In this section
@article{Wu:2021:10.1002/anie.202108885,
author = {Wu, Y and Chau, H-F and Thor, W and Chan, KHY and Ma, X and Chan, W-L and Long, NJ and Wong, K-L},
doi = {10.1002/anie.202108885},
journal = {Angewandte Chemie International Edition},
pages = {20301--20307},
title = {Solid-phase peptide macrocyclization and multifunctionalization via dipyrrin construction},
url = {http://dx.doi.org/10.1002/anie.202108885},
volume = {60},
year = {2021}
}
TY - JOUR
AB - We introduce a new and highly efficient synthetic protocol towards multifunctional fluorescent cyclopeptides by solid-phase peptide macrocyclization via dipyrrin construction, with full scope of proteinogenic amino acids and different ring sizes. Various bicyclic peptides can be created by dipyrrin-based crosslinking and double dipyrrin-ring formation. The embedded dipyrrin can be either transformed to fluorescent BODIPY and then utilized as cancer-selective targeted protein imaging probe in vitro, or directly employed as a selective metal sensor in aqueous media. This work provides a valuable addition to the peptide macrocyclization toolbox, and a blueprint for the development of multifunctional dipyrrin linkers in cyclopeptides for a wide range of potential bioapplications.
AU - Wu,Y
AU - Chau,H-F
AU - Thor,W
AU - Chan,KHY
AU - Ma,X
AU - Chan,W-L
AU - Long,NJ
AU - Wong,K-L
DO - 10.1002/anie.202108885
EP - 20307
PY - 2021///
SN - 1433-7851
SP - 20301
TI - Solid-phase peptide macrocyclization and multifunctionalization via dipyrrin construction
T2 - Angewandte Chemie International Edition
UR - http://dx.doi.org/10.1002/anie.202108885
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000681757300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://onlinelibrary.wiley.com/doi/10.1002/anie.202108885
VL - 60
ER -
Professor Nick Long
Email: n.long@imperial.ac.uk
Telephone: +44 (0)20 7594 5781
501J
Molecular Sciences Research Hub
White City Campus
