BibTex format

author = {Wu, Y and Chau, H and Thor, W and Chan, KHY and Ma, X and Chan, W and Long, NJ and Wong, K},
doi = {10.1002/ange.202108885},
journal = {Angewandte Chemie},
pages = {20463--20469},
title = {SolidPhase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction},
url = {},
volume = {133},
year = {2021}

RIS format (EndNote, RefMan)

AB - <jats:title>Abstract</jats:title><jats:p>We introduce a new and highly efficient synthetic protocol towards multifunctional fluorescent cyclopeptides by solidphase peptide macrocyclization via dipyrrin construction, with full scope of proteinogenic amino acids and different ring sizes. Various bicyclic peptides can be created by dipyrrinbased crosslinking and double dipyrrinring formation. The embedded dipyrrin can be either transformed to fluorescent BODIPY and then utilized as cancerselective targeted protein imaging probe in vitro, or directly employed as a selective metal sensor in aqueous media. This work provides a valuable addition to the peptide macrocyclization toolbox, and a blueprint for the development of multifunctional dipyrrin linkers in cyclopeptides for a wide range of potential bioapplications.</jats:p>
AU - Wu,Y
AU - Chau,H
AU - Thor,W
AU - Chan,KHY
AU - Ma,X
AU - Chan,W
AU - Long,NJ
AU - Wong,K
DO - 10.1002/ange.202108885
EP - 20469
PY - 2021///
SN - 0044-8249
SP - 20463
TI - SolidPhase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction
T2 - Angewandte Chemie
UR -
VL - 133
ER -