bs.acr.2022.06.001},
journal = {Advances in Cancer Research},
title = {The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma},
url = {http://dx.doi.org/10.1016/bs.acr.2022.06.001},
year = {2022}
}

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TY  - JOUR
AB  - Melanoma is a highly aggressive skin cancer with poor outcomes associated with distant metastasis. Intrinsic properties of melanoma cells alongside the crosstalk between melanoma cells and surrounding microenvironment determine the tumor behavior. Galectin-3 (Gal-3), a ß-galactoside-binding lectin, has emerged as a major effector in cancer progression, including melanoma behavior. Data from melanoma models and patient studies reveal that Gal-3 expression is dysregulated, both intracellularly and extracellularly, throughout the stages of melanoma progression. This review summarizes the most recent data and hypotheses on Gal-3 and its tumor-modulating functions, highlighting its role in driving melanoma growth, invasion, and metastatic colonization. It also provides insight into potential Gal-3-targeted strategies for melanoma diagnosis and treatment.
AU  - Mohammed,NBB
AU  - Antonopoulos,A
AU  - Dell,A
AU  - Haslam,SM
AU  - Dimitroff,CJ
DO  - 10.1016/bs.acr.2022.06.001
PY  - 2022///
SN  - 0065-230X
TI  - The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma
T2  - Advances in Cancer Research
UR  - http://dx.doi.org/10.1016/bs.acr.2022.06.001
UR  - https://www.sciencedirect.com/science/article/pii/S0065230X22000525?via%3Dihub
ER  - 

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