BibTex format
@article{Miles:2025:10.1038/s41467-025-64057-y,
author = {Miles, SL and Santillo, D and Painter, H and Wright, K and Torraca, V and López-Jiménez, AT and Virgo, M and Matanza, XM and Clements, A and Jenkins, C and Baker, S and Baker, KS and Cisneros, D and Puhar, A and Sancho-Shimizu, V and Holt, KE and Mostowy, S},
doi = {10.1038/s41467-025-64057-y},
journal = {Nat Commun},
title = {Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei.},
url = {http://dx.doi.org/10.1038/s41467-025-64057-y},
volume = {16},
year = {2025}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Shigellosis is a leading cause of diarrhoeal deaths, with Shigella sonnei increasingly implicated as a dominant agent. S. sonnei is divided into five monophyletic lineages, yet most infections are caused by a few clonal sub-lineages within Lineage 3 that are quite distinct from the widely used Lineage 2 laboratory strain 53G. Factors underlying the success of these globally dominant lineages remain unclear in part due to a lack of complete genome sequences and animal models. Here, we utilise a novel reference collection of representative Lineage 1, 2 and 3 isolates and find that epidemiologically successful S. sonnei harbour fewer genes encoding putative immunogenic components whilst key virulence-associated regions (including the type three secretion system and O-antigen) remain highly conserved. Using a zebrafish infection model, Lineage 3 isolates proved most virulent, driven by increased dissemination and a greater neutrophil response. These isolates also show increased resistance to complement-mediated killing alongside upregulated expression of group four capsule synthesis genes. Consistently, primary human neutrophil infections revealed an increased tolerance to phagosomal killing. Together, our findings link the epidemiological success of S. sonnei to heightened virulence and stress tolerance, and highlight zebrafish as a valuable platform to illuminate factors underlying establishment of epidemiological success.
AU - Miles,SL
AU - Santillo,D
AU - Painter,H
AU - Wright,K
AU - Torraca,V
AU - López-Jiménez,AT
AU - Virgo,M
AU - Matanza,XM
AU - Clements,A
AU - Jenkins,C
AU - Baker,S
AU - Baker,KS
AU - Cisneros,D
AU - Puhar,A
AU - Sancho-Shimizu,V
AU - Holt,KE
AU - Mostowy,S
DO - 10.1038/s41467-025-64057-y
PY - 2025///
TI - Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/s41467-025-64057-y
UR - https://www.ncbi.nlm.nih.gov/pubmed/41068110
VL - 16
ER -