BibTex format

author = {Sherrard-Smith, E and Winskill, P and Hamlet, A and Ngufor, C and N'Guessan, R and Guelbeogo, MW and Sanou, A and Nash, RK and Hill, A and Russell, EL and Woodbridge, M and Tungu, P and Kont, MD and McLean, T and Fornadel, C and Richardson, JH and Donnelly, MJ and Staedke, SG and Gonahasa, S and Protopopoff, N and Rowland, M and Churcher, TS},
doi = {10.1016/S2542-5196(21)00296-5},
journal = {The Lancet Planetary Health},
pages = {e100--e109},
title = {Optimising the deployment of vector control tools against malaria: a data-informed modelling study},
url = {},
volume = {6},
year = {2022}

RIS format (EndNote, RefMan)

AB - Background Concern that insecticide resistant mosquitoes are threatening malaria control has driven the development of new types of insecticide treated nets (ITNs) and indoor residual spraying (IRS). Malaria control programmes have a choice of vector control interventions though it is unclear which should be used to combat the disease.MethodsThe entomological impact of ITNs combining a pyrethroid insecticide with the synergist piperonyl butoxide (PBO) is characterised from experimental hut trials and used to parameterise a malaria transmission dynamics model. Model projections are validated for two sites by comparing results to data from pyrethroid-PBO ITN and IRS randomised control trials (RCTs). Models are used to identify optimum intervention packages for scenarios with varying budget, price, entomological and epidemiological factors. Findings Combining entomological data and models can reasonably predict changes in malaria in the Tanzanian and Ugandan RCTs. Models indicate switching from pyrethroid-only to pyrethroid-PBO ITNs could avert up to twice as many cases, though the additional benefit is highly variable and depends upon setting. Annual delivery of long-lasting, non-pyrethroid IRS is projected to prevent substantially more cases over 3-years, but pyrethroid-PBO ITNs tend to be the most cost-effective intervention per case averted. An online tool (MINT) provides users with a method of designing intervention packages given their setting and budget. InterpretationThe most cost-effective vector control package will vary locally. Models able to recreate results of RCTs can be used to extrapolate outcomes elsewhere to support evidence-based decision making for investment in vector control.FundingMedical Research Council, IVCC, Wellcome Trust.
AU - Sherrard-Smith,E
AU - Winskill,P
AU - Hamlet,A
AU - Ngufor,C
AU - N'Guessan,R
AU - Guelbeogo,MW
AU - Sanou,A
AU - Nash,RK
AU - Hill,A
AU - Russell,EL
AU - Woodbridge,M
AU - Tungu,P
AU - Kont,MD
AU - McLean,T
AU - Fornadel,C
AU - Richardson,JH
AU - Donnelly,MJ
AU - Staedke,SG
AU - Gonahasa,S
AU - Protopopoff,N
AU - Rowland,M
AU - Churcher,TS
DO - 10.1016/S2542-5196(21)00296-5
EP - 109
PY - 2022///
SN - 2542-5196
SP - 100
TI - Optimising the deployment of vector control tools against malaria: a data-informed modelling study
T2 - The Lancet Planetary Health
UR -
UR -
UR -
VL - 6
ER -