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  • Journal article
    Gallo J, Alam IS, Jin J, Gu Y-J, Aboagye EO, Wong W-T, Long NJet al., 2014,

    PET imaging with multimodal upconversion nanoparticles

    , DALTON TRANSACTIONS, Vol: 43, Pages: 5535-5545, ISSN: 1477-9226
  • Journal article
    Gallo J, Alam IS, Lavdas I, Wylezinska-Arridge M, Aboagye EO, Long NJet al., 2013,

    RGD-targeted MnO nanoparticles as T1 contrast agents for cancer imaging – the effect of PEG length in vivo

    , J. Mater. Chem. B

    As magnetic resonance imaging (MRI) contrast agents, T1 Gd3+ chelates are generally the preferred option for radiologists over T2 iron oxide nanoparticles. The main reason for the popularity of T1 agents is the easier interpretation of T1-weighted MR images. However, the chemical versatility of nanoparticulate platforms makes them ideal candidates for the next generation of targeted MRI contrast agents. In this context, we present herein the design and preparation of a nanoparticulate contrast agent based on MnO, which presents T1 contrast enhancement properties as well as nanoparticle formulation. Functionalization of MnO nanoparticles with the extensively studied RGD peptide was used to target tumours over-expressing the αvβ3 integrin. PEG (polyethylene glycol) molecules were used to increase the blood half-life of the nanoparticles in vivo, and the effect of different PEG lengths on the final contrast on MR images was investigated.
  • Journal article
    Rivas C, Stasiuk GJ, Gallo J, Minuzzi F, Rutter GA, Long NJet al., 2013,

    Lanthanide(III) Complexes of Rhodamine-DO3A Conjugates as Agents for Dual-Modal Imaging

    , INORGANIC CHEMISTRY, Vol: 52, Pages: 14284-14293, ISSN: 0020-1669
    • Cite
    • Citations: 45
  • Journal article
    Bakewell C, White AJP, Long NJ, Williams CKet al., 2013,

    8-quinolinolato gallium complexes: iso-selective initiators for rac-lactide polymerization

    , Inorganic Chemistry, Vol: 52, Pages: 12561-12567, ISSN: 1520-510X

    The synthesis and characterization of a series of 8-quinolinolato gallium complexes is presented, and the complexes are analogous to a series of aluminum complexes previously reported. The complexes have been shown to be active initiators for the ring-opening polymerization of rac-lactide. High degrees of polymerization control are demonstrated, as exemplified by the linear evolution of molecular weight as the polymerization progresses, narrow polydispersity indices, and molecular weights corresponding to those predicted on the basis of initiator concentration. Some of the initiators show iso-selective polymerization of rac-lactide, with Pi = 0.70. The polymerization rates have been monitored, and the pseudo first-order rate constants are compared to those of analogous aluminum compounds. The 8-quinolinolato gallium initiators show rates approximately 3 times higher than those of the series of aluminum compounds, while maintaining equivalently high iso-selectivity (Pi = 0.70) and polymerization control.
  • Journal article
    Inkpen MS, Albrecht T, Long NJ, 2013,

    Branched Redox-Active Complexes for the Study of Novel Charge Transport Processes

    , ORGANOMETALLICS, Vol: 32, Pages: 6053-6060, ISSN: 0276-7333
  • Conference paper
    Stasiuk GJ, Minuzzi F, Sae-Heng M, Long NJ, Rutter GAet al., 2013,

    Dual modal MR/fluorescent zinc sensing probes for in vivo beta cell imaging

    , 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Publisher: SPRINGER, Pages: S211-S211, ISSN: 0012-186X
  • Journal article
    Haslop A, Gee A, Plisson C, Long Net al., 2013,

    Fully automated radiosynthesis of [1-(2-[18F]fluoroethyl),1H[1,2,3]triazole 4-ethylene] triphenylphosphonium bromide as a potential positron emission tomography tracer for imaging apoptosis

    , JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: 313-316, ISSN: 0362-4803
  • Journal article
    Haslop A, Wells L, Murphy P, Gee A, Long N, Plisson Cet al., 2013,

