In this section
@article{Ferrando-Marco:2025:10.1242/dev.204546,
author = {Ferrando-Marco, M and Barkoulas, M},
doi = {10.1242/dev.204546},
journal = {Development},
title = {EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.},
url = {http://dx.doi.org/10.1242/dev.204546},
volume = {152},
year = {2025}
}
TY - JOUR
AB - The E2F family of transcription factors is conserved in higher eukaryotes and plays pivotal roles in controlling gene expression during the cell cycle. Most canonical E2Fs associate with members of the Dimerisation Partner (DP) family to activate or repress target genes. However, atypical repressors, such as E2F7 and E2F8, lack DP interaction domains and their functions are less understood. We report here that EFL-3, the E2F7 homologue of Caenorhabditis elegans, regulates epidermal stem cell differentiation. We show that phenotypic defects in efl-3 mutants depend on the Nemo-like kinase LIT-1. EFL-3 represses lit-1 expression through direct binding to a lit-1 intronic element. Increased LIT-1 expression in efl-3 mutants reduces POP-1/TCF nuclear distribution, and consequently alters Wnt pathway activation. Our findings provide a mechanistic link between an atypical E2F family member and NLK during C. elegans asymmetric cell division, which may be conserved in other animals.
AU - Ferrando-Marco,M
AU - Barkoulas,M
DO - 10.1242/dev.204546
PY - 2025///
TI - EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.
T2 - Development
UR - http://dx.doi.org/10.1242/dev.204546
UR - https://www.ncbi.nlm.nih.gov/pubmed/40026193
VL - 152
ER -
Interested in studying a PhD at the Department of Life Sciences? Find out more about postgraduate research opportunties.