Citation

BibTex format

@article{Wu:2022:10.1038/s41598-022-20608-7,
author = {Wu, G and Grassi, P and MacIntyre, D and Molina, BG and Sykes, L and Kundu, S and Hsiao, C-T and Khoo, K-H and Bennett, P and Dell, A and Haslam, S},
doi = {10.1038/s41598-022-20608-7},
journal = {Scientific Reports},
pages = {1--14},
title = {N-Glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status},
url = {http://dx.doi.org/10.1038/s41598-022-20608-7},
volume = {12},
year = {2022}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Human cervicovaginal fluid (CVF) is a complex, functionally important and glycan rich biological fluid, fundamental in mediating physiological events associated with reproductive health. Using a comprehensive glycomic strategy we reveal an extremely rich and complex N-glycome in CVF of pregnant and non-pregnant women, abundant in paucimannose and highmannose glycans, complex glycans with 2-4 N-Acetyllactosamine (LacNAc) antennae, and Poly-LacNAc glycans decorated with fucosylation and sialylation. N-glycosylation variations were observed to differ in relation to pregnancy status, microbial composition, immune activation, and pregnancy outcome. Compared to CVF from women experiencing term birth, CVF from women who subsequently experienced preterm birth showed lower sialylation, which correlated to the presence of a diverse microbiome, and higher fucosylation, which correlated positively to pro-inflammatory cytokine concentration. This study is the first step towards better understanding the role of cervicovaginal glycans in reproductive health, their contribution to the mechanism of microbial driven preterm birth, and their potential forpreventative therapy.
AU - Wu,G
AU - Grassi,P
AU - MacIntyre,D
AU - Molina,BG
AU - Sykes,L
AU - Kundu,S
AU - Hsiao,C-T
AU - Khoo,K-H
AU - Bennett,P
AU - Dell,A
AU - Haslam,S
DO - 10.1038/s41598-022-20608-7
EP - 14
PY - 2022///
SN - 2045-2322
SP - 1
TI - N-Glycosylation of cervicovaginal fluid reflects microbial community, immune activity, and pregnancy status
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-022-20608-7
UR - https://www.nature.com/articles/s41598-022-20608-7
UR - http://hdl.handle.net/10044/1/99782
VL - 12
ER -