    Novel <SUP>18</SUP>F-labelled phosphonium cations as imaging agents of the mitochondrial membrane potential during apoptosis

    , JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, Vol: 56, Pages: S143-S143, ISSN: 0362-4803
  • Conference paper
    Bakewell CM, Thi-Phuong-Anh C, Haaf M, Williams CK, Long NJ, Auffrant A, Platel RHet al., 2013,

    <i>Bis</i>(quinolinolato)aluminium ethyl and yttrium phosphasalen complexes: New <i>iso</i>-selective initiators for <i>rac</i>-lactide ring-opening polymerisation

    , Symposium on Physicochemical Characterization of Organic Matter - Past, Present, Future, and Role of Environment / 245th National Spring Meeting of the American-Chemical-Society (ACS), Publisher: AMER CHEMICAL SOC, ISSN: 0065-7727
  • Journal article
    Bakewell C, Thi-Phuong-Anh C, Le Goff XF, Long NJ, Auffrant A, Williams CKet al., 2013,

    Yttrium Phosphasalen Initiators for <i>rac</i>-Lactide Polymerization

    , ORGANOMETALLICS, Vol: 32, Pages: 1475-1483, ISSN: 0276-7333
    • Cite
    • Citations: 59
  • Journal article
    Gallo J, Long NJ, Aboagye EO, 2013,

    Magnetic nanoparticles as contrast agents in the diagnosis and treatment of cancer

    , CHEMICAL SOCIETY REVIEWS, Vol: 42, Pages: 7816-7833, ISSN: 0306-0012
    • Cite
    • Citations: 202
  • Journal article
    Stasiuk GJ, Long NJ, 2013,

    The ubiquitous DOTA and its derivatives: the impact of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid on biomedical imaging

    , CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 2732-2746, ISSN: 1359-7345
  • Journal article
    Stasiuk GJ, Smith H, Wylezinska-Arridge M, Tremoleda JL, Trigg W, Luthra SK, Iveson VM, Gavins FNE, Long NJet al., 2013,

    Gd<SUP>3+</SUP> cFLFLFK conjugate for MRI: a targeted contrast agent for FPR1 in inflammation

    , CHEMICAL COMMUNICATIONS, Vol: 49, Pages: 564-566, ISSN: 1359-7345
    • Cite
    • Citations: 30
  • Journal article
    Inkpen MS, Du S, Driver M, Albrecht T, Long NJet al., 2013,

    Oxidative purification of halogenated ferrocenes

    , Dalton Transactions, Vol: 42, Pages: 2813-2816
  • Journal article
    Tietz O, Kamaly N, Smith G, Shamsaei E, Bhakoo KK, Long NJ, Aboagye EOet al., 2013,

    Design, synthesis and in vitro characterization of fluorescent and paramagnetic CXCR4-targeted imaging agents.

    , Am J Nucl Med Mol Imaging, Vol: 3, Pages: 372-383, ISSN: 2160-8407

    The G-protein coupled C-X-C chemokine receptor type 4 (CXCR4) is highly overexpressed in a range of cancers and is therefore an excellent biomarker for cancer imaging. To this end targeted iron oxide nanoparticles were developed and utilised for in vitro imaging of MDA-MB-231 breast cancer cells overexpressing the CXCR4 receptor. Nanoparticles comprising an iron oxide core, encapsulated in a stabilising epichlorohydrin crossed-linked dextran polymer, were conjugated to a cyclopentapeptide with affinity to the CXCR4 receptor. The particles were characterized for their size, surface charge and r2 relaxivity at 4.7 T. MR imaging of the CXCR4 receptor with targeted iron oxide nanoparticles revealed an approximately 3-fold increase in T2 signal enhancement of MDA-MB-231 cells compared to non-targeted controls. Prussian blue staining of labeled MDA-MB-231 cells revealed darker and more intense staining of the cellular membrane. This study demonstrates the potential of targeted iron oxide nanoparticles for the imaging of the CXCR4 receptor by magnetic resonance imaging (MRI).

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Professor Nick Long
Email: n.long@imperial.ac.uk
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